HUP0100978A2 - Benzotiadiazolok és származékaik, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Benzotiadiazolok és származékaik, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0100978A2 HUP0100978A2 HU0100978A HUP0100978A HUP0100978A2 HU P0100978 A2 HUP0100978 A2 HU P0100978A2 HU 0100978 A HU0100978 A HU 0100978A HU P0100978 A HUP0100978 A HU P0100978A HU P0100978 A2 HUP0100978 A2 HU P0100978A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- hydrogen
- benzothiadiazoles
- derivatives
- Prior art date
Links
- FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical class C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- -1 oxy- Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Pulmonology (AREA)
- Pregnancy & Childbirth (AREA)
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- Rheumatology (AREA)
- Virology (AREA)
- Diabetes (AREA)
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- Obesity (AREA)
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- Molecular Biology (AREA)
- Anesthesiology (AREA)
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Abstract
A találmány szabad bázis vagy savaddíciós só formájában lévő (I)általános képletű vegyületekre - amelyek képletében X oxi-, tio-,metil-imino-, viniléncsoport vagy -C(Alk)=C(Alk)-, amelyben Alkalkilcsoport, R1 és R2 hidrogén-, halogénatom, alkil-, alkoxi- vagytrifluor-metil-csoport, és Het egy (a)-(p) általános képletű csoport,ahol R3 és R8 hidrogénatom vagy alkilcsoport, R4 hidrogén-,halogénatom, alkil-, ciano-, nitro-, formil- vagy alkil-karbonilcsoport, R5 és R6 hidrogénatom, alkil-, alkenil-, cikloalkil-,cikloalkil-alkil-, alkoxi-alkil- vagy benzilcsoport, R7 hidrogénatom,hidroxicsoport, alkil- vagy alkoxicsoport, W =N-, <C-CN, <C-NO2, <C-COH vagy <C-CO-Alk csoport, ahol Alk a fentiekben meghatározott, és Xa fentiekben meghatározott - és előállításukra, gyógyszerként történőalkalmazásukra, valamint a vegyületeket tartalmazógyógyszerkészítményekre vonatkozik. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9802251.0A GB9802251D0 (en) | 1998-02-03 | 1998-02-03 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100978A2 true HUP0100978A2 (hu) | 2002-05-29 |
| HUP0100978A3 HUP0100978A3 (en) | 2003-08-28 |
Family
ID=10826354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100978A HUP0100978A3 (en) | 1998-02-03 | 1999-02-01 | Benzothiadiazoles and derivatives, process for their preparation and medicaments containing them |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1049694B1 (hu) |
| JP (1) | JP3455180B2 (hu) |
| KR (2) | KR100502880B1 (hu) |
| CN (1) | CN1119346C (hu) |
| AR (1) | AR015222A1 (hu) |
| AT (1) | ATE217622T1 (hu) |
| AU (1) | AU745051B2 (hu) |
| BR (1) | BR9909739A (hu) |
| CA (1) | CA2318977A1 (hu) |
| CO (1) | CO4990932A1 (hu) |
| DE (1) | DE69901483T2 (hu) |
| DK (1) | DK1049694T3 (hu) |
| ES (1) | ES2178451T3 (hu) |
| GB (1) | GB9802251D0 (hu) |
| HK (1) | HK1033578A1 (hu) |
| HU (1) | HUP0100978A3 (hu) |
| ID (1) | ID26156A (hu) |
| IL (1) | IL137332A (hu) |
| MY (1) | MY122453A (hu) |
| NO (1) | NO316913B1 (hu) |
| NZ (1) | NZ505970A (hu) |
| PE (1) | PE20000246A1 (hu) |
| PL (1) | PL194838B1 (hu) |
| PT (1) | PT1049694E (hu) |
| RU (1) | RU2219177C2 (hu) |
| SK (1) | SK283833B6 (hu) |
| TR (1) | TR200002237T2 (hu) |
| TW (1) | TW509689B (hu) |
| WO (1) | WO1999040089A1 (hu) |
| ZA (1) | ZA99800B (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| GB0302876D0 (en) * | 2003-02-07 | 2003-03-12 | Novartis Ag | Organic compounds |
| CN104383542B (zh) | 2003-04-08 | 2017-09-26 | 普罗热尼奇制药公司 | 包含甲基纳曲酮的药物配方 |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| WO2007149938A2 (en) | 2006-06-21 | 2007-12-27 | The Salk Institute Biological Studies | Methods for promoting hair growth |
| EP3263571B2 (en) | 2007-03-29 | 2023-08-23 | Progenics Pharmaceuticals, Inc. | Crystal form of (r)-n-methylnaltrexone bromide and uses thereof |
| US8338446B2 (en) | 2007-03-29 | 2012-12-25 | Wyeth Llc | Peripheral opioid receptor antagonists and uses thereof |
| PE20130480A1 (es) | 2007-03-29 | 2013-05-08 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
| WO2009099411A1 (en) | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| US20120295942A1 (en) | 2010-02-01 | 2012-11-22 | Nicholas James Devereux | Pyrazolo[5,1b]oxazole Derivatives as CRF-1 Receptor Antagonists |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
| AR086554A1 (es) | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
| CN104271579A (zh) | 2012-05-03 | 2015-01-07 | 诺华股份有限公司 | 作为生长素释放肽受体激动剂的2,7-二氮杂-螺[4,5]癸烷-7-基衍生物的l-苹果酸盐及其结晶 |
| CA3039026A1 (en) | 2016-09-07 | 2018-03-15 | The Regents Of The University Of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2499991A1 (fr) * | 1981-02-19 | 1982-08-20 | Sandoz Sa | Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments |
| KR0163624B1 (ko) * | 1992-04-28 | 1998-12-01 | 오노다 마사요시 | 신규의 치환된 3급 아미노 화합물 또는 이의 염 |
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
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1998
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1999
- 1999-01-27 CO CO99004377A patent/CO4990932A1/es unknown
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- 1999-02-01 KR KR10-2004-7015274A patent/KR100502880B1/ko not_active IP Right Cessation
- 1999-02-01 DK DK99934200T patent/DK1049694T3/da active
- 1999-02-01 HU HU0100978A patent/HUP0100978A3/hu unknown
- 1999-02-01 CA CA002318977A patent/CA2318977A1/en not_active Abandoned
- 1999-02-01 PE PE1999000070A patent/PE20000246A1/es not_active Application Discontinuation
- 1999-02-01 AU AU32521/99A patent/AU745051B2/en not_active Ceased
- 1999-02-01 EP EP99934200A patent/EP1049694B1/en not_active Expired - Lifetime
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- 1999-02-01 KR KR10-2000-7008418A patent/KR100507250B1/ko not_active IP Right Cessation
- 1999-02-01 DE DE69901483T patent/DE69901483T2/de not_active Expired - Lifetime
- 1999-02-01 PL PL342008A patent/PL194838B1/pl not_active IP Right Cessation
- 1999-02-01 TR TR2000/02237T patent/TR200002237T2/xx unknown
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- 1999-02-01 BR BR9909739-7A patent/BR9909739A/pt not_active Application Discontinuation
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- 1999-02-01 JP JP2000530518A patent/JP3455180B2/ja not_active Expired - Fee Related
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2000
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