ATE218141T1 - Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number
ATE218141T1
ATE218141T1 AT96402821T AT96402821T ATE218141T1 AT E218141 T1 ATE218141 T1 AT E218141T1 AT 96402821 T AT96402821 T AT 96402821T AT 96402821 T AT96402821 T AT 96402821T AT E218141 T1 ATE218141 T1 AT E218141T1
Authority
AT
Austria
Prior art keywords
group
aryl
alkyl
carbon atoms
heterocyclic
Prior art date
Application number
AT96402821T
Other languages
English (en)
Inventor
Constantin Agouridas
Francois Bretin
Jean-Francois Chantot
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE218141T1 publication Critical patent/ATE218141T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT96402821T 1995-12-22 1996-12-19 Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel ATE218141T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515322A FR2742757B1 (fr) 1995-12-22 1995-12-22 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ATE218141T1 true ATE218141T1 (de) 2002-06-15

Family

ID=9485837

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96402821T ATE218141T1 (de) 1995-12-22 1996-12-19 Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (9)

Country Link
US (1) US5747467A (de)
EP (1) EP0799833B1 (de)
JP (1) JP3140703B2 (de)
AT (1) ATE218141T1 (de)
DE (1) DE69621421T2 (de)
DK (1) DK0799833T3 (de)
ES (1) ES2176419T3 (de)
FR (1) FR2742757B1 (de)
PT (1) PT799833E (de)

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CO4990960A1 (es) * 1997-10-29 2000-12-26 Abbott Lab Derivados de cetolidos 2-halo-6-o sustituidos
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
FR2777282B1 (fr) * 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
AU5299499A (en) 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2784682B1 (fr) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
USRE39743E1 (en) * 1998-10-15 2007-07-24 Aventis Pharma S.A. 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use
FR2785612A1 (fr) 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
ES2273964T3 (es) 1998-12-10 2007-05-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
AP2001002222A0 (en) * 1999-01-27 2001-09-30 Pfizer Prod Inc Ketolide antibiotics.
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6395710B1 (en) 1999-04-16 2002-05-28 Kosan Biosciences, Inc. Macrolide antiinfective agents
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
JP2001261694A (ja) * 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
TR200401847T4 (tr) 2000-06-30 2004-09-21 Pfizer Products Inc. Makrolit antibiyotikler.
ES2275621T3 (es) * 2000-12-21 2007-06-16 Glaxo Group Limited Antibioticos macrolidos.
EP1551865B1 (de) * 2002-07-08 2009-04-22 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
AU2003255851B2 (en) * 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
US6727229B2 (en) * 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
AR043050A1 (es) * 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
BRPI0408117A (pt) * 2003-03-05 2006-03-01 Rib X Pharmaceuticals Inc compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos
EP1638549A4 (de) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc Neue antibakterielle mittel
WO2005007143A2 (en) * 2003-07-14 2005-01-27 The Board Of Trustees Of The University Of Illinois Use of makrolides and ketolides for the treatment of tuberculosis
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
EP2716647A3 (de) * 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Makrocyclische Verbindungen Und Verfahren Zu Deren Herstellung Und Anwendung
RU2397987C2 (ru) * 2004-07-28 2010-08-27 Рэнбакси Лабораториз Лимитед Кетолидные производные в качестве антибактериальных агентов
US20090170790A1 (en) * 2004-10-25 2009-07-02 Biswajit Das Ketolide derivatives as antibacterial agents
EP2233493A1 (de) 2004-12-21 2010-09-29 Pfizer Products Inc. Makrolide
EP1957508A2 (de) * 2005-11-23 2008-08-20 Ranbaxy Laboratories Limited Ketolid-derivate als antibakterielle agentien
EP1960413A2 (de) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Makrolidderivate als antibakterielle mittel
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) * 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
WO2025228440A1 (zh) * 2024-04-30 2025-11-06 苏州信诺维医药科技股份有限公司 大环内酯类化合物、其制备方法及其用途

Family Cites Families (9)

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FR487411A (fr) * 1916-03-06 1918-07-03 Henri Dreyfus Procédé pour la fabrication de l'aldéhyde acétique en partant de l'acétylène
FR596802A (fr) * 1924-07-28 1925-11-02 Ste Chim Usines Rhone Procédé pour rendre la cellulose facilement éthérifiable
FR676409A (fr) * 1929-06-08 1930-02-22 Moule multiple
FR680967A (fr) * 1929-08-29 1930-05-08 Perfectionnements à la construction des appareils broyeurs
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
SE9401213L (sv) * 1994-04-11 1995-04-03 Valeo Engine Cooling Ab Värmeväxlare placerad i en ränna i en värmeväxlartank
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
US5747467A (en) 1998-05-05
EP0799833B1 (de) 2002-05-29
ES2176419T3 (es) 2002-12-01
DK0799833T3 (da) 2002-09-09
DE69621421D1 (de) 2002-07-04
EP0799833A1 (de) 1997-10-08
PT799833E (pt) 2002-10-31
FR2742757B1 (fr) 1998-01-30
DE69621421T2 (de) 2003-01-09
FR2742757A1 (fr) 1997-06-27
JP3140703B2 (ja) 2001-03-05
JPH09176182A (ja) 1997-07-08

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Legal Events

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UEP Publication of translation of european patent specification