ES8601917A1 - Procedimiento para producir 4,5-dihidro-6-vinil-3(2h)-piri- dazinonas y 6-vinil-3(2h)-piridazinonas - Google Patents

Procedimiento para producir 4,5-dihidro-6-vinil-3(2h)-piri- dazinonas y 6-vinil-3(2h)-piridazinonas

Info

Publication number
ES8601917A1
ES8601917A1 ES539673A ES539673A ES8601917A1 ES 8601917 A1 ES8601917 A1 ES 8601917A1 ES 539673 A ES539673 A ES 539673A ES 539673 A ES539673 A ES 539673A ES 8601917 A1 ES8601917 A1 ES 8601917A1
Authority
ES
Spain
Prior art keywords
pyridazinones
vinyl
dihydro
producing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539673A
Other languages
English (en)
Other versions
ES539673A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Natterman und Cie GmbH
Original Assignee
A Natterman und Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Natterman und Cie GmbH filed Critical A Natterman und Cie GmbH
Publication of ES539673A0 publication Critical patent/ES539673A0/es
Publication of ES8601917A1 publication Critical patent/ES8601917A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR 4,5-DIHIDRO-6-VINIL-3(2H)-PIRIDAZINONAS Y 6-VINIL-3 62H)-PIRIDAZINONAS SUSTITUIDAS. CONSISTE EN HACER REACCIONAR UN ACIDO 4-OXO-5-HEXENOICO DE FORMULA (II) O SUS ESTERES ALQUILICOS CON UN COMPUESTO DE HIDRAZINA DE FORMULA (III), EN DIOXANO O DIMETILFORMAMIDA O SUS MEZCLAS, CON AGUA Y/O ALCOHOL, A UNA TEMPERATURA DE 30 A 150 C, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES. SIENDO: A, UN MIEMBRO DEL GRUPO DE FORMULAS (IV) Y (V); R1, R2 Y R3, INDEPENDIENTEMENTE H O UN GRUPO METILO; R4, H O UN GRUPO METILO, Y..., UN ENLACE SENCILLO ENTRE DOS CARBUROS. SE UTILIZA EN EL TRATAMIENTO DE LA TENSION ALTA Y/O DE LA TROMBOSIS, Y EN LA PREVENCION DE TALES ESTADOS, EN SERES HUMANOS.
ES539673A 1984-01-20 1985-01-18 Procedimiento para producir 4,5-dihidro-6-vinil-3(2h)-piri- dazinonas y 6-vinil-3(2h)-piridazinonas Expired ES8601917A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843401911 DE3401911A1 (de) 1984-01-20 1984-01-20 Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES539673A0 ES539673A0 (es) 1985-11-16
ES8601917A1 true ES8601917A1 (es) 1985-11-16

Family

ID=6225471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES539673A Expired ES8601917A1 (es) 1984-01-20 1985-01-18 Procedimiento para producir 4,5-dihidro-6-vinil-3(2h)-piri- dazinonas y 6-vinil-3(2h)-piridazinonas

Country Status (9)

Country Link
EP (1) EP0150463A1 (es)
JP (1) JPS60161982A (es)
DE (1) DE3401911A1 (es)
DK (1) DK25385A (es)
ES (1) ES8601917A1 (es)
GR (1) GR850101B (es)
PH (1) PH20407A (es)
PT (1) PT79847B (es)
ZA (1) ZA85443B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599332A (en) * 1983-12-07 1986-07-08 Warner-Lambert Company 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
AU751139B2 (en) 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130252A1 (de) * 1981-07-31 1983-02-17 A. Nattermann & Cie GmbH, 5000 Köln 6-(5-((omega)-(1-imidazolyl)-alkyl)-thien-2-yl)-3-oxo-2,3,4,5-tetrahydro-pyridazine und deren saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3130251A1 (de) * 1981-07-31 1983-02-17 A. Nattermann & Cie GmbH, 5000 Köln 6-(4-((omega)-(1-imidazolyl)-alkyl)-phenyl)-3-oxo -2,3,4,5-tetrahydro-pyridazine und deren saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones
DE3209159A1 (de) 1982-03-13 1983-09-15 Basf Ag, 6700 Ludwigshafen Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung

Also Published As

Publication number Publication date
PT79847A (en) 1985-02-01
ES539673A0 (es) 1985-11-16
DE3401911A1 (de) 1985-08-01
DK25385A (da) 1985-07-21
PH20407A (en) 1987-01-05
ZA85443B (en) 1985-09-25
GR850101B (es) 1985-04-11
EP0150463A1 (en) 1985-08-07
DK25385D0 (da) 1985-01-18
PT79847B (en) 1986-10-23
JPS60161982A (ja) 1985-08-23

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