DE60114889D1 - Verfahren zur herstellung von fluconazole und kristallmodifikationen davon - Google Patents
Verfahren zur herstellung von fluconazole und kristallmodifikationen davonInfo
- Publication number
- DE60114889D1 DE60114889D1 DE60114889T DE60114889T DE60114889D1 DE 60114889 D1 DE60114889 D1 DE 60114889D1 DE 60114889 T DE60114889 T DE 60114889T DE 60114889 T DE60114889 T DE 60114889T DE 60114889 D1 DE60114889 D1 DE 60114889D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- sup
- fluconazole
- preparation
- crystal modifications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960004884 fluconazole Drugs 0.000 title abstract 3
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000012986 modification Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
- -1 fluconazole monohydrate Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/HU2001/000033 WO2002076955A1 (en) | 2001-03-23 | 2001-03-23 | Process for preparing fluconazole and its crystal modifications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60114889D1 true DE60114889D1 (de) | 2005-12-15 |
| DE60114889T2 DE60114889T2 (de) | 2006-07-20 |
Family
ID=10974115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60114889T Expired - Lifetime DE60114889T2 (de) | 2001-03-23 | 2001-03-23 | Verfahren zur herstellung von fluconazole und kristallmodifikationen davon |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7094904B2 (de) |
| EP (1) | EP1373227B1 (de) |
| JP (1) | JP2004524348A (de) |
| AT (1) | ATE309226T1 (de) |
| BG (1) | BG66152B1 (de) |
| CA (1) | CA2439310C (de) |
| CZ (1) | CZ304213B6 (de) |
| DE (1) | DE60114889T2 (de) |
| ES (1) | ES2252209T3 (de) |
| HR (1) | HRP20030854B1 (de) |
| HU (1) | HU226886B1 (de) |
| PL (1) | PL211572B1 (de) |
| SK (1) | SK287354B6 (de) |
| WO (1) | WO2002076955A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011101862A1 (en) | 2010-02-17 | 2011-08-25 | Fdc Limited | Stabilized fluconazole polymorph iii formulation |
| CN102276543A (zh) * | 2011-07-13 | 2011-12-14 | 王健祥 | 一种氟康唑的精制方法 |
| CN107935947A (zh) * | 2018-01-04 | 2018-04-20 | 苏州天马药业有限公司 | 一种氟康唑晶型ⅲ的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2078719B (en) * | 1980-06-02 | 1984-04-26 | Ici Ltd | Heterocyclic compounds |
| GB2099818A (en) * | 1981-06-06 | 1982-12-15 | Pfizer Ltd | Triazoles |
| DE3262386D1 (en) * | 1981-06-06 | 1985-03-28 | Pfizer Ltd | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| ES8604938A1 (es) * | 1985-11-19 | 1986-03-01 | Inke Sa | Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol |
| ES8604940A1 (es) * | 1985-11-19 | 1986-03-01 | Inke Sa | Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol. |
| ES8604939A1 (es) * | 1985-11-19 | 1986-03-01 | Inke Sa | Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol |
| ES8605753A1 (es) * | 1985-12-06 | 1986-04-16 | Lazlo Int Sa | Procedimiento de sintesis de un alcohol terciario |
| GB8618846D0 (en) * | 1986-08-01 | 1986-09-10 | Smithkline Beckman Corp | Chemical process |
| IT1249211B (it) * | 1990-06-08 | 1995-02-20 | Ind Chimica Srl | Processo per la preparazione di triazolil isopropanoli in particolare fluconazolo |
| TW218017B (de) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
| GB2270521A (en) * | 1992-09-09 | 1994-03-16 | Pfizer | Crystalline monohydrate of 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol |
| HU212424B (en) * | 1993-09-23 | 1996-06-28 | Richter Gedeon Vegyeszet | New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them |
| HU212458B (en) * | 1993-09-23 | 1996-06-28 | Richter Gedeon Vegyeszet | New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them |
| CA2139079C (en) * | 1994-12-23 | 1996-05-28 | K.S. Keshava Murthy | Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof |
| CN1196730A (zh) * | 1996-06-19 | 1998-10-21 | 雷迪博士研究基金会 | 具有增强的抗糖尿病活性的穴糖酮的新的多晶型形式及其制备方法 |
| KR100194945B1 (ko) * | 1997-01-29 | 1999-06-15 | 서치영 | 플루코나졸의 제조방법 |
-
2001
- 2001-03-23 ES ES01921683T patent/ES2252209T3/es not_active Expired - Lifetime
- 2001-03-23 CZ CZ2003-2575A patent/CZ304213B6/cs not_active IP Right Cessation
- 2001-03-23 PL PL363756A patent/PL211572B1/pl not_active IP Right Cessation
- 2001-03-23 JP JP2002576215A patent/JP2004524348A/ja active Pending
- 2001-03-23 CA CA002439310A patent/CA2439310C/en not_active Expired - Fee Related
- 2001-03-23 DE DE60114889T patent/DE60114889T2/de not_active Expired - Lifetime
- 2001-03-23 AT AT01921683T patent/ATE309226T1/de not_active IP Right Cessation
- 2001-03-23 SK SK1239-2003A patent/SK287354B6/sk not_active IP Right Cessation
- 2001-03-23 WO PCT/HU2001/000033 patent/WO2002076955A1/en active IP Right Grant
- 2001-03-23 EP EP01921683A patent/EP1373227B1/de not_active Expired - Lifetime
- 2001-03-23 HU HU0500796A patent/HU226886B1/hu unknown
-
2003
- 2003-09-11 BG BG108172A patent/BG66152B1/bg unknown
- 2003-09-22 US US10/667,201 patent/US7094904B2/en not_active Expired - Fee Related
- 2003-10-20 HR HR20030854A patent/HRP20030854B1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2439310C (en) | 2009-09-29 |
| CZ304213B6 (cs) | 2014-01-08 |
| SK12392003A3 (sk) | 2004-02-03 |
| EP1373227A1 (de) | 2004-01-02 |
| ATE309226T1 (de) | 2005-11-15 |
| BG108172A (en) | 2004-07-30 |
| HRP20030854A2 (en) | 2005-08-31 |
| HRP20030854A9 (hr) | 2011-09-30 |
| HUP0500796A3 (en) | 2007-06-28 |
| CA2439310A1 (en) | 2002-10-03 |
| US20040106804A1 (en) | 2004-06-03 |
| EP1373227B1 (de) | 2005-11-09 |
| PL211572B1 (pl) | 2012-05-31 |
| DE60114889T2 (de) | 2006-07-20 |
| HUP0500796A2 (hu) | 2005-12-28 |
| JP2004524348A (ja) | 2004-08-12 |
| US7094904B2 (en) | 2006-08-22 |
| SK287354B6 (sk) | 2010-08-09 |
| PL363756A1 (en) | 2004-11-29 |
| WO2002076955A1 (en) | 2002-10-03 |
| ES2252209T3 (es) | 2006-05-16 |
| CZ20032575A3 (cs) | 2003-12-17 |
| HRP20030854B1 (en) | 2011-11-30 |
| BG66152B1 (bg) | 2011-08-31 |
| HU226886B1 (en) | 2010-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |