ES2176419T3 - Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. - Google Patents
Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.Info
- Publication number
- ES2176419T3 ES2176419T3 ES96402821T ES96402821T ES2176419T3 ES 2176419 T3 ES2176419 T3 ES 2176419T3 ES 96402821 T ES96402821 T ES 96402821T ES 96402821 T ES96402821 T ES 96402821T ES 2176419 T3 ES2176419 T3 ES 2176419T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- aryl
- alkyl
- carbon atoms
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I): EN LOS QUE - X REPRESENTA UN RADICAL (NH){SUB,A}, CH{SUB,2} O SO{SUB,2} O UN ATOMO DE OXIGENO, A REPRESENTA EL NUMERO 0 O 1, - Y REPRESENTA UN RADICAL (CH{SUB,2})M - (CH=CH)N - (CH{SUB,2}) O CON M+N+O INFERIOR O IGUAL A 8, N = 0 O 1, - REPRESENTANDO AR UN RADICAL ARILO, EVENTUALMENTE SUSTITUIDO, HAL REPRESENTA UN ATOMO DE HALOGENO, - REPRESENTANDO Z UN ATOMO DE HIDROGENO O EL RESTO DE UN ACIDO, ASI COMO SUS SALES DE ADICION CON LOS ACIDOS. LOS COMPUESTOS DE FORMULA (I) PRESENTAN INTERESANTES PROPIEDADES ANTIBIOTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9515322A FR2742757B1 (fr) | 1995-12-22 | 1995-12-22 | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176419T3 true ES2176419T3 (es) | 2002-12-01 |
Family
ID=9485837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96402821T Expired - Lifetime ES2176419T3 (es) | 1995-12-22 | 1996-12-19 | Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5747467A (es) |
EP (1) | EP0799833B1 (es) |
JP (1) | JP3140703B2 (es) |
AT (1) | ATE218141T1 (es) |
DE (1) | DE69621421T2 (es) |
DK (1) | DK0799833T3 (es) |
ES (1) | ES2176419T3 (es) |
FR (1) | FR2742757B1 (es) |
PT (1) | PT799833E (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751656B1 (fr) * | 1996-07-24 | 1998-10-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
US6124269A (en) * | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
CO4990960A1 (es) * | 1997-10-29 | 2000-12-26 | Abbott Lab | Derivados de cetolidos 2-halo-6-o sustituidos |
FR2771008B1 (fr) * | 1997-11-17 | 2000-04-28 | Hoechst Marion Roussel Inc | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
FR2777282B1 (fr) * | 1998-04-08 | 2001-04-20 | Hoechst Marion Roussel Inc | Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments |
JP4573925B2 (ja) * | 1998-07-09 | 2010-11-04 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用 |
FR2792637B1 (fr) * | 1999-04-26 | 2001-06-01 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2781484B1 (fr) * | 1998-07-21 | 2001-08-10 | Hoechst Marion Roussel Inc | Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments |
EP1115732B1 (en) * | 1998-09-22 | 2005-06-29 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
FR2784682B1 (fr) | 1998-10-15 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments |
USRE39743E1 (en) * | 1998-10-15 | 2007-07-24 | Aventis Pharma S.A. | 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use |
FR2785612A1 (fr) * | 1998-11-10 | 2000-05-12 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
FR2786188B1 (fr) * | 1998-11-24 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments |
EP1137654A1 (en) | 1998-12-10 | 2001-10-04 | Pfizer Products Inc. | Carbamate and carbazate ketolide antibiotics |
OA11753A (en) * | 1999-01-27 | 2005-07-19 | Pfizer Prod Inc | Ketolide antibiotics. |
FR2789392B1 (fr) * | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
DE60030847T2 (de) | 1999-04-16 | 2007-04-19 | Kosan Biosciences, Inc., Hayward | Antiinfektiöse makrolidderivate |
US6939861B2 (en) * | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
JP2002542197A (ja) | 1999-04-16 | 2002-12-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ケトライド抗菌剤 |
US6355620B1 (en) * | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
AP2001002302A0 (en) * | 1999-05-24 | 2001-10-25 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
JP2001261694A (ja) * | 2000-03-06 | 2001-09-26 | Pfizer Prod Inc | ケトライド抗生物質 |
DK1167376T3 (da) | 2000-06-30 | 2004-10-25 | Pfizer Prod Inc | Makrolidantibiotika |
WO2002050091A1 (en) * | 2000-12-21 | 2002-06-27 | Glaxo Group Limited | Macrolide antibiotics |
PL375162A1 (en) * | 2002-07-08 | 2005-11-28 | Pliva-Istrazivacki Institut D.O.O. | Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules |
NZ537717A (en) * | 2002-07-08 | 2006-04-28 | Pliva Istrazivacki Inst D | New compounds, compositions and methods for treatment of inflammatory diseases and conditions |
US6727229B2 (en) * | 2002-08-19 | 2004-04-27 | Enanta Pharmaceuticals, Inc. | 11,12-substituted lactone ketolide derivatives having antibacterial activity |
US7091196B2 (en) * | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
KR20060002800A (ko) * | 2003-03-05 | 2006-01-09 | 립-엑스 파마슈티칼즈, 인크. | 이관능성 헤테로시클릭 화합물, 및 그의 제조 및 사용 방법 |
ES2552682T3 (es) * | 2003-03-10 | 2015-12-01 | Merck Sharp & Dohme Corp. | Agentes antibacterianos novedosos |
US20050014706A1 (en) * | 2003-07-14 | 2005-01-20 | Kanakeshwari Falzari | Method of treating tuberculosis |
EP1682563A1 (en) * | 2003-10-30 | 2006-07-26 | Rib-X Pharmaceuticals, Inc. | Bifunctional macrolide heterocyclic compounds and mehtods of making and using the same |
US20070270357A1 (en) * | 2003-11-18 | 2007-11-22 | Farmer Jay J | Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same |
EP2716647A3 (en) | 2004-02-27 | 2014-08-20 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
JP2008508322A (ja) * | 2004-07-28 | 2008-03-21 | ランバクシー ラボラトリーズ リミテッド | 抗菌剤としてのケトライド誘導体 |
WO2006046112A2 (en) * | 2004-10-25 | 2006-05-04 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
UA85937C2 (uk) | 2004-12-21 | 2009-03-10 | Пфайзер Продактс Інк. | Макроліди |
US20090130225A1 (en) * | 2005-11-23 | 2009-05-21 | Anjan Chakrabarti | Macrolides derivatives as antibacterial agents |
WO2007060518A2 (en) * | 2005-11-23 | 2007-05-31 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
EP2214484A4 (en) | 2007-10-25 | 2013-01-02 | Cempra Pharmaceuticals Inc | PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS |
EP2358379B1 (en) * | 2008-10-24 | 2015-12-16 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
DK2550286T3 (en) | 2010-03-22 | 2016-02-29 | Cempra Pharmaceuticals Inc | CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF |
EP2571506B1 (en) | 2010-05-20 | 2017-05-10 | Cempra Pharmaceuticals, Inc. | Processes for preparing macrolides and ketolides and intermediates therefor |
EP2613630A4 (en) | 2010-09-10 | 2014-01-15 | Cempra Pharmaceuticals Inc | FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES |
KR20140139083A (ko) | 2012-03-27 | 2014-12-04 | 셈프라 파마슈티컬스, 인크. | 마크롤라이드계 항생제를 투여하기 위한 비경구 제제 |
JP6426696B2 (ja) | 2013-03-14 | 2018-11-21 | センプラ ファーマシューティカルズ,インコーポレイテッド | 呼吸器疾患の治療のための方法および製剤 |
EP2968384A4 (en) | 2013-03-15 | 2017-02-15 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR487411A (fr) * | 1916-03-06 | 1918-07-03 | Henri Dreyfus | Procédé pour la fabrication de l'aldéhyde acétique en partant de l'acétylène |
FR596802A (fr) * | 1924-07-28 | 1925-11-02 | Ste Chim Usines Rhone | Procédé pour rendre la cellulose facilement éthérifiable |
FR676409A (fr) * | 1929-06-08 | 1930-02-22 | Moule multiple | |
FR680967A (fr) * | 1929-08-29 | 1930-05-08 | Perfectionnements à la construction des appareils broyeurs | |
IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
US5527780A (en) * | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
SE9401213L (sv) * | 1994-04-11 | 1995-04-03 | Valeo Engine Cooling Ab | Värmeväxlare placerad i en ränna i en värmeväxlartank |
FR2719587B1 (fr) * | 1994-05-03 | 1996-07-12 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
-
1995
- 1995-12-22 FR FR9515322A patent/FR2742757B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-19 DK DK96402821T patent/DK0799833T3/da active
- 1996-12-19 PT PT96402821T patent/PT799833E/pt unknown
- 1996-12-19 EP EP96402821A patent/EP0799833B1/fr not_active Expired - Lifetime
- 1996-12-19 AT AT96402821T patent/ATE218141T1/de active
- 1996-12-19 ES ES96402821T patent/ES2176419T3/es not_active Expired - Lifetime
- 1996-12-19 DE DE69621421T patent/DE69621421T2/de not_active Expired - Lifetime
- 1996-12-19 US US08/767,954 patent/US5747467A/en not_active Expired - Lifetime
- 1996-12-20 JP JP08354633A patent/JP3140703B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0799833A1 (fr) | 1997-10-08 |
FR2742757B1 (fr) | 1998-01-30 |
PT799833E (pt) | 2002-10-31 |
JPH09176182A (ja) | 1997-07-08 |
EP0799833B1 (fr) | 2002-05-29 |
DK0799833T3 (da) | 2002-09-09 |
ATE218141T1 (de) | 2002-06-15 |
FR2742757A1 (fr) | 1997-06-27 |
JP3140703B2 (ja) | 2001-03-05 |
DE69621421T2 (de) | 2003-01-09 |
US5747467A (en) | 1998-05-05 |
DE69621421D1 (de) | 2002-07-04 |
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