ES8604940A1 - Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol. - Google Patents

Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol.

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Publication number
ES8604940A1
ES8604940A1 ES549022A ES549022A ES8604940A1 ES 8604940 A1 ES8604940 A1 ES 8604940A1 ES 549022 A ES549022 A ES 549022A ES 549022 A ES549022 A ES 549022A ES 8604940 A1 ES8604940 A1 ES 8604940A1
Authority
ES
Spain
Prior art keywords
propan
bis
prepn
difluorophenyl
triazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549022A
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English (en)
Other versions
ES549022A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inke SA
Original Assignee
Inke SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke SA filed Critical Inke SA
Priority to ES549022A priority Critical patent/ES8604940A1/es
Publication of ES549022A0 publication Critical patent/ES549022A0/es
Publication of ES8604940A1 publication Critical patent/ES8604940A1/es
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL. COMPRENDE: A) HACER REACCIONAR A LA 2,40DIFLUORO-2-(1H-1,2,4-TRIAZOL-1-IL)ACETOFENONA DE FORMULA (II) CON UN COMPUESTO ORGANOMETALICO DE FORMULA (III) EN TETRAHIDROFURANO, ETER DIETILICO O DIOXANO Y ENTRE 10 Y 40JC, PARA OBTENER EL 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL DE FORMULA (I); Y B) CRISTALIZAR (I) EN ISOPROPANOL O ACETATO DE ATILO, PARA PRODUCIR 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL QUIMICAMENTE PURO. SIENDO S, CLORO, BROMO O YODO. SE UTILIZAN COMO ANTIFUNGICOS.
ES549022A 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol. Expired ES8604940A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES549022A ES8604940A1 (es) 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES549022A ES8604940A1 (es) 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol.

Publications (2)

Publication Number Publication Date
ES549022A0 ES549022A0 (es) 1986-03-01
ES8604940A1 true ES8604940A1 (es) 1986-03-01

Family

ID=8490208

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549022A Expired ES8604940A1 (es) 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol.

Country Status (1)

Country Link
ES (1) ES8604940A1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049663A1 (es) * 1992-10-13 1994-04-16 Genesis Para La Investigacion Procedimiento de obtencion de fluconazol.
AT400145B (de) * 1990-06-08 1995-10-25 Ind Chimica Srl Verfahren zur herstellung von triazolyl-isopropanolen
WO2002076955A1 (en) * 2001-03-23 2002-10-03 Richter Gedeon Vegyeszéti Gyár Rt. Process for preparing fluconazole and its crystal modifications
CN102344419A (zh) * 2011-09-16 2012-02-08 浙江金伯士药业有限公司 广谱抗真菌药氟康唑的制备方法

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400145B (de) * 1990-06-08 1995-10-25 Ind Chimica Srl Verfahren zur herstellung von triazolyl-isopropanolen
ES2049663A1 (es) * 1992-10-13 1994-04-16 Genesis Para La Investigacion Procedimiento de obtencion de fluconazol.
WO2002076955A1 (en) * 2001-03-23 2002-10-03 Richter Gedeon Vegyeszéti Gyár Rt. Process for preparing fluconazole and its crystal modifications
US7094904B2 (en) 2001-03-23 2006-08-22 Richter Gedeon Vegyeszeti Gyar Rt. Process for preparing monohydrate and crystal modifications of fluconazole
BG66152B1 (bg) * 2001-03-23 2011-08-31 Richter Gedeon Vegyeszeti Gyar Rt. Метод за получаване на флуконазол и неговите кристални модификации
HRP20030854B1 (en) * 2001-03-23 2011-11-30 Richter Gedeon Vegyesz�ti Gy�r RT Process for preparing fluconazole and its crystal modifications
CN102344419A (zh) * 2011-09-16 2012-02-08 浙江金伯士药业有限公司 广谱抗真菌药氟康唑的制备方法

Also Published As

Publication number Publication date
ES549022A0 (es) 1986-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051207