DE69621421D1 - Erythromycin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel - Google Patents
Erythromycin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als ArzneimittelInfo
- Publication number
- DE69621421D1 DE69621421D1 DE69621421T DE69621421T DE69621421D1 DE 69621421 D1 DE69621421 D1 DE 69621421D1 DE 69621421 T DE69621421 T DE 69621421T DE 69621421 T DE69621421 T DE 69621421T DE 69621421 D1 DE69621421 D1 DE 69621421D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- aryl
- alkyl
- carbon atoms
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9515322A FR2742757B1 (fr) | 1995-12-22 | 1995-12-22 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69621421D1 true DE69621421D1 (de) | 2002-07-04 |
DE69621421T2 DE69621421T2 (de) | 2003-01-09 |
Family
ID=9485837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69621421T Expired - Lifetime DE69621421T2 (de) | 1995-12-22 | 1996-12-19 | Erythromycin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Country Status (9)
Country | Link |
---|---|
US (1) | US5747467A (de) |
EP (1) | EP0799833B1 (de) |
JP (1) | JP3140703B2 (de) |
AT (1) | ATE218141T1 (de) |
DE (1) | DE69621421T2 (de) |
DK (1) | DK0799833T3 (de) |
ES (1) | ES2176419T3 (de) |
FR (1) | FR2742757B1 (de) |
PT (1) | PT799833E (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
CO4990960A1 (es) * | 1997-10-29 | 2000-12-26 | Abbott Lab | Derivados de cetolidos 2-halo-6-o sustituidos |
US6124269A (en) * | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
FR2771008B1 (fr) * | 1997-11-17 | 2000-04-28 | Hoechst Marion Roussel Inc | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
JP4573925B2 (ja) * | 1998-07-09 | 2010-11-04 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用 |
FR2792637B1 (fr) * | 1999-04-26 | 2001-06-01 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2781484B1 (fr) * | 1998-07-21 | 2001-08-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments |
EP1115732B1 (de) * | 1998-09-22 | 2005-06-29 | Pfizer Products Inc. | Carbamat- und carbazatketolidantibiotika |
USRE39743E1 (en) * | 1998-10-15 | 2007-07-24 | Aventis Pharma S.A. | 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use |
FR2784682B1 (fr) * | 1998-10-15 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments |
FR2785612A1 (fr) | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
ES2273964T3 (es) | 1998-12-10 | 2007-05-16 | Pfizer Products Inc. | Antibioticos de carbamato y carbazato cetolida. |
ID30233A (id) * | 1999-01-27 | 2001-11-15 | Pfizer Prod Inc | Antibiotika ketolida |
FR2789392B1 (fr) * | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
US6939861B2 (en) * | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
AU775637B2 (en) | 1999-04-16 | 2004-08-12 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
MXPA01010521A (es) | 1999-04-16 | 2003-08-19 | Johnson & Johnson | Antibacteriales de cetolidos. |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6355620B1 (en) | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
PL352720A1 (en) * | 1999-05-24 | 2003-09-08 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
JP2001261694A (ja) * | 2000-03-06 | 2001-09-26 | Pfizer Prod Inc | ケトライド抗生物質 |
DE60104240T2 (de) | 2000-06-30 | 2005-08-04 | Pfizer Products Inc., Groton | Makrolid-Antibiotika |
CA2432429A1 (en) * | 2000-12-21 | 2002-06-27 | Glaxo Group Limited | Macrolide antibiotics |
WO2004005313A2 (en) * | 2002-07-08 | 2004-01-15 | Pliva - Istrazivacki Institut D.O.O. | Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules |
US7091187B2 (en) * | 2002-07-08 | 2006-08-15 | Pliva-Istrazivacki Institut D.O.O. | Compounds, compositions and methods for treatment of inflammatory diseases and conditions |
US6727229B2 (en) * | 2002-08-19 | 2004-04-27 | Enanta Pharmaceuticals, Inc. | 11,12-substituted lactone ketolide derivatives having antibacterial activity |
TW200420573A (en) * | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
KR20060002800A (ko) * | 2003-03-05 | 2006-01-09 | 립-엑스 파마슈티칼즈, 인크. | 이관능성 헤테로시클릭 화합물, 및 그의 제조 및 사용 방법 |
