DE69915965D1 - Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid - Google Patents

Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid

Info

Publication number
DE69915965D1
DE69915965D1 DE69915965T DE69915965T DE69915965D1 DE 69915965 D1 DE69915965 D1 DE 69915965D1 DE 69915965 T DE69915965 T DE 69915965T DE 69915965 T DE69915965 T DE 69915965T DE 69915965 D1 DE69915965 D1 DE 69915965D1
Authority
DE
Germany
Prior art keywords
budesonide
alpha
epimer
iodo
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69915965T
Other languages
English (en)
Other versions
DE69915965T2 (de
Inventor
Loggia Filippo La
Pierfranco Dotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmabios SpA
Original Assignee
Farmabios SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmabios SpA filed Critical Farmabios SpA
Application granted granted Critical
Publication of DE69915965D1 publication Critical patent/DE69915965D1/de
Publication of DE69915965T2 publication Critical patent/DE69915965T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69915965T 1998-10-13 1999-10-12 Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid Expired - Fee Related DE69915965T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI982196 1998-10-13
IT1998MI002196A IT1302657B1 (it) 1998-10-13 1998-10-13 Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r.

Publications (2)

Publication Number Publication Date
DE69915965D1 true DE69915965D1 (de) 2004-05-06
DE69915965T2 DE69915965T2 (de) 2005-03-17

Family

ID=11380860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69915965T Expired - Fee Related DE69915965T2 (de) 1998-10-13 1999-10-12 Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid

Country Status (8)

Country Link
EP (1) EP0994119B1 (de)
JP (1) JP2000128897A (de)
AT (1) ATE263184T1 (de)
DE (1) DE69915965T2 (de)
DK (1) DK0994119T3 (de)
ES (1) ES2218929T3 (de)
IT (1) IT1302657B1 (de)
PT (1) PT994119E (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012260D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition
US20100331539A1 (en) * 2008-03-13 2010-12-30 Farmabios S.P.A. Process for the preparation of pregnane derivatives
CN111018932B (zh) * 2019-11-28 2021-07-02 奥锐特药业股份有限公司 一种甾体化合物9-位脱卤的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
FR2675146A1 (fr) * 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
IT1291288B1 (it) * 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.

Also Published As

Publication number Publication date
DK0994119T3 (da) 2004-08-02
ATE263184T1 (de) 2004-04-15
EP0994119A1 (de) 2000-04-19
IT1302657B1 (it) 2000-09-29
EP0994119B1 (de) 2004-03-31
JP2000128897A (ja) 2000-05-09
DE69915965T2 (de) 2005-03-17
ES2218929T3 (es) 2004-11-16
PT994119E (pt) 2004-08-31
ITMI982196A1 (it) 2000-04-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee