AR015994A1 - Derivados de cetolidos 2-halo-6-o-sustituidos, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procesos parasu preparacion - Google Patents
Derivados de cetolidos 2-halo-6-o-sustituidos, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procesos parasu preparacionInfo
- Publication number
- AR015994A1 AR015994A1 ARP980105407A ARP980105407A AR015994A1 AR 015994 A1 AR015994 A1 AR 015994A1 AR P980105407 A ARP980105407 A AR P980105407A AR P980105407 A ARP980105407 A AR P980105407A AR 015994 A1 AR015994 A1 AR 015994A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- aryl
- heteroaryl
- group
- oyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Derivados de cetolidos 2-halo-6-O-sustituidos y sus sales y ésteres farmacéuticamente aceptables que tienen actividad antibacteriana que tienen una formula(I) y (II) y sus sales y ésteres farmacéuticamente aceptables, en donde Rp es hidrogeno o ungr upo protector de hidroxi; X es F, Cl, Br o I; y R1 se seleccionaentre el grupo que consiste en (I) alquilo C1-6 optativamente sustituido con uno o más sustituyentes seleccionados entre el grupo que consiste en (a) arilo,(b) arilo sustituido, (c)hete roarilo, (d) heteroarilo sustituido, (e) -NR3R4 en donde R3 y R4 son independientemente seleccionados entre hidrogeno y alquiloC1-C3,o R3 y R4 se toman conjuntamente con el átomo al cual están unidos forman un anillo de 3-7 miembros quecontienen una porcion seleccionada entre el grupoque consiste en -O-,-NH-,-N(arilalquilo C1-6), N(arilalquilo- C1-6)-, -N(arilalquilo- C1-6 sustituido)-,-N(heteroarilalquilo-C1-6)- y -N(heteroarilalquilo C1-6sustituido)-; (2) -CH2-CH=CH-Y, en dondeY se seleccion a entre el grupo que consiste en (a)H, (b) arilo, (c) arilo sustituido, (d) heteroarilo, (e) heteroarilosustituido; (f) -CH=H2, (g) -CH=CH arilo, (h) -CH=CH-arilo sustituido, (i) -CH=CH-heteroarilo y (j) -CH=CH-heteroarilo sustituido,(k) (aril)oilo, (l) (arilsustituido)oilo, (m)(heteroaril)oilo y (n)(heteroaril sustituido)oilo; y (3) -CH2-C:::C-Y en donde Y es como se define previamente, con la condicion de que loscompuestos de formula (II) en donde R1 se selecciona de la opcion(1) el grupo al quilo C1-C6 debe ser sustituido; composiciones que comprende una cantidadterapéuticamente efectiva de dicho compuesto en combinacion con un vehículo farmacéuticamente aceptable, su uso para la manufactura de un medicamento utilparatratar infecciones bacterianas que compendre una composicion farmacéutica que contiene una cantidad terapéuticamente efectiva de dicho compuesto, y procesospara su preparacion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95988197A | 1997-10-29 | 1997-10-29 | |
| US15423998A | 1998-09-16 | 1998-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015994A1 true AR015994A1 (es) | 2001-05-30 |
Family
ID=26851273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105407A AR015994A1 (es) | 1997-10-29 | 1998-10-28 | Derivados de cetolidos 2-halo-6-o-sustituidos, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procesos parasu preparacion |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1027362B1 (es) |
| JP (1) | JP2001521039A (es) |
| KR (1) | KR100536420B1 (es) |
| CN (1) | CN1240707C (es) |
| AR (1) | AR015994A1 (es) |
| AT (1) | ATE298760T1 (es) |
| AU (1) | AU751448B2 (es) |
| BG (1) | BG64707B1 (es) |
| BR (1) | BR9813319A (es) |
| CA (1) | CA2307788C (es) |
| CO (1) | CO4990960A1 (es) |
| CZ (1) | CZ300063B6 (es) |
| DE (1) | DE69830739T2 (es) |
| DK (1) | DK1027362T3 (es) |
| ES (1) | ES2244094T3 (es) |
| HK (1) | HK1031383A1 (es) |
| HU (1) | HUP0004282A3 (es) |
| IL (1) | IL135519A0 (es) |
| NO (1) | NO20002190L (es) |
| NZ (1) | NZ503822A (es) |
| PL (1) | PL191453B1 (es) |
| PT (1) | PT1027362E (es) |
| SK (1) | SK286397B6 (es) |
| TR (1) | TR200001142T2 (es) |
| WO (1) | WO1999021871A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2784682B1 (fr) | 1998-10-15 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments |
| USRE39743E1 (en) * | 1998-10-15 | 2007-07-24 | Aventis Pharma S.A. | 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use |
| WO2000063224A2 (en) * | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| CA2391297C (en) * | 1999-12-02 | 2009-01-06 | Abbott Laboratories | 6-o-alkyl-2-nor-2-substituted ketolide derivatives |
| US6569836B2 (en) | 1999-12-02 | 2003-05-27 | Abbott Laboratories | 6-O-alkyl-2-nor-2-substituted ketolide derivatives |
| JP2001261694A (ja) | 2000-03-06 | 2001-09-26 | Pfizer Prod Inc | ケトライド抗生物質 |
| US6605707B1 (en) * | 2000-03-23 | 2003-08-12 | Abbott Laboratories | Process for the preparation of 6-O-propargyl erythromycin derivatives |
| DE60104240T2 (de) | 2000-06-30 | 2005-08-04 | Pfizer Products Inc., Groton | Makrolid-Antibiotika |
| US6472372B1 (en) * | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| US6713455B2 (en) | 2001-09-17 | 2004-03-30 | Ortho-Mcneil Pharmaceutical, Inc. | 6-O-carbamate-11,12-lacto-ketolide antimicrobials |
| CA2469304A1 (en) | 2001-12-05 | 2003-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o acyl ketolide antibacterials |
| MXPA04007883A (es) * | 2002-02-13 | 2004-11-26 | Abbott Lab | Compuestos antimicrobianos de macrolido. |
| WO2003090761A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | 9-oxime macrolide antibacterials |
| CA2483220A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | Oxolide antibacterials |
| WO2004078771A1 (ja) * | 2003-03-07 | 2004-09-16 | Taisho Pharmaceutical Co., Ltd. | ２－フルオロ－６－ｏ－置換ケトライド誘導体 |
| JP2007254285A (ja) * | 2004-03-16 | 2007-10-04 | Taisho Pharmaceut Co Ltd | ２−フルオロ−６−ｏ−置換ケトライド誘導体 |
| WO2010136971A1 (en) * | 2009-05-27 | 2010-12-02 | Wockhardt Research Centre | Ketolide compounds having antimicrobial activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| KR0166996B1 (ko) * | 1992-04-22 | 1999-01-15 | 우에하라 아키라 | 5-o-데소사미닐에리쓰로노라이드a 유도체 |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
-
1998
- 1998-10-27 CO CO98062730A patent/CO4990960A1/es unknown
- 1998-10-28 AR ARP980105407A patent/AR015994A1/es unknown
- 1998-10-29 AT AT98956338T patent/ATE298760T1/de not_active IP Right Cessation
- 1998-10-29 KR KR10-2000-7004613A patent/KR100536420B1/ko not_active IP Right Cessation
- 1998-10-29 CZ CZ20001525A patent/CZ300063B6/cs not_active IP Right Cessation
- 1998-10-29 CN CNB988127326A patent/CN1240707C/zh not_active Expired - Fee Related
- 1998-10-29 WO PCT/US1998/022989 patent/WO1999021871A1/en active IP Right Grant
- 1998-10-29 HU HU0004282A patent/HUP0004282A3/hu unknown
- 1998-10-29 DK DK98956338T patent/DK1027362T3/da active
- 1998-10-29 EP EP98956338A patent/EP1027362B1/en not_active Expired - Lifetime
- 1998-10-29 PT PT98956338T patent/PT1027362E/pt unknown
- 1998-10-29 IL IL13551998A patent/IL135519A0/xx not_active IP Right Cessation
- 1998-10-29 SK SK633-2000A patent/SK286397B6/sk not_active IP Right Cessation
- 1998-10-29 CA CA002307788A patent/CA2307788C/en not_active Expired - Fee Related
- 1998-10-29 DE DE69830739T patent/DE69830739T2/de not_active Expired - Lifetime
- 1998-10-29 AU AU12881/99A patent/AU751448B2/en not_active Ceased
- 1998-10-29 ES ES98956338T patent/ES2244094T3/es not_active Expired - Lifetime
- 1998-10-29 TR TR2000/01142T patent/TR200001142T2/xx unknown
- 1998-10-29 BR BR9813319-5A patent/BR9813319A/pt not_active Application Discontinuation
- 1998-10-29 JP JP2000517980A patent/JP2001521039A/ja active Pending
- 1998-10-29 PL PL340290A patent/PL191453B1/pl not_active IP Right Cessation
- 1998-10-29 NZ NZ503822A patent/NZ503822A/xx unknown
-
2000
- 2000-04-27 NO NO20002190A patent/NO20002190L/no not_active Application Discontinuation
- 2000-05-15 BG BG104434A patent/BG64707B1/bg unknown
-
2001
- 2001-02-05 HK HK01100816A patent/HK1031383A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |