ES8604939A1 - Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol - Google Patents
Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-olInfo
- Publication number
- ES8604939A1 ES8604939A1 ES549021A ES549021A ES8604939A1 ES 8604939 A1 ES8604939 A1 ES 8604939A1 ES 549021 A ES549021 A ES 549021A ES 549021 A ES549021 A ES 549021A ES 8604939 A1 ES8604939 A1 ES 8604939A1
- Authority
- ES
- Spain
- Prior art keywords
- propan
- bis
- prepn
- difluorophenyl
- triazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DEL 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL. COMPRENDE: A) HACER REACCIONAR AL ESTER METILICO DEL ACIDO 2,4-DIFLUOROBENZOICO DE FORMULA (II) CON UN COMPUESTO ORGANOMETALICO DE FORMULA (III), EN UNA RELACION DE (III/II) (2:1), EN TETRAHIDROFURANO, DIOXANO O HEXANO, Y A UNA TEMPERATURA ENTRE 0JC Y LA DE REFLUJO DEL DISOLVENTE, PARA OBTENER LA 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL DE FORMULA (I); Y B) RECRISTALIZAR A (I) EN ISOPROPANOL O ACETATO DE ETILO, PARA OBTENERLO QUIMICAMENTE PURO. SIENDO: X, CL, BR O YODO. SE UTILIZAN COMO ANTIFUNGICOS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES549021A ES8604939A1 (es) | 1985-11-19 | 1985-11-19 | Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES549021A ES8604939A1 (es) | 1985-11-19 | 1985-11-19 | Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604939A1 true ES8604939A1 (es) | 1986-03-01 |
ES549021A0 ES549021A0 (es) | 1986-03-01 |
Family
ID=8490207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549021A Expired ES8604939A1 (es) | 1985-11-19 | 1985-11-19 | Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8604939A1 (es) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049663A1 (es) * | 1992-10-13 | 1994-04-16 | Genesis Para La Investigacion | Procedimiento de obtencion de fluconazol. |
AT400145B (de) * | 1990-06-08 | 1995-10-25 | Ind Chimica Srl | Verfahren zur herstellung von triazolyl-isopropanolen |
BG66152B1 (bg) * | 2001-03-23 | 2011-08-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Метод за получаване на флуконазол и неговите кристални модификации |
CN102344419A (zh) * | 2011-09-16 | 2012-02-08 | 浙江金伯士药业有限公司 | 广谱抗真菌药氟康唑的制备方法 |
-
1985
- 1985-11-19 ES ES549021A patent/ES8604939A1/es not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400145B (de) * | 1990-06-08 | 1995-10-25 | Ind Chimica Srl | Verfahren zur herstellung von triazolyl-isopropanolen |
ES2049663A1 (es) * | 1992-10-13 | 1994-04-16 | Genesis Para La Investigacion | Procedimiento de obtencion de fluconazol. |
BG66152B1 (bg) * | 2001-03-23 | 2011-08-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Метод за получаване на флуконазол и неговите кристални модификации |
CN102344419A (zh) * | 2011-09-16 | 2012-02-08 | 浙江金伯士药业有限公司 | 广谱抗真菌药氟康唑的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
ES549021A0 (es) | 1986-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20051207 |