HUP0302407A2 - Új eljárás (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására és az eljárás intermedierjei - Google Patents

Új eljárás (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására és az eljárás intermedierjei

Info

Publication number
HUP0302407A2
HUP0302407A2 HU0302407A HUP0302407A HUP0302407A2 HU P0302407 A2 HUP0302407 A2 HU P0302407A2 HU 0302407 A HU0302407 A HU 0302407A HU P0302407 A HUP0302407 A HU P0302407A HU P0302407 A2 HUP0302407 A2 HU P0302407A2
Authority
HU
Hungary
Prior art keywords
tetrahydroisoquinoline
tert
carboxamide
butyl
intermediates
Prior art date
Application number
HU0302407A
Other languages
English (en)
Inventor
Pietro Bellani
Original Assignee
Clariant Life Science Molecules (Italia) S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant Life Science Molecules (Italia) S.P.A. filed Critical Clariant Life Science Molecules (Italia) S.P.A.
Publication of HUP0302407A2 publication Critical patent/HUP0302407A2/hu
Publication of HUP0302407A3 publication Critical patent/HUP0302407A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya új eljárás (S)-N-terc-butil-1,2,3,4 -tetrahidroizokinolin-3-karboxamid előállítására, melynek értelmében(a) (3S)-1,2,3,4-tetrahidroizokinolin-3-karbonsavat reagáltatnakhangyasavval, így (2) képletű vegyületet kapnak, (b) a kapottvegyületet terc-butil-aminnal reagáltatják, így (3) képletű vegyületetkapnak. (c) a kapott vegyületet savakkal kezelik, így (S)-N -terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamidot kapnak. A találmánytárgyát képezi továbbá egy eljárás vírusellenes aktivitássalrendelkező vegyületek előállítására, valamint a (2) és a (3) képletűköztitermék is. Ó
HU0302407A 2000-10-09 2001-09-27 New method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide and the intermediates HUP0302407A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002173A IT1318986B1 (it) 2000-10-09 2000-10-09 Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
PCT/IB2001/001788 WO2002030905A1 (en) 2000-10-09 2001-09-27 Method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Publications (2)

Publication Number Publication Date
HUP0302407A2 true HUP0302407A2 (hu) 2003-11-28
HUP0302407A3 HUP0302407A3 (en) 2009-01-28

Family

ID=11445926

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302407A HUP0302407A3 (en) 2000-10-09 2001-09-27 New method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide and the intermediates

Country Status (9)

Country Link
US (1) US6894167B2 (hu)
EP (1) EP1337514A1 (hu)
JP (1) JP2004511468A (hu)
KR (1) KR20030036899A (hu)
BR (1) BR0114157A (hu)
HU (1) HUP0302407A3 (hu)
IT (1) IT1318986B1 (hu)
MX (1) MXPA03003069A (hu)
WO (1) WO2002030905A1 (hu)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211960A (en) 1984-05-03 1989-05-29 Glaxo Group Ltd Benz(5,6)isoindolo(2,1-b)isoquinoline-8,13-dione derivatives and pharmaceutical compositions
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
US5256783A (en) 1991-09-18 1993-10-26 Hoffmann-La Roche Inc. Method for producing 2-isoquinoline compounds
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
ES2135171T5 (es) 1995-06-30 2006-03-16 Ajinomoto Co., Inc. Procedimiento para producir amidas opticamente activas.
US5587481A (en) * 1996-02-20 1996-12-24 The Monsanto Company Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide
IT1301825B1 (it) 1998-06-26 2000-07-07 Archimica Spa Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.

Also Published As

Publication number Publication date
MXPA03003069A (es) 2004-05-05
WO2002030905A1 (en) 2002-04-18
ITMI20002173A0 (it) 2000-10-09
IT1318986B1 (it) 2003-09-19
US6894167B2 (en) 2005-05-17
KR20030036899A (ko) 2003-05-09
HUP0302407A3 (en) 2009-01-28
US20040034056A1 (en) 2004-02-19
JP2004511468A (ja) 2004-04-15
EP1337514A1 (en) 2003-08-27
ITMI20002173A1 (it) 2002-04-09
BR0114157A (pt) 2003-07-29

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees