AR082663A2 - Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina - Google Patents

Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina

Info

Publication number
AR082663A2
AR082663A2 ARP110102927A ARP110102927A AR082663A2 AR 082663 A2 AR082663 A2 AR 082663A2 AR P110102927 A ARP110102927 A AR P110102927A AR P110102927 A ARP110102927 A AR P110102927A AR 082663 A2 AR082663 A2 AR 082663A2
Authority
AR
Argentina
Prior art keywords
compound
formula
group
produced
tms
Prior art date
Application number
ARP110102927A
Other languages
English (en)
Inventor
Seigo Sawada
Miyuki Uchida
Takanori Ogawa
Hiroyuki Nishiyama
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of AR082663A2 publication Critical patent/AR082663A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un procedimiento para preparar una cetona tricíclica, correspondiente a la parte CDE del anillo de la camptotecina (CPT), la cual es un material de partida para el clorhidrato de irinotecan y diversos tipos de derivados de camptotecina.Reivindicación 1: Un procedimiento para preparar una cetona tricíclica para sintetizar análogos de camptotecina, en donde a partir del compuesto de fórmula (1) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo), o del compuesto de fórmula (2) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo), se produce el compuesto de fórmula (3) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo); y a partir del compuesto de fórmula (3), se produce el compuesto de fórmula (4) (en donde TMS es un grupo trimetilsililo, y Me es un grupo metilo); y a partir del compuesto de fórmula (4), se produce el compuesto de fórmula (5) (en donde TMS es un grupo trimetilsililo, Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (5), se produce el compuesto de fórmula (6) (en donde TMS es un grupo trimetilsililo, Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (6), se produce el compuesto de fórmula (7) (en donde TMS es un grupo trimetilsililo, Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (7), se produce el compuesto de fórmula (8) (en donde Me es un grupo metilo, y Et es un grupo etilo); y a partir del compuesto de fórmula (8), se produce el compuesto de fórmula (9) (en donde Me es un grupo metilo, Et es un grupo etilo y Pr es un grupo propilo); y a partir del compuesto de fórmula (9), se obtiene el compuesto de fórmula (10) (en donde Et es un grupo etilo y Pr es un grupo propilo); y a partir del compuesto de fórmula (10), se produce el compuesto de fórmula (11) (en donde Et es un grupo etilo, y tBu es un grupo t-butilo); y a partir del compuesto de fórmula (11), se produce el compuesto de fórmula (12) (en donde Et es un grupo etilo), caracterizado porque la mejora comprende una etapa (i) para obtener el compuesto de fórmula (3) que comprende mezclar el compuesto de fórmula (1), un agente litiante, un reactivo de formilación y un reactivo de iodación.
ARP110102927A 2001-02-21 2011-08-11 Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina AR082663A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001045430 2001-02-21
JP2001309322 2001-10-05

Publications (1)

Publication Number Publication Date
AR082663A2 true AR082663A2 (es) 2012-12-26

Family

ID=26609837

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP020100579A AR035684A1 (es) 2001-02-21 2002-02-20 Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
ARP110102927A AR082663A2 (es) 2001-02-21 2011-08-11 Procedimiento para sintetizar compuesto(s) relacionado(s) con camptotecina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP020100579A AR035684A1 (es) 2001-02-21 2002-02-20 Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina

Country Status (23)

Country Link
US (2) US7126000B2 (es)
EP (1) EP1378505B1 (es)
JP (2) JP4210119B2 (es)
KR (2) KR100858972B1 (es)
CN (1) CN100408550C (es)
AR (2) AR035684A1 (es)
AU (1) AU2002237527B2 (es)
BG (2) BG108031A (es)
BR (1) BR0207470A (es)
CA (2) CA2683768C (es)
CZ (1) CZ20032470A3 (es)
EE (1) EE05361B1 (es)
HU (1) HUP0302755A3 (es)
IL (2) IL156949A0 (es)
MX (1) MXPA03007528A (es)
NO (2) NO328628B1 (es)
NZ (2) NZ527615A (es)
PL (2) PL217238B1 (es)
RO (2) RO125158A2 (es)
RU (1) RU2308447C2 (es)
SK (2) SK288149B6 (es)
TW (1) TWI245768B (es)
WO (1) WO2002066416A1 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
EP1791846A1 (en) * 2004-08-09 2007-06-06 Shilpa Medicare Limited An improved process for the preparation of irinotecan hydrochloride trihydrate
KR100848919B1 (ko) * 2004-11-05 2008-07-29 주식회사 삼양사 10-히드록시캄토테신 화합물의 극성 비수성 용매에 대한용해도를 증가시키기 위한 약제학적 제형
CA2591081C (en) * 2005-02-07 2014-10-28 Fermion Oy Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin
US7767813B2 (en) 2005-02-08 2010-08-03 Fermion Oy Preparation method
US7662964B2 (en) * 2005-02-08 2010-02-16 Fermion Oy Process for producing [1,4′] bipiperidinyl-1′-carbonyl chloride or hydrochloride thereof
US8112154B2 (en) * 2005-04-13 2012-02-07 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
TWI375678B (en) * 2005-06-09 2012-11-01 Yakult Honsha Kk A method of preparation of a tricyclic ketone
ES2432553T3 (es) * 2005-08-03 2013-12-04 Avra Laboratories Pvt. Ltd. Procedimiento de síntesis de intermedios clave para la producción de derivados de camptotecina
EP1803725A1 (en) * 2005-12-13 2007-07-04 W.C. Heraeus GmbH Methods for preparing irinotecan
US9220889B2 (en) 2008-02-11 2015-12-29 Intelect Medical, Inc. Directional electrode devices with locating features
CN101824038B (zh) * 2009-03-06 2013-08-21 复旦大学 喜树碱及其类似物的制备方法
WO2011025865A1 (en) 2009-08-27 2011-03-03 The Cleveland Clinic Foundation System and method to estimate region of tissue activation
JP5599094B2 (ja) * 2010-05-20 2014-10-01 国立大学法人 千葉大学 ニトリル化合物の製造方法
AU2011267853B2 (en) 2010-06-14 2016-12-08 Boston Scientific Neuromodulation Corporation Programming interface for spinal cord neuromodulation
US9925382B2 (en) 2011-08-09 2018-03-27 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing
WO2014036079A2 (en) 2012-08-28 2014-03-06 Boston Scientific Neuromodulation Corporation Parameter visualization, selection, and annotation interface
WO2014070290A2 (en) 2012-11-01 2014-05-08 Boston Scientific Neuromodulation Corporation Systems and methods for voa model generation and use
US8722886B1 (en) * 2012-11-13 2014-05-13 Bionumerik Pharmaceuticals, Inc. Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
US9959388B2 (en) 2014-07-24 2018-05-01 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for providing electrical stimulation therapy feedback
US10265528B2 (en) 2014-07-30 2019-04-23 Boston Scientific Neuromodulation Corporation Systems and methods for electrical stimulation-related patient population volume analysis and use
US10272247B2 (en) 2014-07-30 2019-04-30 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming
WO2016057544A1 (en) 2014-10-07 2016-04-14 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters
CN107428770B (zh) * 2014-10-22 2019-10-01 维瓦西塔斯肿瘤学公司 用于喜树碱类似物合成的方法和体系
AU2016268259B2 (en) 2015-05-26 2019-01-31 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
US20160375248A1 (en) 2015-06-29 2016-12-29 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects
US10441800B2 (en) 2015-06-29 2019-10-15 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters by targeting and steering
WO2017062378A1 (en) 2015-10-09 2017-04-13 Boston Scientific Neuromodulation Corporation System and methods for clinical effects mapping for directional stimulations leads
US10716942B2 (en) 2016-04-25 2020-07-21 Boston Scientific Neuromodulation Corporation System and methods for directional steering of electrical stimulation
WO2017223505A2 (en) 2016-06-24 2017-12-28 Boston Scientific Neuromodulation Corporation Systems and methods for visual analytics of clinical effects
WO2018044881A1 (en) 2016-09-02 2018-03-08 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and directing stimulation of neural elements
US10780282B2 (en) 2016-09-20 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters
AU2017341910B2 (en) 2016-10-14 2020-05-14 Boston Scientific Neuromodulation Corporation Systems and methods for closed-loop determination of stimulation parameter settings for an electrical simulation system
AU2017391436B2 (en) 2017-01-03 2020-06-18 Boston Scientific Neuromodulation Corporation Systems and methods for selecting MRI-compatible stimulation parameters
ES2821752T3 (es) 2017-01-10 2021-04-27 Boston Scient Neuromodulation Corp Sistemas y procedimientos para crear programas de estimulación en base a áreas o volúmenes definidos por el usuario
US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
US11357986B2 (en) 2017-04-03 2022-06-14 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
AU2018301355B2 (en) 2017-07-14 2020-10-01 Boston Scientific Neuromodulation Corporation Systems and methods for estimating clinical effects of electrical stimulation
US10960214B2 (en) 2017-08-15 2021-03-30 Boston Scientific Neuromodulation Corporation Systems and methods for controlling electrical stimulation using multiple stimulation fields
EP3784332B1 (en) 2018-04-27 2023-04-26 Boston Scientific Neuromodulation Corporation Systems for visualizing and programming electrical stimulation
AU2019260740B2 (en) 2018-04-27 2022-05-19 Boston Scientific Neuromodulation Corporation Multi-mode electrical stimulation systems and methods of making and using
US11434196B2 (en) * 2019-01-15 2022-09-06 Laurus Labs Limited Process for preparation of 2-Amino-5-hydroxy propiophenone

