HUP0302755A2 - Eljárás kamptotecin-analóg vegyületek előállítására - Google Patents

Eljárás kamptotecin-analóg vegyületek előállítására

Info

Publication number
HUP0302755A2
HUP0302755A2 HU0302755A HUP0302755A HUP0302755A2 HU P0302755 A2 HUP0302755 A2 HU P0302755A2 HU 0302755 A HU0302755 A HU 0302755A HU P0302755 A HUP0302755 A HU P0302755A HU P0302755 A2 HUP0302755 A2 HU P0302755A2
Authority
HU
Hungary
Prior art keywords
compound
general formula
formula
converted
camptothecin
Prior art date
Application number
HU0302755A
Other languages
English (en)
Inventor
Hiroyuki Nishiyama
Takanori Ogawa
Seigo Sawada
Miyuki Uchida
Original Assignee
Kabushiki Kaisha Yakult Honsha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisha Yakult Honsha filed Critical Kabushiki Kaisha Yakult Honsha
Publication of HUP0302755A2 publication Critical patent/HUP0302755A2/hu
Publication of HUP0302755A3 publication Critical patent/HUP0302755A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya eljárás kamptotecin-analógok szintéziséhezhasználható (e) képletű 2'-amino-5'-hidroxi-propiofenon előállítására,amelynek során az (a) képletű vegyületet (b) általános képletűvegyületté alakítják, a (b) általános képletű vegyületet (c) általánosképletű vegyületté alakítják, a (c) általános képletű vegyületet (d)általános képletű vegyületté alakítják, és a (d) általános képletűvegyületet az (e) képletű 2'-amino-5'-hidroxi-propiofenonná alakítják- a képletekben R katalitikus redukcióval lehasítható védőcsoportotjelent. A találmány tárgya továbbá eljárás kamptotecin-analógokszintéziséhez használható (h) képletű triciklusos keton előállításárajavított módszerrel. Az (e) és (h) képletű vegyületek reagáltatásávalés szükség szerinti utólagos átalakításokkal a kamptotecin-analógokigen jó hatásfokkal állíthatók elő. Ó
HU0302755A 2001-02-21 2002-02-21 Method of synthesizing camptothecin-relating compounds HUP0302755A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001045430 2001-02-21
JP2001309322 2001-10-05
PCT/JP2002/001538 WO2002066416A1 (en) 2001-02-21 2002-02-21 Method of synthesizing camptothecin-relating compounds

Publications (2)

Publication Number Publication Date
HUP0302755A2 true HUP0302755A2 (hu) 2003-12-29
HUP0302755A3 HUP0302755A3 (en) 2008-03-28

Family

ID=26609837

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302755A HUP0302755A3 (en) 2001-02-21 2002-02-21 Method of synthesizing camptothecin-relating compounds

Country Status (23)

Country Link
US (2) US7126000B2 (hu)
EP (1) EP1378505B1 (hu)
JP (2) JP4210119B2 (hu)
KR (2) KR100858972B1 (hu)
CN (1) CN100408550C (hu)
AR (2) AR035684A1 (hu)
AU (1) AU2002237527B2 (hu)
BG (2) BG108031A (hu)
BR (1) BR0207470A (hu)
CA (2) CA2683768C (hu)
CZ (1) CZ20032470A3 (hu)
EE (1) EE05361B1 (hu)
HU (1) HUP0302755A3 (hu)
IL (2) IL156949A0 (hu)
MX (1) MXPA03007528A (hu)
NO (2) NO328628B1 (hu)
NZ (2) NZ527615A (hu)
PL (2) PL217238B1 (hu)
RO (2) RO125158A2 (hu)
RU (1) RU2308447C2 (hu)
SK (2) SK288149B6 (hu)
TW (1) TWI245768B (hu)
WO (1) WO2002066416A1 (hu)

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JP5599094B2 (ja) * 2010-05-20 2014-10-01 国立大学法人 千葉大学 ニトリル化合物の製造方法
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CN109416937A (zh) 2016-06-24 2019-03-01 波士顿科学神经调制公司 用于临床效果的视觉分析的系统和方法
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AU2017341910B2 (en) 2016-10-14 2020-05-14 Boston Scientific Neuromodulation Corporation Systems and methods for closed-loop determination of stimulation parameter settings for an electrical simulation system
AU2017391436B2 (en) 2017-01-03 2020-06-18 Boston Scientific Neuromodulation Corporation Systems and methods for selecting MRI-compatible stimulation parameters
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Also Published As

Publication number Publication date
PL399009A1 (pl) 2012-09-10
SK288073B6 (sk) 2013-05-03
AU2002237527B2 (en) 2007-01-04
JPWO2002066416A1 (ja) 2004-09-24
MXPA03007528A (es) 2003-12-11
EP1378505B1 (en) 2014-11-05
KR100858972B1 (ko) 2008-09-17
RU2003128530A (ru) 2005-03-27
NO20093402L (no) 2003-10-10
EP1378505A1 (en) 2004-01-07
KR20030077631A (ko) 2003-10-01
KR20080012383A (ko) 2008-02-11
US7126000B2 (en) 2006-10-24
EE05361B1 (et) 2010-12-15
HUP0302755A3 (en) 2008-03-28
IL156949A0 (en) 2004-02-08
JP4210119B2 (ja) 2009-01-14
WO2002066416A1 (en) 2002-08-29
EP1378505A4 (en) 2006-09-27
AR082663A2 (es) 2012-12-26
NO20033579L (no) 2003-10-10
SK288149B6 (sk) 2013-12-02
RO122639B1 (ro) 2009-10-30
NZ527615A (en) 2004-12-24
CA2683768A1 (en) 2002-08-29
US20070010674A1 (en) 2007-01-11
BG111453A (en) 2013-09-30
RO125158A2 (ro) 2010-01-29
US7378555B2 (en) 2008-05-27
BG108031A (bg) 2005-04-30
CA2683768C (en) 2013-05-28
PL363440A1 (en) 2004-11-15
JP2008273952A (ja) 2008-11-13
SK11472003A3 (sk) 2004-03-02
CN1492851A (zh) 2004-04-28
RO122639B9 (ro) 2014-03-28
NO20033579D0 (no) 2003-08-13
US20040106830A1 (en) 2004-06-03
CZ20032470A3 (cs) 2004-02-18
EE200300373A (et) 2003-10-15
PL218065B1 (pl) 2014-10-31
PL217238B1 (pl) 2014-06-30
TWI245768B (en) 2005-12-21
AR035684A1 (es) 2004-06-23
IL156949A (en) 2009-09-01
NO328628B1 (no) 2010-04-12
CN100408550C (zh) 2008-08-06
JP4805967B2 (ja) 2011-11-02
CA2437702A1 (en) 2002-08-29
BR0207470A (pt) 2008-04-08
KR100864692B1 (ko) 2008-10-23
NO331656B1 (no) 2012-02-13
NZ534374A (en) 2004-12-24
RU2308447C2 (ru) 2007-10-20
CA2437702C (en) 2010-04-06

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