MX9606531A - Compuestos farmaceuticos. - Google Patents

Compuestos farmaceuticos.

Info

Publication number
MX9606531A
MX9606531A MX9606531A MX9606531A MX9606531A MX 9606531 A MX9606531 A MX 9606531A MX 9606531 A MX9606531 A MX 9606531A MX 9606531 A MX9606531 A MX 9606531A MX 9606531 A MX9606531 A MX 9606531A
Authority
MX
Mexico
Prior art keywords
alkyl
hydrogen
alkoxy
pharmaceutical compounds
coor
Prior art date
Application number
MX9606531A
Other languages
English (en)
Other versions
MXPA96006531A (es
Inventor
Peter Thaddeus Gallagher
William Martin Owton
Colin William Smith
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of MXPA96006531A publication Critical patent/MXPA96006531A/es
Publication of MX9606531A publication Critical patent/MX9606531A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Un compuesto farmacéutico de la formula (Ver Formula) en el cual R1 y R2 son cada uno hidrogeno, alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4átomos de carbono, HO-C1-4alquilo, C1-4alcoxi-C1-4alquilo, alquiltio de 1 a 4 átomos de carbono, halo, Ph, PhCR'R"= en donde Ph es fenilo opcionalmente substituido y R' y R" son cada uno hidrogeno o alquilo de 1 a 4 átomos de carbono, o R1 y R2 junto con el átomo de carbono, al cual están unidos forman un grupo cicloalquilo de 3 a 6 átomos de carbono, >C=0, >C=NOR' en donde R' es hidrogeno o alquilo de 1 a 4 átomos de carbono. R3, R4 y R5 son cada uno hidrogeno, halo, nitro, alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4 átomos de carbono, alquiltio de 1 a 4 átomos de carbono, C1-4-alquilo-CO-, C1-4alquilo-S(O)m- en donde m es 0, 1 o 2, R'R"N-SO2-, COOR', -CONR'R", -NR'R", -N(OR')COOR", -COR', NHSO2R', en donde R' y R" son cada uno hidrogeno o alquilo de 1 a 4 átomos de carbono, R6 y R7 son cada uno hidrogeno o alquilo de 1 a 4 átomos de carbono y n es 1 a 6, X es oxigeno o azufre, W es (Ver Formula) en donde p es 4 a 7, y q y r son cada uno 1 a 3, Y es >CO o -CH(OH)-, y Z es fenilo opcionalmente substituido o heteroarilo opcionalmente substituido; y sales y ésteres de los mismos.
MX9606531A 1995-12-19 1996-12-17 Compuestos farmaceuticos. MX9606531A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9525963.6 1995-12-19
GB9525963A GB2308362A (en) 1995-12-19 1995-12-19 Pharmaceutical indole derivatives

Publications (2)

Publication Number Publication Date
MXPA96006531A MXPA96006531A (es) 1997-06-01
MX9606531A true MX9606531A (es) 1997-06-28

Family

ID=10785702

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9606531A MX9606531A (es) 1995-12-19 1996-12-17 Compuestos farmaceuticos.

Country Status (27)

Country Link
US (1) US5773448A (es)
EP (1) EP0780388B1 (es)
JP (1) JPH09202784A (es)
KR (1) KR970042503A (es)
CN (1) CN1157822A (es)
AR (1) AR010205A1 (es)
AT (1) ATE204273T1 (es)
AU (1) AU720711B2 (es)
BR (1) BR9606066A (es)
CA (1) CA2193039C (es)
CZ (1) CZ372296A3 (es)
DE (1) DE69614491T2 (es)
DK (1) DK0780388T3 (es)
ES (1) ES2159693T3 (es)
GB (1) GB2308362A (es)
HU (1) HUP9603498A3 (es)
IL (1) IL119844A (es)
MX (1) MX9606531A (es)
NO (1) NO307512B1 (es)
NZ (1) NZ299959A (es)
PE (1) PE26198A1 (es)
PL (1) PL317526A1 (es)
PT (1) PT780388E (es)
SG (1) SG47206A1 (es)
TR (1) TR199601018A1 (es)
YU (1) YU67096A (es)
ZA (1) ZA9610589B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810886D0 (en) * 1998-05-13 1998-07-22 Lilly Industries Ltd Pharmaceutical compounds
GB2362826A (en) * 2000-06-02 2001-12-05 Lilly Co Eli A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
CN106928122A (zh) * 2017-03-07 2017-07-07 贵州大学 3‑烷氧基季碳氧化吲哚及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4035369A (en) * 1975-10-08 1977-07-12 Janssen Pharmaceutica N.V. 1-Benzazolylalkyl-4-substituted-piperidines
US4432978A (en) * 1979-07-30 1984-02-21 Pfizer Inc. Hexahydro-trans-pyridoindole
US4254127A (en) * 1980-04-03 1981-03-03 Janssen Pharmaceutica, N.V. 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
IL69132A (en) * 1982-07-14 1986-02-28 Roussel Uclaf Benzo-and naphtho-thiopyranopyrimidinones,their preparation and pharmaceutical compositions containing them
US4658038A (en) * 1982-10-07 1987-04-14 Research Foundation For Mental Hygiene, Inc. N-acylated 5-hydroxytryptophan amide derivatives
US4608374A (en) * 1983-11-07 1986-08-26 Hoechst-Roussel Pharmaceuticals Inc. 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
DE3563964D1 (en) * 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
US4789676A (en) * 1986-03-05 1988-12-06 Merrell Dow Pharmaceuticals Inc. Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents
FR2634207B1 (fr) * 1988-07-12 1990-09-07 Synthelabo Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique
EP0351283A1 (fr) * 1988-07-12 1990-01-17 Synthelabo Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique
FR2635524B1 (fr) * 1988-08-19 1992-04-24 Adir Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
TW203049B (es) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
FR2661177A1 (fr) * 1990-04-23 1991-10-25 Rhone Poulenc Sante Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant.
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
FR2679561A1 (fr) * 1991-07-26 1993-01-29 Schneider Marc Nouveaux derives de l'(indolyl-1) alkylamine substituee par une chaine presentant des groupements carbonyles conjugues a un noyau aromatique.
SE9103752D0 (sv) 1991-12-18 1991-12-18 Astra Ab New compounds
TW218875B (es) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use
EP0572235A3 (en) * 1992-05-28 1994-06-01 Tanabe Seiyaku Co Beta-carboline derivatives with anticholecystoquinine activity
WO1994011012A1 (en) * 1992-11-06 1994-05-26 Merck & Co., Inc. Substituted dipeptide analogs promote release of growth hormone
US5536716A (en) * 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
RU2168512C2 (ru) * 1992-12-11 2001-06-10 Мерк Энд Ко., Инк. Спиропиперидины, способы их получения (варианты)
IL112111A (en) * 1993-12-23 2000-07-16 Novo Nordisk As Peptides having growth hormone releasing properties and pharmaceutical compositions containing them
PL181280B1 (pl) * 1993-12-23 2001-07-31 Novo Nordisk As oraz zawierajaca je kompozycja farmaceutyczna PL PL PL PL PL PL PL PL
GB9418326D0 (en) * 1994-09-12 1994-11-02 Lilly Industries Ltd Pharmaceutical compounds
DE69531476T2 (de) * 1994-09-12 2004-06-09 Lilly Industries Ltd., Basingstoke Serotonergische Modulatoren
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Also Published As

Publication number Publication date
ATE204273T1 (de) 2001-09-15
DE69614491D1 (de) 2001-09-20
IL119844A (en) 2000-12-06
SG47206A1 (en) 1998-03-20
EP0780388B1 (en) 2001-08-16
US5773448A (en) 1998-06-30
NO965448D0 (no) 1996-12-18
ZA9610589B (en) 1998-01-16
NZ299959A (en) 1998-09-24
HU9603498D0 (en) 1997-02-28
PL317526A1 (en) 1997-06-23
NO307512B1 (no) 2000-04-17
KR970042503A (ko) 1997-07-24
EP0780388A1 (en) 1997-06-25
CZ372296A3 (en) 1997-08-13
AU720711B2 (en) 2000-06-08
BR9606066A (pt) 1998-09-01
NO965448L (no) 1997-06-20
GB2308362A (en) 1997-06-25
CA2193039C (en) 2006-04-04
IL119844A0 (en) 1997-03-18
HUP9603498A2 (hu) 1998-09-28
HUP9603498A3 (en) 2001-04-28
JPH09202784A (ja) 1997-08-05
AR010205A1 (es) 2000-06-07
GB9525963D0 (en) 1996-02-21
CA2193039A1 (en) 1997-06-20
ES2159693T3 (es) 2001-10-16
DE69614491T2 (de) 2002-04-18
CN1157822A (zh) 1997-08-27
PT780388E (pt) 2001-12-28
TR199601018A1 (tr) 1997-07-21
YU67096A (sh) 1999-03-04
DK0780388T3 (da) 2001-10-08
AU7546096A (en) 1997-06-26
PE26198A1 (es) 1998-05-27

Similar Documents

Publication Publication Date Title
AU537414B2 (en) Pyroglutamic acid derivatives
HUT72653A (en) N-acyl-sulfamic acid esters (or thioesters), n-acyl-sulfonamides and n-sulfonyl-carbamic-acid-esters (or thioesters) and pharmaceutical compositions of hypercholesterolemic activity containing them
HU9502512D0 (en) Anthranilic acid derivative
PH31631A (en) Serotonerbic tetrahydropyridoindoles.
ES8303395A1 (es) "procedimiento de preparar compuestos benzoxepinicos y analogos".
MX9606531A (es) Compuestos farmaceuticos.
ES2000544A6 (es) Un procedimiento para la preparacion de derivados hidroxibenciltioheterociclicos
BG102008A (en) Derivatives of hydroxymic acid
ATE231124T1 (de) Azetidinonderivate zur behandlung von hcmv entzündungen
GB9916374D0 (en) Chemical compounds
TW288013B (es)
BG102255A (en) Carbamoylcarboxy acid amides
ES8704918A1 (es) Un procedimiento para la preparacion de nuevos derivados de esteres fosforicos.
DE69428206D1 (de) Chinolincarbonsäurederivate und ihre salze
ES8306763A1 (es) Procedimiento para preparar fosfatos de oximas aciclicos y heterociclicos con actividad insecticida, acaricida y neumaticida.
PH31474A (en) N-aminoboalkyl-substituted nitrogen-containing five membered heterocyclic compounds.
ES8406489A1 (es) Procedimiento para la obtencion de derivados de pirano-pirazol
DE3664048D1 (en) Phosphoric acid derivatives, process for their preparation and their use for combatting pests
DE3665587D1 (en) Oximino phosphoric-acid derivatives, process for their preparation and their use as pesticides
TH29686B (th) สารประกอบทางเภสัช
ES8701144A1 (es) Un procedimiento para preparar un derivado de tetrahidronaf-taleno
MX9804482A (es) Quinolinas y quinazolinas utiles en terapias.
AU8292787A (en) Fluorine-containing macrolide compounds and their use