JPS57134417A - Cardiotonic agent - Google Patents

Cardiotonic agent

Info

Publication number
JPS57134417A
JPS57134417A JP56020490A JP2049081A JPS57134417A JP S57134417 A JPS57134417 A JP S57134417A JP 56020490 A JP56020490 A JP 56020490A JP 2049081 A JP2049081 A JP 2049081A JP S57134417 A JPS57134417 A JP S57134417A
Authority
JP
Japan
Prior art keywords
formula
agent
phenylthiazole
phenylacetaldehyde
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56020490A
Other languages
Japanese (ja)
Other versions
JPH024577B2 (en
Inventor
Tsuneo Okonogi
Shunzo Fukatsu
Mitsugi Hachisu
Hiroko Kawashima
Keiko Shito
Taiji Sekizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP56020490A priority Critical patent/JPS57134417A/en
Priority to US06/345,672 priority patent/US4418070A/en
Priority to FR8202257A priority patent/FR2499853B1/en
Priority to DE19823204732 priority patent/DE3204732A1/en
Priority to IT19647/82A priority patent/IT1157267B/en
Priority to GB8204233A priority patent/GB2094143B/en
Publication of JPS57134417A publication Critical patent/JPS57134417A/en
Publication of JPH024577B2 publication Critical patent/JPH024577B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PURPOSE: A cardiotonic agent, containing a specific 5-phenylthiazole derivative or a salt thereof as an active constituent, capable of remarkably increasing the atrial contractive force but with almost no remarkable or no effect on auriculoventricular rhythm.
CONSTITUTION: A caridotonic agent, containing a 5-phenylthiazole derivative of the formula (R is H, lower alkyl, OH, NH2 or mercapto) or a salt thereof as an active consitutent, and applicable as an intravenous injection or oral agent. The compound of the formula is obtained by reacting phenylacetaldehyde with bromine, and reacting the resultant intermediate α-bromo-α-phenylacetaldehyde with a thioformamide, thioacetamide, etc. A compound of the formula (R is OH), i.e. 2-hydroxy-5-phenylthiazole, is a novel substance.
COPYRIGHT: (C)1982,JPO&Japio
JP56020490A 1981-02-14 1981-02-14 Cardiotonic agent Granted JPS57134417A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP56020490A JPS57134417A (en) 1981-02-14 1981-02-14 Cardiotonic agent
US06/345,672 US4418070A (en) 1981-02-14 1982-02-04 Cardiotonic agents
FR8202257A FR2499853B1 (en) 1981-02-14 1982-02-11 CARDIOTONIC AGENTS BASED ON 5-PHENYLTHIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH AN AGENT
DE19823204732 DE3204732A1 (en) 1981-02-14 1982-02-11 HEART TONIC
IT19647/82A IT1157267B (en) 1981-02-14 1982-02-12 CARDIOSTIMULANT OR CARDIOTONIC AGENT
GB8204233A GB2094143B (en) 1981-02-14 1982-02-12 Compositions containing 5-phenylthiazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56020490A JPS57134417A (en) 1981-02-14 1981-02-14 Cardiotonic agent

Publications (2)

Publication Number Publication Date
JPS57134417A true JPS57134417A (en) 1982-08-19
JPH024577B2 JPH024577B2 (en) 1990-01-29

Family

ID=12028583

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56020490A Granted JPS57134417A (en) 1981-02-14 1981-02-14 Cardiotonic agent

Country Status (6)

Country Link
US (1) US4418070A (en)
JP (1) JPS57134417A (en)
DE (1) DE3204732A1 (en)
FR (1) FR2499853B1 (en)
GB (1) GB2094143B (en)
IT (1) IT1157267B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043373A (en) * 1995-07-12 2000-03-28 Yungjin Pharmaceutical Co., Ltd. Heterocycle-fused thiazole derivatives

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
US4734422A (en) * 1985-10-15 1988-03-29 Merrell Dow Pharmaceuticals Inc. Cardiotonic aroylthiazolones and the use thereof
US4670450A (en) * 1985-11-13 1987-06-02 Merrell Dow Pharmaceuticals Inc. Cardiotonic thiazolones
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
DE102010045797A1 (en) * 2010-09-20 2012-03-22 Klinikum Darmstadt Gmbh Compounds for the diagnosis of neurodegenerative diseases of the olfactory epithelium

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2132431A1 (en) * 1971-06-30 1973-01-11 Riedel De Haen Ag PHARMACEUTICAL PREPARATIONS CONTAINING 4-PHENYL-THIAZOLE DERIVATIVES
BE790569A (en) * 1971-10-27 1973-04-26 Syntex Corp THIAZOLA-BASED CARDIOVASCULAR AGENTS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043373A (en) * 1995-07-12 2000-03-28 Yungjin Pharmaceutical Co., Ltd. Heterocycle-fused thiazole derivatives

Also Published As

Publication number Publication date
FR2499853B1 (en) 1985-11-22
DE3204732C2 (en) 1991-04-11
GB2094143A (en) 1982-09-15
JPH024577B2 (en) 1990-01-29
DE3204732A1 (en) 1982-09-09
FR2499853A1 (en) 1982-08-20
US4418070A (en) 1983-11-29
IT8219647A0 (en) 1982-02-12
GB2094143B (en) 1984-12-19
IT1157267B (en) 1987-02-11

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