ES2159693T3 - Ligandos 5ht1dalfa y 5ht2a. - Google Patents
Ligandos 5ht1dalfa y 5ht2a.Info
- Publication number
- ES2159693T3 ES2159693T3 ES96309200T ES96309200T ES2159693T3 ES 2159693 T3 ES2159693 T3 ES 2159693T3 ES 96309200 T ES96309200 T ES 96309200T ES 96309200 T ES96309200 T ES 96309200T ES 2159693 T3 ES2159693 T3 ES 2159693T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- rent
- sup
- hydrogen
- alcoxi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 HALO Chemical class 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 101000806173 Sus scrofa Dehydrogenase/reductase SDR family member 4 Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Abstract
COMPUESTO FARMACEUTICO DE FORMULA EN DONDE R 1 Y R SUP,2} SON CADA UNO HIDROGENO, ALQUILO C{SUB,1-4}, ALCOXI C{SUB,1-4}, HO-ALQUILO C{SUB,1-4}, ALCOXI C{SUB,1-4}ALQUILO C{SUB,1-4}, ALQUILTIO C{SUB,1-4}, HALO O PHCR''R''''- DONDE PH ES FENILO OPCIONALMENTE SUSTITUIDO Y R'' Y R'''' SON CADA UNO HIDROGENO O ALQUILO C{SUB,1-4}, O R{SUP,1} Y R{SUP,2} JUNTO CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS, FORMAN UN GRUPO CICLOALQUILO C{SUB,3-6}, R{SUP,3}, R{SUP,4} Y R{SUP,5} SON CADA UNO HIDROGENO, HALO, NITRO, ALQUILO C{SUB,1-4}, ALCOXI C{SUB,1-4}, ALQUILTIO C{SUB,14}, ALQUIL C{SUB,1-4}-CO-, ALQUIL C{SUB,1-4}-S(O){SUB,M}- DONDE M ES 0,1 O 2, R''R''''N-SO{SUB,2}-, -COOR'', -CONR''R'''', -NR''R'''', N(OR'')COOR'''', -COR'', -NHSO{SUB,2}R'', DONDE R'' Y R'''' SON CADA UNO HIDROGENO, O ALQUILO C{SUB,1-4}, R{SUP,6} Y R{SUP,7} SON CADA UNO HIDROGENO O ALQUILO C{SUB,1-4}, Y N ES DE 1 A 6, X ES OXIGENO O AZUFRE, W ES DONDE P ES DE 4 A 7, Y Q Y R SON CADA UNO DE 1 A 3, Y ES Y Z ES FENILO OPCIONALMENTE SUSTITUIDO O HETEROARILO OPCIONALMENTE SUSTITUIDO; Y SALES Y ESTERES DE DICHOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9525963A GB2308362A (en) | 1995-12-19 | 1995-12-19 | Pharmaceutical indole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2159693T3 true ES2159693T3 (es) | 2001-10-16 |
Family
ID=10785702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96309200T Expired - Lifetime ES2159693T3 (es) | 1995-12-19 | 1996-12-17 | Ligandos 5ht1dalfa y 5ht2a. |
Country Status (27)
Country | Link |
---|---|
US (1) | US5773448A (es) |
EP (1) | EP0780388B1 (es) |
JP (1) | JPH09202784A (es) |
KR (1) | KR970042503A (es) |
CN (1) | CN1157822A (es) |
AR (1) | AR010205A1 (es) |
AT (1) | ATE204273T1 (es) |
AU (1) | AU720711B2 (es) |
BR (1) | BR9606066A (es) |
CA (1) | CA2193039C (es) |
CZ (1) | CZ372296A3 (es) |
DE (1) | DE69614491T2 (es) |
DK (1) | DK0780388T3 (es) |
ES (1) | ES2159693T3 (es) |
GB (1) | GB2308362A (es) |
HU (1) | HUP9603498A3 (es) |
IL (1) | IL119844A (es) |
MX (1) | MX9606531A (es) |
NO (1) | NO307512B1 (es) |
NZ (1) | NZ299959A (es) |
PE (1) | PE26198A1 (es) |
PL (1) | PL317526A1 (es) |
PT (1) | PT780388E (es) |
SG (1) | SG47206A1 (es) |
TR (1) | TR199601018A1 (es) |
YU (1) | YU67096A (es) |
ZA (1) | ZA9610589B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9810886D0 (en) * | 1998-05-13 | 1998-07-22 | Lilly Industries Ltd | Pharmaceutical compounds |
GB2362826A (en) * | 2000-06-02 | 2001-12-05 | Lilly Co Eli | A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
CN106928122A (zh) * | 2017-03-07 | 2017-07-07 | 贵州大学 | 3‑烷氧基季碳氧化吲哚及其制备方法 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4035369A (en) * | 1975-10-08 | 1977-07-12 | Janssen Pharmaceutica N.V. | 1-Benzazolylalkyl-4-substituted-piperidines |
US4432978A (en) * | 1979-07-30 | 1984-02-21 | Pfizer Inc. | Hexahydro-trans-pyridoindole |
US4254127A (en) * | 1980-04-03 | 1981-03-03 | Janssen Pharmaceutica, N.V. | 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives |
FR2523964B1 (fr) * | 1982-03-23 | 1985-09-27 | Sanofi Sa | Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation |
IL69132A (en) * | 1982-07-14 | 1986-02-28 | Roussel Uclaf | Benzo-and naphtho-thiopyranopyrimidinones,their preparation and pharmaceutical compositions containing them |
US4658038A (en) * | 1982-10-07 | 1987-04-14 | Research Foundation For Mental Hygiene, Inc. | N-acylated 5-hydroxytryptophan amide derivatives |
US4608374A (en) * | 1983-11-07 | 1986-08-26 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents |
GB8332704D0 (en) * | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
EP0181793B1 (fr) * | 1984-10-16 | 1988-07-27 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique |