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
JPH07101956A (ja) * 1993-10-05 1995-04-18 Tanabe Seiyaku Co Ltd ヒドロキシカンプトテシン化合物の製法
KR960029336A (ko) * 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
JPH08225482A (ja) * 1995-02-22 1996-09-03 Dai Ichi Seiyaku Co Ltd テトラロン関連化合物及びその製法
IL117684A (en) 1995-04-07 2002-02-10 Pharmacia & Upjohn Inc Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds
WO1997016454A1 (en) 1995-11-02 1997-05-09 Glaxo Wellcome Inc. Method for preparing camptothecin derivatives
SG104284A1 (en) * 1996-10-30 2004-06-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof

Also Published As

Publication number Publication date
RU2003128530A (ru) 2005-03-27
EE05361B1 (et) 2010-12-15
JP2008273952A (ja) 2008-11-13
MXPA03007528A (es) 2003-12-11
JP4210119B2 (ja) 2009-01-14
IL156949A0 (en) 2004-02-08
EP1378505A4 (en) 2006-09-27
KR100858972B1 (ko) 2008-09-17
HUP0302755A2 (hu) 2003-12-29
EP1378505B1 (en) 2014-11-05
EE200300373A (et) 2003-10-15
US20040106830A1 (en) 2004-06-03
NO331656B1 (no) 2012-02-13
PL217238B1 (pl) 2014-06-30
TWI245768B (en) 2005-12-21
CA2437702A1 (en) 2002-08-29
BR0207470A (pt) 2008-04-08
US7126000B2 (en) 2006-10-24
NO20093402L (no) 2003-10-10
RO125158A2 (ro) 2010-01-29
RO122639B1 (ro) 2009-10-30
JP4805967B2 (ja) 2011-11-02
NO328628B1 (no) 2010-04-12
SK288073B6 (sk) 2013-05-03
NZ534374A (en) 2004-12-24
CZ20032470A3 (cs) 2004-02-18
BG111453A (en) 2013-09-30
SK288149B6 (sk) 2013-12-02
PL399009A1 (pl) 2012-09-10
EP1378505A1 (en) 2004-01-07
AU2002237527B2 (en) 2007-01-04
CA2683768A1 (en) 2002-08-29
AR035684A1 (es) 2004-06-23
SK11472003A3 (sk) 2004-03-02
HUP0302755A3 (en) 2008-03-28
BG108031A (bg) 2005-04-30
RO122639B9 (ro) 2014-03-28
PL218065B1 (pl) 2014-10-31
IL156949A (en) 2009-09-01
NO20033579L (no) 2003-10-10
CN1492851A (zh) 2004-04-28
KR20030077631A (ko) 2003-10-01
PL363440A1 (en) 2004-11-15
US7378555B2 (en) 2008-05-27
KR100864692B1 (ko) 2008-10-23
JPWO2002066416A1 (ja) 2004-09-24
RU2308447C2 (ru) 2007-10-20
NO20033579D0 (no) 2003-08-13
CA2437702C (en) 2010-04-06
KR20080012383A (ko) 2008-02-11
CN100408550C (zh) 2008-08-06
NZ527615A (en) 2004-12-24
CA2683768C (en) 2013-05-28
WO2002066416A1 (en) 2002-08-29
US20070010674A1 (en) 2007-01-11

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