ES2033313T3 - Procedimiento de sintesis de azetidinonas. - Google Patents
Procedimiento de sintesis de azetidinonas.Info
- Publication number
- ES2033313T3 ES2033313T3 ES198787306402T ES87306402T ES2033313T3 ES 2033313 T3 ES2033313 T3 ES 2033313T3 ES 198787306402 T ES198787306402 T ES 198787306402T ES 87306402 T ES87306402 T ES 87306402T ES 2033313 T3 ES2033313 T3 ES 2033313T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- chem
- azetidinone
- synthesis procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCEDIMIENTO PARA OBTENER UN COMPUESTO QUE TIENE LA FORMULA (I) DONDE PR ES HIDROGENO O UN GRUPO HIDROXI PROTECTOR Y PR1 ES UN GRUPO PROTECTOR CARBOXI. DICHO PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UN COMPUETSO DE FORMULA 5, DONDE PR ES COMO SE HA DEFINIDO ANTES, CON UN COMPUESTO QUE TIENE LA FORMULA PR1-OH DONDE PR1 ES COMO SE HA DEFINIDO ANTES, Y O BIEN UN ACIDO MINERAL O BIEN UNA SAL DE PLATA DE UNA BASE ORGANICA Y HACIENDO RECCIONAR EL PRODUCTO ASI OBTENIDO CON UN COMPUESTO QUE TIENE LA FORMULA (II) DONDE L ES UN GRUPO RESIDUAL. SE PRESENTAN TRES ESQUEMAS DE REACCION ASI COMO NUEVOS COMPUESTOS INTERMEDIOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/887,394 US4767853A (en) | 1986-07-21 | 1986-07-21 | Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2033313T3 true ES2033313T3 (es) | 1993-03-16 |
Family
ID=25391044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787306402T Expired - Lifetime ES2033313T3 (es) | 1986-07-21 | 1987-07-20 | Procedimiento de sintesis de azetidinonas. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4767853A (es) |
EP (1) | EP0255278B1 (es) |
JP (1) | JPS6333360A (es) |
AT (1) | ATE73456T1 (es) |
CA (1) | CA1299172C (es) |
DE (1) | DE3777274D1 (es) |
ES (1) | ES2033313T3 (es) |
GR (1) | GR3004216T3 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4119856A1 (de) * | 1991-06-17 | 1992-12-24 | Hoechst Ag | N-acyl-s-(2-hydroxyalkyl)-cysteine, deren herstellung sowie deren verwendung als zwischenprodukte zur herstellung von synthetischen immunadjuvantien und synthetischen impfstoffen |
GB0124574D0 (en) | 2001-10-12 | 2001-12-05 | Biogemma Uk Ltd | Oil biosynthesis |
EP2723857B1 (en) | 2011-06-23 | 2019-03-27 | RHO Renewables, Inc. | Recombinant production systems for aromatic molecules |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3311638A (en) * | 1961-08-16 | 1967-03-28 | Bristol Myers Co | Anhydropenicillins |
US3948927A (en) * | 1972-04-10 | 1976-04-06 | Queen's University | 2,2-Dimethyl-3R-carboxy-6S-amino-1-oxa-4-aza-5R-bicyclo-[3,2,0]heptan-7-one |
US4347183A (en) * | 1981-02-02 | 1982-08-31 | Schering Corporation | Process for the synthesis of penems and carbapenems |
US4411906A (en) * | 1981-11-25 | 1983-10-25 | Schering Corporation | (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates |
US4443373A (en) * | 1982-03-30 | 1984-04-17 | Schering Corporation | Process for the production of antibiotic penems |
ATE112778T1 (de) * | 1982-11-29 | 1994-10-15 | Schering Corp | Verfahren zur herstellung von penem-verbindungen. |
US4530793A (en) * | 1982-11-29 | 1985-07-23 | Schering Corporation | Processes for the production of penems |
EP0115308A3 (en) * | 1983-01-25 | 1984-10-10 | Merck & Co. Inc. | 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids and process for preparing substituted 2-thioxopenams and 2-substituted thiopenems |
US4584133A (en) * | 1983-11-07 | 1986-04-22 | Schering Corporation | Process for the production of penems |
US4559333A (en) * | 1984-03-01 | 1985-12-17 | Schering Corporation | Hydrazone substituted penems |
US4596677A (en) * | 1984-04-06 | 1986-06-24 | Bristol-Myers Company | Anhydropenicillin intermediates |
-
1986
- 1986-07-21 US US06/887,394 patent/US4767853A/en not_active Expired - Fee Related
-
1987
- 1987-07-20 CA CA000542505A patent/CA1299172C/en not_active Expired - Fee Related
- 1987-07-20 ES ES198787306402T patent/ES2033313T3/es not_active Expired - Lifetime
- 1987-07-20 AT AT87306402T patent/ATE73456T1/de not_active IP Right Cessation
- 1987-07-20 EP EP87306402A patent/EP0255278B1/en not_active Expired - Lifetime
- 1987-07-20 DE DE8787306402T patent/DE3777274D1/de not_active Expired - Fee Related
- 1987-07-21 JP JP62182092A patent/JPS6333360A/ja active Pending
-
1992
- 1992-04-01 GR GR920400586T patent/GR3004216T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA1299172C (en) | 1992-04-21 |
JPS6333360A (ja) | 1988-02-13 |
ATE73456T1 (de) | 1992-03-15 |
EP0255278A1 (en) | 1988-02-03 |
GR3004216T3 (es) | 1993-03-31 |
US4767853A (en) | 1988-08-30 |
EP0255278B1 (en) | 1992-03-11 |
DE3777274D1 (de) | 1992-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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