ATE324113T1 - Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom - Google Patents
Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthomInfo
- Publication number
- ATE324113T1 ATE324113T1 AT04016883T AT04016883T ATE324113T1 AT E324113 T1 ATE324113 T1 AT E324113T1 AT 04016883 T AT04016883 T AT 04016883T AT 04016883 T AT04016883 T AT 04016883T AT E324113 T1 ATE324113 T1 AT E324113T1
- Authority
- AT
- Austria
- Prior art keywords
- xanthoma
- silyl
- dialkyl
- treatment
- phenol derivatives
- Prior art date
Links
- 206010048214 Xanthoma Diseases 0.000 title 1
- 206010048215 Xanthomatosis Diseases 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- -1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16528193A | 1993-12-10 | 1993-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE324113T1 true ATE324113T1 (de) | 2006-05-15 |
Family
ID=22598245
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04016883T ATE324113T1 (de) | 1993-12-10 | 1994-11-03 | Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom |
| AT95901141T ATE285238T1 (de) | 1993-12-10 | 1994-11-03 | Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl- phenol derivaten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95901141T ATE285238T1 (de) | 1993-12-10 | 1994-11-03 | Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl- phenol derivaten |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP1468693A3 (de) |
| JP (1) | JPH09511222A (de) |
| CN (1) | CN1092517C (de) |
| AT (2) | ATE324113T1 (de) |
| AU (1) | AU681731B2 (de) |
| CA (1) | CA2177968C (de) |
| DE (2) | DE69434720T2 (de) |
| DK (2) | DK1468692T3 (de) |
| ES (2) | ES2233937T3 (de) |
| HU (1) | HU220761B1 (de) |
| IL (1) | IL111905A (de) |
| NO (1) | NO311868B1 (de) |
| NZ (1) | NZ276285A (de) |
| PT (2) | PT732928E (de) |
| WO (1) | WO1995015760A1 (de) |
| ZA (1) | ZA949663B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| ATE356113T1 (de) | 1997-05-14 | 2007-03-15 | Atherogenics Inc | Probucolbernsteinsäureester zur hemmung der expression von vcam-1 |
| ES2190592T3 (es) * | 1997-06-24 | 2003-08-01 | Aventis Pharma Inc | Fenoles y tiofenoles alquil-4-sililheterociclicos como agentes antioxidantes. |
| US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
| AU7588498A (en) * | 1997-06-25 | 1999-01-04 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-{ (dimethyl-4-methoxyphenylsilyl) -methyloxy}phenol and 2,6-di-t-butyl-4-{ (dimethyl-2-methoxy-phenylsilyl) -methyloxy}phenol |
| AU8282798A (en) | 1997-07-01 | 1999-01-25 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| AU1911200A (en) * | 1998-11-09 | 2000-05-29 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| US6887712B1 (en) | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| US6821738B2 (en) | 1999-01-20 | 2004-11-23 | The Board Of Regents For Oklahoma State University | Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents |
| CA2428753C (en) | 2000-11-17 | 2013-05-21 | Universita Degli Studi Di Cagliari | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| IL162533A0 (en) | 2001-12-19 | 2005-11-20 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
| US6960683B2 (en) | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
| US7173129B2 (en) | 2003-06-06 | 2007-02-06 | Athero Genics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
| JP2007509054A (ja) * | 2003-10-17 | 2007-04-12 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 血管健康を促進するシリルフェノール |
| WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
| EP2139320A4 (de) | 2007-03-26 | 2010-09-08 | Salutria Pharmaceuticals Llc | Verfahren und zusammensetzungen von probucol-derivaten für die behandlung von diabetes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE349046B (de) * | 1966-12-23 | 1972-09-18 | C Guevne | |
| FR2230376A1 (en) * | 1973-05-24 | 1974-12-20 | Gueyne Jean | Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity |
| FR2308372A2 (fr) * | 1975-04-21 | 1976-11-19 | Cortial | Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif |
| US4670421A (en) * | 1982-07-12 | 1987-06-02 | American Cyanamid Company | Antiatherosclerotic silanes |
| US4900757A (en) * | 1988-12-08 | 1990-02-13 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
| US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
| NZ238807A (en) * | 1990-07-05 | 1994-03-25 | Merrell Dow Pharma | Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions |
-
1994
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 EP EP04016884A patent/EP1468693A3/de not_active Withdrawn
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en not_active Ceased
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 EP EP04016883A patent/EP1468692B1/de not_active Expired - Lifetime
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 EP EP95901141A patent/EP0732928B1/de not_active Expired - Lifetime
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
-
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1468692 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |