HUP0101793A2 - Antranilsav-származékok, mint cGMP-foszfodiészteráz gátlók - Google Patents

Antranilsav-származékok, mint cGMP-foszfodiészteráz gátlók

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Publication number
HUP0101793A2
HUP0101793A2 HU0101793A HUP0101793A HUP0101793A2 HU P0101793 A2 HUP0101793 A2 HU P0101793A2 HU 0101793 A HU0101793 A HU 0101793A HU P0101793 A HUP0101793 A HU P0101793A HU P0101793 A2 HUP0101793 A2 HU P0101793A2
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HU
Hungary
Prior art keywords
group
short
substituted
chain alkyl
carbon
Prior art date
Application number
HU0101793A
Other languages
English (en)
Inventor
Takayuki Inoue
Natsuko Kayakiri
Akio Kuroda
Tsuyoshi Mizutani
Teruo Oku
Kozo Sawada
Yuki Sawada
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from AUPP3085A external-priority patent/AUPP308598A0/en
Priority claimed from AUPP5851A external-priority patent/AUPP585198A0/en
Priority claimed from AUPP7781A external-priority patent/AUPP778198A0/en
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HUP0101793A2 publication Critical patent/HUP0101793A2/hu
Publication of HUP0101793A3 publication Critical patent/HUP0101793A3/hu

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Hospice & Palliative Care (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgya (I) általános képletű vegyület; annak előhatóanyagavagy sója, ahol a képletben R1 jelentése hidrogén- vagy halogénatom;R2 jelentése elektronvonzó csoport; R3 jelentése hidrogénatom,hidroxil-, rövidszénláncú alkoxi-, cikloalkil-, helyettesített vagyhelyettesítetlen aril- vagy telítetlen heterociklusos csoport, melyadott esetben rövidszénláncú alkilcsoporttal lehet helyettesített; Ajelentése rövidszénláncú alkiléncsoport; R4 jelentése rövidszénláncúalkoxicsoport, helyettesített vagy helyettesítetlen, telített vagytelítetlen heterociklusos csoport, aminocsoport, mely adott esetbenrövidszénláncú alkilcsoporttal vagy halogénezett rövidszénláncúalkilcsoporttal helyettesített; R4 további jelentése -CH2-R5 általánosképletű csoport, melyben belül R5 jelentése cikloalkilcsoport vagytelítetlen heterociklusos csoport; vagy R4 további jelentése -CR6R7R8általános képletű csoport, melyen belül R6 és R7 jelentése egymástólfüggetlenül karboxilcsoport, védett karboxilcsoport, karbamoilcsoport,mely adott esetben rövidszénláncú alkilcsoporttal helyettesített, vagyrövid szénláncú alkilcsoport, mely adott esetben egy vagy több alábbiszubsztituenssel helyettesített: halogénatom; hidroxil-; ciano-;azido-; rövidszénláncú alkoxi-; rövidszénláncú alkil-tio-; védettkarboxil-; rövid szénláncú alkánszulfonil-; acil-oxi-; rövidszénláncúalkánszulfonil-oxi-; aril-; aril-oxi-csoport, mely helyettesítettlehet cianocsoporttal; telítetlen heterociklusos csoport - melyhelyettesített lehet rövidszénláncú alkilcsoporttal; guanidinocsoport,mely helyettesített lehet rövidszénláncú alkil-, cianocsoporttalés/vagy halogénatommal; izotioureido-csoport, mely helyettesítettlehet rövidszénláncú alkil- és/vagy cianocsoporttal; és aminocsoport,ami helyettesített lehet acil-, védett karboxil-, rövidszénláncúalkánszulfonil-, rövidszénláncú alkánszulfonil-oxi- vagy aril-oxi-karbonil-csoporttal; vagy R6 és R7 a szénatommal, melyhezkapcsolódnak, képezhetnek egy helyettesített vagy helyettesítetlen,telített széngyűrűs csoportot; vagy egy telítetlen széngyűrűscsoportot, ami adott esetben hidroxilcsoporttal helyettesített; és R8jelentése hidrogénatom, rövidszénláncú alkoxi-, vagy rövidszénláncúalkilcsoport, mely adott esetben hidroxil- vagy rövidszénlácnúalkoxicsoporttal helyettesített; feltéve, hogy, ha R4 jelentése -CR6R7R8 általános képletű csoport, melyen belül R6 jelentése adottesetben halogénatommal helyettesített rövidszénláncú alkilcsoport; R7jelentése adott esetben halogénatommal helyettesített rövidszénláncúalkilcsoport, és R8 jelentése hidrogénatom vagy rövidszénláncúalkilcsoport, vagy ha R4 jelentése -CH2R5 általános képletű csoport,melyen belül R5 jelentése a fentiekben meghatározott, akkor R3jelentése hidrogénatom, hidroxilcsoport vagy cikloalkilcsoport kelllegyen - valamint ide tartoznak e vegyületek előhatóanyaga
HU0101793A 1998-04-20 1999-04-15 Anthranilic acid derivatives as inhibitors of the cgmp-phosphodiesterase HUP0101793A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPP3085A AUPP308598A0 (en) 1998-04-20 1998-04-20 Anthranilic acid derivatives
AUPP5851A AUPP585198A0 (en) 1998-09-11 1998-09-11 Anthranilic acid derivatives
AUPP7781A AUPP778198A0 (en) 1998-12-18 1998-12-18 Anthranilic acid derivatives
PCT/JP1999/002028 WO1999054284A1 (en) 1998-04-20 1999-04-15 Anthranilic acid derivatives as inhibitors of the cgmp-phosphodiesterase

Publications (2)

Publication Number Publication Date
HUP0101793A2 true HUP0101793A2 (hu) 2001-10-28
HUP0101793A3 HUP0101793A3 (en) 2003-02-28

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Application Number Title Priority Date Filing Date
HU0101793A HUP0101793A3 (en) 1998-04-20 1999-04-15 Anthranilic acid derivatives as inhibitors of the cgmp-phosphodiesterase

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US (2) US6384080B1 (hu)
EP (1) EP1080069B1 (hu)
JP (1) JP2001508811A (hu)
KR (1) KR20010042851A (hu)
CN (1) CN1305454A (hu)
AR (1) AR020321A1 (hu)
AT (1) ATE234810T1 (hu)
BR (1) BR9909781A (hu)
CA (1) CA2328413A1 (hu)
DE (1) DE69906059D1 (hu)
HU (1) HUP0101793A3 (hu)
IL (1) IL138969A0 (hu)
TR (1) TR200003037T2 (hu)
WO (1) WO1999054284A1 (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693123B2 (en) * 1995-11-06 2004-02-17 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
AUPQ365299A0 (en) * 1999-10-25 1999-11-18 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives
WO2001060353A1 (fr) * 2000-02-21 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. Preparation liquide a absorbabilite amelioree
CN1436080A (zh) 2000-04-19 2003-08-13 利利艾科斯有限公司 环gmp－特异性磷酸二酯酶抑制剂治疗帕金森氏病的用途
EP1275386A1 (en) * 2000-04-19 2003-01-15 Fujisawa Pharmaceutical Co., Ltd. Solid dispersion with improved absorbability
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
US20030073945A1 (en) * 2001-10-17 2003-04-17 Liang-Kuang Diang Ozone hemodiafiltration device
AU2003212335B8 (en) * 2002-03-13 2009-04-23 Janssen Pharmaceutica N.V. Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
PL377712A1 (pl) 2003-02-13 2006-02-06 Wellstat Therapeutics Corporation Związki do leczenia zaburzeń metabolicznych
EP1626962B1 (en) * 2003-05-12 2007-02-28 Pfizer Products Inc. Benzamide inhibitors of the p2x7 receptor
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US20080051413A1 (en) * 2006-08-25 2008-02-28 Kaohsiung Medical University Nitrophenylpiperazine derivative of xanthine which relaxes tracheal airway and increases respiratory performance
EP2131843B1 (en) 2007-03-05 2011-11-09 F. Hoffmann-La Roche AG Process for the synthesis of glyt-1 inhibitors
WO2008112164A2 (en) * 2007-03-08 2008-09-18 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US8299123B2 (en) * 2007-10-19 2012-10-30 Boehringer Ingelheim International Gmbh CCR10 antagonists
JP2012502048A (ja) 2008-09-08 2012-01-26 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法
KR20110082180A (ko) 2008-10-28 2011-07-18 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 알데히드 탈수소효소의 조절자 및 그것의 사용방법
FR2944282B1 (fr) * 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
FR2944206B1 (fr) 2009-04-09 2012-12-28 Sanofi Aventis Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione
WO2010119877A1 (ja) * 2009-04-13 2010-10-21 味の素株式会社 アミジン誘導体の製造方法
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
JP6410790B2 (ja) 2013-03-14 2018-10-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法
CN104873482B (zh) * 2015-05-05 2017-12-01 青岛市市立医院 一种抗慢性心力衰竭的药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2611705A1 (de) 1976-03-18 1977-09-22 Josef Dipl Chem Dr Rer N Klosa N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
NZ277556A (en) 1993-12-27 1997-06-24 Eisai Co Ltd N-phenyl(alkyl)- and n-pyridyl(alkyl)anthranilic acid derivatives; intermediates
KR100430059B1 (ko) 1995-04-10 2004-09-24 후지사와 야꾸힝 고교 가부시키가이샤 cGMP-PDE억제제로서의인돌유도체
JPH0959236A (ja) 1995-08-23 1997-03-04 Dai Ichi Seiyaku Co Ltd ベンズアミド化合物

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ATE234810T1 (de) 2003-04-15
KR20010042851A (ko) 2001-05-25
IL138969A0 (en) 2001-11-25
WO1999054284A1 (en) 1999-10-28
HUP0101793A3 (en) 2003-02-28
US20020193614A1 (en) 2002-12-19
US6384080B1 (en) 2002-05-07
JP2001508811A (ja) 2001-07-03
CA2328413A1 (en) 1999-10-28
DE69906059D1 (de) 2003-04-24
BR9909781A (pt) 2000-12-19
EP1080069A1 (en) 2001-03-07

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