DE69810800T2 - Azetidinonderivate zur behandlung von hcmv entzündungen - Google Patents
Azetidinonderivate zur behandlung von hcmv entzündungenInfo
- Publication number
- DE69810800T2 DE69810800T2 DE69810800T DE69810800T DE69810800T2 DE 69810800 T2 DE69810800 T2 DE 69810800T2 DE 69810800 T DE69810800 T DE 69810800T DE 69810800 T DE69810800 T DE 69810800T DE 69810800 T2 DE69810800 T2 DE 69810800T2
- Authority
- DE
- Germany
- Prior art keywords
- lower alkyl
- phenyl
- het
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical class C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- -1 methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6154897P | 1997-10-07 | 1997-10-07 | |
| PCT/CA1998/000954 WO1999018073A1 (en) | 1997-10-07 | 1998-10-06 | Azetidinone derivatives for the treatment of hcmv infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69810800D1 DE69810800D1 (de) | 2003-02-20 |
| DE69810800T2 true DE69810800T2 (de) | 2003-09-18 |
Family
ID=22036473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69810800T Expired - Lifetime DE69810800T2 (de) | 1997-10-07 | 1998-10-06 | Azetidinonderivate zur behandlung von hcmv entzündungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6211170B1 (de) |
| EP (1) | EP1023265B1 (de) |
| JP (1) | JP2001519330A (de) |
| AT (1) | ATE231124T1 (de) |
| AU (1) | AU9426198A (de) |
| CA (1) | CA2301967C (de) |
| DE (1) | DE69810800T2 (de) |
| DK (1) | DK1023265T3 (de) |
| ES (1) | ES2187064T3 (de) |
| WO (1) | WO1999018073A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200701232B (en) | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
| GB0608899D0 (en) * | 2006-05-05 | 2006-06-14 | Leuven K U Res & Dev | Novel viral replication inhibitors |
| WO2009045382A1 (en) * | 2007-10-04 | 2009-04-09 | Merck & Co., Inc. | Substituted aryl sulfone derivatives as calcium channel blockers |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| KR20120034644A (ko) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
| CA2760837C (en) * | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
| CN102638982B (zh) | 2009-05-12 | 2015-07-08 | 百时美施贵宝公司 | (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途 |
| US9216180B2 (en) | 2012-10-02 | 2015-12-22 | New York University | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay |
| AU2019339777B2 (en) | 2018-09-12 | 2022-09-01 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| TW202126649A (zh) | 2019-09-26 | 2021-07-16 | 瑞士商諾華公司 | 抗病毒吡唑并吡啶酮化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US4680391A (en) | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| NZ228600A (en) * | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
| DE377549T1 (de) | 1989-01-03 | 1990-11-08 | Marcos Y. Southbridge Mass. Us Kleinerman | Fernmessung physikalischer variablen mit faseroptischen systemen. |
| US5104862A (en) * | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5100880A (en) * | 1991-03-20 | 1992-03-31 | Merck & Co., Inc. | Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| GB2266527A (en) | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted azetidinones useful in the treatment of leukemia |
| GB9314350D0 (en) * | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
| RO113431B1 (ro) * | 1994-03-23 | 1998-07-30 | Tokyo Tanabe Co | Metoda pentru tratamentul maladiilor virale ale tractului respirator |
-
1998
- 1998-10-06 EP EP98947257A patent/EP1023265B1/de not_active Expired - Lifetime
- 1998-10-06 ES ES98947257T patent/ES2187064T3/es not_active Expired - Lifetime
- 1998-10-06 DK DK98947257T patent/DK1023265T3/da active
- 1998-10-06 AT AT98947257T patent/ATE231124T1/de active
- 1998-10-06 DE DE69810800T patent/DE69810800T2/de not_active Expired - Lifetime
- 1998-10-06 AU AU94261/98A patent/AU9426198A/en not_active Abandoned
- 1998-10-06 US US09/167,141 patent/US6211170B1/en not_active Expired - Lifetime
- 1998-10-06 WO PCT/CA1998/000954 patent/WO1999018073A1/en active IP Right Grant
- 1998-10-06 CA CA002301967A patent/CA2301967C/en not_active Expired - Fee Related
- 1998-10-06 JP JP2000514885A patent/JP2001519330A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69810800D1 (de) | 2003-02-20 |
| CA2301967A1 (en) | 1999-04-15 |
| ATE231124T1 (de) | 2003-02-15 |
| EP1023265B1 (de) | 2003-01-15 |
| AU9426198A (en) | 1999-04-27 |
| CA2301967C (en) | 2005-05-17 |
| EP1023265A1 (de) | 2000-08-02 |
| WO1999018073A1 (en) | 1999-04-15 |
| JP2001519330A (ja) | 2001-10-23 |
| US6211170B1 (en) | 2001-04-03 |
| ES2187064T3 (es) | 2003-05-16 |
| DK1023265T3 (da) | 2003-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |