ES8102555A1 - Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico - Google Patents

Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico

Info

Publication number
ES8102555A1
ES8102555A1 ES489612A ES489612A ES8102555A1 ES 8102555 A1 ES8102555 A1 ES 8102555A1 ES 489612 A ES489612 A ES 489612A ES 489612 A ES489612 A ES 489612A ES 8102555 A1 ES8102555 A1 ES 8102555A1
Authority
ES
Spain
Prior art keywords
preparation
carbazoles
chloro
intermediates therefor
methylcarbazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489612A
Other languages
English (en)
Other versions
ES489612A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES489612A0 publication Critical patent/ES489612A0/es
Publication of ES8102555A1 publication Critical patent/ES8102555A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ACIDO 6-CLORO-ALFA-METILCARBAZOL-2-ACETICO. CARACTERIZADO PORQUE COMPRENDE SOMETER A HIDROGENOLISIS EL COMPUESTO DE FORMULA (I), Y RECUPERACION DEL PRODUCTO DE FORMULA (II), PARA LA HIDROGENOLISIS SE UTILIZA ALCANOICO INNICO, QUE PUEDE SER UN ACIDO ALCANOICO INFERIOR, O TAMBIEN UN ACIDO INORGANICO, TAL COMO EL ACIDO CLORHIDRICO, Y, POR ULTIMO SE PUEDE CREAR PARA ESTE PROCESO CLORURO ESTANOSO. ESTE PROCESO TIENE APLICACION ANTIINFLAMATORIA. *FORMULA*
ES489612A 1978-06-26 1980-03-15 Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico Expired ES8102555A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/919,010 US4150031A (en) 1978-06-26 1978-06-26 Hydroxy methyl carbazole acetic acid and esters

Publications (2)

Publication Number Publication Date
ES489612A0 ES489612A0 (es) 1981-02-16
ES8102555A1 true ES8102555A1 (es) 1981-02-16

Family

ID=25441338

Family Applications (2)

Application Number Title Priority Date Filing Date
ES481882A Expired ES481882A1 (es) 1978-06-26 1979-06-25 Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico.
ES489612A Expired ES8102555A1 (es) 1978-06-26 1980-03-15 Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES481882A Expired ES481882A1 (es) 1978-06-26 1979-06-25 Un procedimiento para la preparacion de acido 6-cloro-alfa- metilcarbazol-2-acetico.

Country Status (13)

Country Link
US (1) US4150031A (es)
EP (1) EP0006606B1 (es)
JP (2) JPS6040421B2 (es)
AT (1) ATE2144T1 (es)
CA (1) CA1107745A (es)
DK (1) DK247279A (es)
ES (2) ES481882A1 (es)
FI (1) FI792007A (es)
GR (1) GR72469B (es)
HU (1) HU178581B (es)
NO (1) NO149353C (es)
PT (1) PT69814A (es)
YU (1) YU149079A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK12785A (da) * 1984-02-07 1985-08-08 Hoffmann La Roche Fremgangsmaade til fremstilling af carbazolderivater
JPH0451260Y2 (es) * 1987-07-13 1992-12-02
JPH0413006U (es) * 1990-05-16 1992-02-03
US6268526B1 (en) 1998-12-16 2001-07-31 Albemarle Corporation Palladium catalyzed carbonylation process utilizing aromatic substituted alcohols and/or aromatic substituted alkyl halides
US9611217B2 (en) 2015-05-06 2017-04-04 Chemwerth, Inc. Synthetic processes of carprofen
CN106187860A (zh) * 2016-05-13 2016-12-07 凯默斯股份有限公司 卡洛芬的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205331A1 (es) * 1972-07-24 1976-04-30 Hoffmann La Roche Procedimiento para la preparacion de carbazoles
US3896145A (en) * 1972-07-24 1975-07-22 Hoffmann La Roche Carbazoles
US4057640A (en) * 1973-07-18 1977-11-08 Schering Aktiengesellschaft 5,6,7,8:Tetrahydrocarbazole-1-carboxylic acid derivatives

Also Published As

Publication number Publication date
ES481882A1 (es) 1980-06-16
EP0006606A1 (en) 1980-01-09
NO792126L (no) 1979-12-28
ATE2144T1 (de) 1983-01-15
GR72469B (es) 1983-11-10
JPS6034946A (ja) 1985-02-22
YU149079A (en) 1983-10-31
NO149353C (no) 1984-04-04
FI792007A (fi) 1979-12-27
HU178581B (en) 1982-05-28
NO149353B (no) 1983-12-27
ES489612A0 (es) 1981-02-16
JPS5522667A (en) 1980-02-18
PT69814A (en) 1979-07-01
JPS6040421B2 (ja) 1985-09-11
US4150031A (en) 1979-04-17
EP0006606B1 (en) 1982-12-29
CA1107745A (en) 1981-08-25
DK247279A (da) 1979-12-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102