ES8704895A1 - Un metodo para preparar 1-aminoalquilamino-4-ariloxipiperidinas sustituidas - Google Patents

Un metodo para preparar 1-aminoalquilamino-4-ariloxipiperidinas sustituidas

Info

Publication number
ES8704895A1
ES8704895A1 ES551426A ES551426A ES8704895A1 ES 8704895 A1 ES8704895 A1 ES 8704895A1 ES 551426 A ES551426 A ES 551426A ES 551426 A ES551426 A ES 551426A ES 8704895 A1 ES8704895 A1 ES 8704895A1
Authority
ES
Spain
Prior art keywords
aryloxypiperidines
aminoalkylamino
substituted
preparation
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551426A
Other languages
English (en)
Other versions
ES551426A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES551426A0 publication Critical patent/ES551426A0/es
Publication of ES8704895A1 publication Critical patent/ES8704895A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

METODO PARA LA PREPARACION DE 1-AMINOALQUILAMINO-4-ARILOXIPIPERIDINAS SUSTITUIDAS, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), EN LAS QUE X ES HIDROGENO O ALQUILO C1-C4, ACETILO O HALOGENO; N ES 1 O 2; Y R4 ES UN GRUPO BENCILO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (I), EN LA QUE R1 REPRESENTA DOS ATOMOS DE HIDROGENO; R2 REPRESENTA EL GRUPO BENCILO Y R3 ES UN GRUPO -OCH2CH2O-. A CONTINUACION SE PUEDE SOMETER, OPCIONALMENTE, EL COMPUESTO DE FORMULA GENERAL (I) OBTENIDO A UN PROCESO DE HIDROGENOLISIS. DE APLICACION COMO AGENTES ANALGESICOS.
ES551426A 1984-04-13 1986-01-30 Un metodo para preparar 1-aminoalquilamino-4-ariloxipiperidinas sustituidas Expired ES8704895A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/600,265 US4518713A (en) 1984-04-13 1984-04-13 Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines

Publications (2)

Publication Number Publication Date
ES551426A0 ES551426A0 (es) 1987-04-16
ES8704895A1 true ES8704895A1 (es) 1987-04-16

Family

ID=24402946

Family Applications (2)

Application Number Title Priority Date Filing Date
ES542146A Expired ES8608488A1 (es) 1984-04-13 1985-04-11 Un metodo para preparar nuevas 1-aminoalquil-amino-4-arilo- xipiperidinas sustituidas
ES551426A Expired ES8704895A1 (es) 1984-04-13 1986-01-30 Un metodo para preparar 1-aminoalquilamino-4-ariloxipiperidinas sustituidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542146A Expired ES8608488A1 (es) 1984-04-13 1985-04-11 Un metodo para preparar nuevas 1-aminoalquil-amino-4-arilo- xipiperidinas sustituidas

Country Status (7)

Country Link
US (1) US4518713A (es)
EP (1) EP0158283A3 (es)
JP (1) JPS60231653A (es)
DK (1) DK167785A (es)
ES (2) ES8608488A1 (es)
GR (1) GR850908B (es)
PT (1) PT80276B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192776A (en) * 1988-03-14 1993-03-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-subsituted-4-pentafluorophenoxypiperidines
EP0333028A1 (en) * 1988-03-14 1989-09-20 Hoechst-Roussel Pharmaceuticals Incorporated 1-Substituted 4-pentafluorophenoxypiperidines, a process for their preparation and their use as medicaments
US5212184A (en) * 1988-03-14 1993-05-18 Hoechst-Roussel Pharmaceuticals Inc. 1-substituted-4-pentafluorophenoxypiperidines
GB9321812D0 (en) * 1993-10-22 1993-12-15 Smithkline Beecham Plc Pharmaceuticals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542794A (en) * 1969-11-07 1970-11-24 Grover Cleveland Helsley 1-carbamoyl-4-phenoxypiperidines
US3743645A (en) * 1970-10-19 1973-07-03 Robins Co Inc A H 1-substituted-4-phenoxypiperidines
FR2154493B1 (es) * 1971-09-13 1975-10-31 Kali Chemie Ag
US4134982A (en) * 1977-09-26 1979-01-16 Warner-Lambert Company Antipsychotic 1-[4,4-Bis(4-fluorophenyl) butyl]-4-phenoxy-1,2,3,6-tetrahydropyridines
JPS5965056A (ja) * 1982-10-05 1984-04-13 Sumitomo Chem Co Ltd ペプチドアミド誘導体

Also Published As

Publication number Publication date
PT80276A (en) 1985-05-01
US4518713A (en) 1985-05-21
ES8608488A1 (es) 1986-06-16
EP0158283A2 (en) 1985-10-16
ES551426A0 (es) 1987-04-16
PT80276B (en) 1987-02-10
GR850908B (es) 1985-11-25
EP0158283A3 (en) 1989-01-04
JPS60231653A (ja) 1985-11-18
DK167785A (da) 1985-10-14
ES542146A0 (es) 1986-06-16
DK167785D0 (da) 1985-04-12

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