US4789676A (en) * | 1986-03-05 | 1988-12-06 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives, usefull as anxiolytic agents |
EP0351283A1 (fr) * | 1988-07-12 | 1990-01-17 | Synthelabo | Dérivés de [(pipéridinyl-4) méthyl]-2 dihydro-2,3 1H-isoindole et tétrahydro-2,3,4,5 1H-benzazépines, leur préparation et leur application en thérapeutique |
FR2634207B1 (fr) * | 1988-07-12 | 1990-09-07 | Synthelabo | Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique |
FR2635524B1 (fr) * | 1988-08-19 | 1992-04-24 | Adir | Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US5068234A (en) * | 1990-02-26 | 1991-11-26 | Sterling Drug Inc. | 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles |
GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
TW203049B (es) * | 1990-04-13 | 1993-04-01 | Yamanouchi Pharma Co Ltd | |
FR2661177A1 (fr) * | 1990-04-23 | 1991-10-25 | Rhone Poulenc Sante | Derives du naphtosultame antagonistes de la serotonine, leur preparation et les medicaments les contenant. |
US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
FR2679561A1 (fr) * | 1991-07-26 | 1993-01-29 | Schneider Marc | Nouveaux derives de l'(indolyl-1) alkylamine substituee par une chaine presentant des groupements carbonyles conjugues a un noyau aromatique. |
SE9103752D0 (sv) | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
TW218875B (es) * | 1992-03-09 | 1994-01-11 | Takeda Pharm Industry Co Ltd | |
TW226019B (es) * | 1992-03-23 | 1994-07-01 | Sankyo Co | |
EP0572235A3 (en) * | 1992-05-28 | 1994-06-01 | Tanabe Seiyaku Co | Beta-carboline derivatives with anticholecystoquinine activity |
JPH08503213A (ja) * | 1992-11-06 | 1996-04-09 | メルク エンド カンパニー インコーポレーテッド | 成長ホルモンの放出を促進する置換ジペプチド同族体 |
PL176993B1 (pl) * | 1992-12-11 | 1999-08-31 | Merck & Co Inc | Nowe związki spiropiperydynowe oraz sposób ich wytwarzania |
US5578593A (en) * | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
WO1995017423A1 (en) * | 1993-12-23 | 1995-06-29 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
CN1052730C (zh) * | 1993-12-23 | 2000-05-24 | 诺沃挪第克公司 | 具有生长激素释放特性的化合物 |
GB9418326D0 (en) * | 1994-09-12 | 1994-11-02 | Lilly Industries Ltd | Pharmaceutical compounds |
ATE247114T1 (de) * | 1994-09-12 | 2003-08-15 | Lilly Co Eli | Serotonergische modulatoren |
US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
-
1995
- 1995-12-19 GB GB9525963A patent/GB2308362A/en not_active Withdrawn
-
1996
- 1996-12-16 CA CA002193039A patent/CA2193039C/en not_active Expired - Fee Related
- 1996-12-16 PE PE1996000916A patent/PE26198A1/es not_active Application Discontinuation
- 1996-12-17 NZ NZ299959A patent/NZ299959A/en unknown
- 1996-12-17 TR TR96/01018A patent/TR199601018A1/xx unknown
- 1996-12-17 MX MX9606531A patent/MX9606531A/es unknown
- 1996-12-17 IL IL11984496A patent/IL119844A/xx not_active IP Right Cessation
- 1996-12-17 ZA ZA9610589A patent/ZA9610589B/xx unknown
- 1996-12-17 YU YU67096A patent/YU67096A/sh unknown
- 1996-12-17 SG SG1996011771A patent/SG47206A1/en unknown
- 1996-12-17 DK DK96309200T patent/DK0780388T3/da active
- 1996-12-17 EP EP96309200A patent/EP0780388B1/en not_active Expired - Lifetime
- 1996-12-17 DE DE69614491T patent/DE69614491T2/de not_active Expired - Fee Related
- 1996-12-17 AT AT96309200T patent/ATE204273T1/de not_active IP Right Cessation
- 1996-12-17 PL PL96317526A patent/PL317526A1/xx unknown
- 1996-12-17 AR ARP960105722A patent/AR010205A1/es not_active Application Discontinuation
- 1996-12-17 ES ES96309200T patent/ES2159693T3/es not_active Expired - Lifetime
- 1996-12-17 PT PT96309200T patent/PT780388E/pt unknown
- 1996-12-18 JP JP8337819A patent/JPH09202784A/ja active Pending
- 1996-12-18 HU HU9603498A patent/HUP9603498A3/hu unknown
- 1996-12-18 BR BR9606066A patent/BR9606066A/pt not_active Application Discontinuation
- 1996-12-18 KR KR1019960067182A patent/KR970042503A/ko not_active Application Discontinuation
- 1996-12-18 CZ CZ963722A patent/CZ372296A3/cs unknown
- 1996-12-18 NO NO965448A patent/NO307512B1/no not_active IP Right Cessation
- 1996-12-18 CN CN96117941A patent/CN1157822A/zh active Pending
- 1996-12-19 AU AU75460/96A patent/AU720711B2/en not_active Ceased
-
1997
- 1997-04-14 US US08/833,239 patent/US5773448A/en not_active Expired - Fee Related
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