WO2004080391A2 (en) | 2003-03-10 | 2004-09-23 | Optimer Pharmaceuticals, Inc. | Novel antibacterial agents |
US20050014706A1 (en) * | 2003-07-14 | 2005-01-20 | Kanakeshwari Falzari | Method of treating tuberculosis |
JP2007509980A (ja) * | 2003-10-30 | 2007-04-19 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法 |
JP2007512256A (ja) * | 2003-11-18 | 2007-05-17 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法 |
CN102816194A (zh) * | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
US20080287376A1 (en) * | 2004-07-28 | 2008-11-20 | Mohammad Salman | Ketolide Derivatives as Antibacterial Agents |
WO2006046112A2 (en) * | 2004-10-25 | 2006-05-04 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
PL1836211T3 (pl) * | 2004-12-21 | 2010-07-30 | Pfizer Prod Inc | Makrolidy |
EP1960413A2 (de) * | 2005-11-23 | 2008-08-27 | Ranbaxy Laboratories Limited | Makrolidderivate als antibakterielle mittel |
US20090005325A1 (en) * | 2005-11-23 | 2009-01-01 | Biswajit Bas | Ketolide Derivatives as Antibacterial Agents |
US9453042B2 (en) | 2007-10-25 | 2016-09-27 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
WO2010048600A1 (en) * | 2008-10-24 | 2010-04-29 | Cempra Pharmaceuticals, Inc. | Methods for treating resistant diseases using triazole containing macrolides |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
WO2011032052A1 (en) | 2009-09-10 | 2011-03-17 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and mac diseases |
DK2550286T3 (en) | 2010-03-22 | 2016-02-29 | Cempra Pharmaceuticals Inc | CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF |
EP2571506B1 (de) | 2010-05-20 | 2017-05-10 | Cempra Pharmaceuticals, Inc. | Verfahren zur herstellung von makroliden und ketoliden sowie zwischenprodukte dafür |
WO2012034058A1 (en) | 2010-09-10 | 2012-03-15 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
RU2658050C2 (ru) | 2012-03-27 | 2018-06-19 | Семпра Фармасьютикалз, Инк. | Парентеральные составы для введения макролидных антибиотиков |
AU2014239959A1 (en) | 2013-03-14 | 2015-10-01 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
US9751908B2 (en) | 2013-03-15 | 2017-09-05 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR487411A (fr) * | 1916-03-06 | 1918-07-03 | Henri Dreyfus | Procédé pour la fabrication de l'aldéhyde acétique en partant de l'acétylène |
FR596802A (fr) * | 1924-07-28 | 1925-11-02 | Ste Chim Usines Rhone | Procédé pour rendre la cellulose facilement éthérifiable |
FR676409A (fr) * | 1929-06-08 | 1930-02-22 | Moule multiple | |
FR680967A (fr) * | 1929-08-29 | 1930-05-08 | Perfectionnements à la construction des appareils broyeurs | |
IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
SE501629C2 (sv) * | 1994-04-11 | 1995-04-03 | Valeo Engine Cooling Ab | Värmeväxlare placerad i en ränna i en värmeväxlartank |
FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
-
1995
- 1995-12-22 FR FR9515322A patent/FR2742757B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-19 DE DE69621421T patent/DE69621421T2/de not_active Expired - Lifetime
- 1996-12-19 PT PT96402821T patent/PT799833E/pt unknown
- 1996-12-19 EP EP96402821A patent/EP0799833B1/de not_active Expired - Lifetime
- 1996-12-19 AT AT96402821T patent/ATE218141T1/de active
- 1996-12-19 US US08/767,954 patent/US5747467A/en not_active Expired - Lifetime
- 1996-12-19 DK DK96402821T patent/DK0799833T3/da active
- 1996-12-19 ES ES96402821T patent/ES2176419T3/es not_active Expired - Lifetime
- 1996-12-20 JP JP08354633A patent/JP3140703B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3140703B2 (ja) | 2001-03-05 |
JPH09176182A (ja) | 1997-07-08 |
FR2742757B1 (fr) | 1998-01-30 |
PT799833E (pt) | 2002-10-31 |
EP0799833B1 (de) | 2002-05-29 |
US5747467A (en) | 1998-05-05 |
EP0799833A1 (de) | 1997-10-08 |
FR2742757A1 (fr) | 1997-06-27 |
ES2176419T3 (es) | 2002-12-01 |
DK0799833T3 (da) | 2002-09-09 |
DE69621421T2 (de) | 2003-01-09 |
ATE218141T1 (de) | 2002-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC |