CO4990960A1 - Derivados de cetolidos 2-halo-6-o sustituidos - Google Patents
Derivados de cetolidos 2-halo-6-o sustituidosInfo
- Publication number
- CO4990960A1 CO4990960A1 CO98062730A CO98062730A CO4990960A1 CO 4990960 A1 CO4990960 A1 CO 4990960A1 CO 98062730 A CO98062730 A CO 98062730A CO 98062730 A CO98062730 A CO 98062730A CO 4990960 A1 CO4990960 A1 CO 4990960A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- aryl
- substituted
- heteroaryl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Un compuesto seleccionado del grupo conformado por: y las sales ó ésteres farmacéuticamente aceptables de estos, en donde RP es hidrógeno o un grupo protector de hidroxi; X es F, Cl, Br, o I; y R1 se selecciona del grupo conformado por (1) alquil C1 C6 opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo conformado por (a) aril, (b) aril substituido a través del reemplazo independiente de uno, dos o tres átomos de hidrógeno de dichos grupos con Cl, Br, F, I, OH, CN, alquil C1 -C3 , alcoxi C1 -C6 , alcoxi C1 -C6 substituido con aril, haloalquil, tioalcoxi, amino, alquilamino, dialquilamino, mercapto, nitro, carboxaldehído, carboxi, alcoxicarbonil y carboxamida. Por otra parte, uno cualquiera de los substituyentes puede tratarse de un grupo aril, heteroaril, ó heterocicloalquil (c) heteroaril, (d) heteroaril sustituido a través del reemplazo independiente de uno, dos o tres átomos de hidrógeno de dicho grupo con Cl, Br, F, I, OH, CN, alquil C1 -C3 , alcoxi C1 -C6 , alcoxi C1 -C6 substituido con aril, haloalquil, tioalcoxi, amino, alquilamino, dialquilamino, mercapto, nitro, carboxaldehído, carboxi, alcoxicarbonil, carboxamida, amino N-protegido, -CH(=N-OH), -CH(=N-NH2 ), y -CH(=N-N=C(CH3 )2 )). Además uno cualquiera de los substituyentes puede tratarse de un grupo aril, heteroaril, o uno heterocicloalquil. (e) -NR3 R4 en donde R3 y R4 se seleccionan independientemente entre hidrógeno y alquil C1 -C3 , ó R3 y R4 tomados junto con el átomo al cual van ligados forman un anillo de 3 a 7 miembros que contiene una porción molecular ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95988197A | 1997-10-29 | 1997-10-29 | |
| US15423998A | 1998-09-16 | 1998-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4990960A1 true CO4990960A1 (es) | 2000-12-26 |
Family
ID=26851273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98062730A CO4990960A1 (es) | 1997-10-29 | 1998-10-27 | Derivados de cetolidos 2-halo-6-o sustituidos |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1027362B1 (es) |
| JP (1) | JP2001521039A (es) |
| KR (1) | KR100536420B1 (es) |
| CN (1) | CN1240707C (es) |
| AR (1) | AR015994A1 (es) |
| AT (1) | ATE298760T1 (es) |
| AU (1) | AU751448B2 (es) |
| BG (1) | BG64707B1 (es) |
| BR (1) | BR9813319A (es) |
| CA (1) | CA2307788C (es) |
| CO (1) | CO4990960A1 (es) |
| CZ (1) | CZ300063B6 (es) |
| DE (1) | DE69830739T2 (es) |
| DK (1) | DK1027362T3 (es) |
| ES (1) | ES2244094T3 (es) |
| HK (1) | HK1031383A1 (es) |
| HU (1) | HUP0004282A3 (es) |
| IL (1) | IL135519A0 (es) |
| NO (1) | NO20002190L (es) |
| NZ (1) | NZ503822A (es) |
| PL (1) | PL191453B1 (es) |
| PT (1) | PT1027362E (es) |
| SK (1) | SK286397B6 (es) |
| TR (1) | TR200001142T2 (es) |
| WO (1) | WO1999021871A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39743E1 (en) * | 1998-10-15 | 2007-07-24 | Aventis Pharma S.A. | 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use |
| FR2784682B1 (fr) | 1998-10-15 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments |
| KR100710605B1 (ko) | 1999-04-16 | 2007-04-24 | 코산 바이오사이언시즈, 인코포레이티드 | 매크롤라이드 항감염제 |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| ES2306674T3 (es) * | 1999-12-02 | 2008-11-16 | Abbott Laboratories | Derivados cetolidos 6-o-alquil-2-nor-2-sustituidos. |
| US6569836B2 (en) | 1999-12-02 | 2003-05-27 | Abbott Laboratories | 6-O-alkyl-2-nor-2-substituted ketolide derivatives |
| JP2001261694A (ja) | 2000-03-06 | 2001-09-26 | Pfizer Prod Inc | ケトライド抗生物質 |
| US6605707B1 (en) | 2000-03-23 | 2003-08-12 | Abbott Laboratories | Process for the preparation of 6-O-propargyl erythromycin derivatives |
| EP1167376B1 (en) | 2000-06-30 | 2004-07-14 | Pfizer Products Inc. | Macrolide antibiotics |
| US6472372B1 (en) * | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| US6713455B2 (en) | 2001-09-17 | 2004-03-30 | Ortho-Mcneil Pharmaceutical, Inc. | 6-O-carbamate-11,12-lacto-ketolide antimicrobials |
| HUP0500018A3 (en) | 2001-12-05 | 2009-09-28 | Ortho Mcneil Pharm Inc | 6-o-acyl ketolide derivatives of erythromycine processes for preparing them and using them as antibacterials |
| JP2005522453A (ja) * | 2002-02-13 | 2005-07-28 | アボット・ラボラトリーズ | マクロライド抗菌化合物 |
| WO2003090761A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | 9-oxime macrolide antibacterials |
| JP2005528409A (ja) * | 2002-04-25 | 2005-09-22 | アボット・ラボラトリーズ | オキソリド抗菌薬 |
| WO2004078771A1 (ja) * | 2003-03-07 | 2004-09-16 | Taisho Pharmaceutical Co., Ltd. | ２－フルオロ－６－ｏ－置換ケトライド誘導体 |
| JP2007254285A (ja) * | 2004-03-16 | 2007-10-04 | Taisho Pharmaceut Co Ltd | ２−フルオロ−６−ｏ−置換ケトライド誘導体 |
| CN102459296B (zh) * | 2009-05-27 | 2014-10-29 | 沃克哈特研究中心 | 具有抗微生物活性的酮内酯类化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of the history of erythromycin |
| US5591837A (en) * | 1992-04-22 | 1997-01-07 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide a derivative |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
-
1998
- 1998-10-27 CO CO98062730A patent/CO4990960A1/es unknown
- 1998-10-28 AR ARP980105407A patent/AR015994A1/es unknown
- 1998-10-29 AT AT98956338T patent/ATE298760T1/de not_active IP Right Cessation
- 1998-10-29 JP JP2000517980A patent/JP2001521039A/ja active Pending
- 1998-10-29 CZ CZ20001525A patent/CZ300063B6/cs not_active IP Right Cessation
- 1998-10-29 HU HU0004282A patent/HUP0004282A3/hu unknown
- 1998-10-29 BR BR9813319-5A patent/BR9813319A/pt not_active Application Discontinuation
- 1998-10-29 WO PCT/US1998/022989 patent/WO1999021871A1/en active IP Right Grant
- 1998-10-29 CN CNB988127326A patent/CN1240707C/zh not_active Expired - Fee Related
- 1998-10-29 ES ES98956338T patent/ES2244094T3/es not_active Expired - Lifetime
- 1998-10-29 EP EP98956338A patent/EP1027362B1/en not_active Expired - Lifetime
- 1998-10-29 PL PL340290A patent/PL191453B1/pl not_active IP Right Cessation
- 1998-10-29 AU AU12881/99A patent/AU751448B2/en not_active Ceased
- 1998-10-29 IL IL13551998A patent/IL135519A0/xx not_active IP Right Cessation
- 1998-10-29 TR TR2000/01142T patent/TR200001142T2/xx unknown
- 1998-10-29 PT PT98956338T patent/PT1027362E/pt unknown
- 1998-10-29 SK SK633-2000A patent/SK286397B6/sk not_active IP Right Cessation
- 1998-10-29 NZ NZ503822A patent/NZ503822A/xx unknown
- 1998-10-29 KR KR10-2000-7004613A patent/KR100536420B1/ko not_active IP Right Cessation
- 1998-10-29 CA CA002307788A patent/CA2307788C/en not_active Expired - Fee Related
- 1998-10-29 DE DE69830739T patent/DE69830739T2/de not_active Expired - Lifetime
- 1998-10-29 DK DK98956338T patent/DK1027362T3/da active
-
2000
- 2000-04-27 NO NO20002190A patent/NO20002190L/no not_active Application Discontinuation
- 2000-05-15 BG BG104434A patent/BG64707B1/bg unknown
-
2001
- 2001-02-05 HK HK01100816A patent/HK1031383A1/xx not_active IP Right Cessation
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