ES2178451T3 - Derivados de benzoxadiazoles, benzotiadiazoles, benzotriazoles y quinoxalinas. - Google Patents

Derivados de benzoxadiazoles, benzotiadiazoles, benzotriazoles y quinoxalinas.

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Publication number
ES2178451T3
ES2178451T3 ES99934200T ES99934200T ES2178451T3 ES 2178451 T3 ES2178451 T3 ES 2178451T3 ES 99934200 T ES99934200 T ES 99934200T ES 99934200 T ES99934200 T ES 99934200T ES 2178451 T3 ES2178451 T3 ES 2178451T3
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Spain
Prior art keywords
alkyl
alk
alkoxy
hydrogen
quinoxalinas
Prior art date
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Expired - Lifetime
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ES99934200T
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English (en)
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Bernhard Peter Neumann
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Novartis AG
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Novartis AG
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

Un compuesto de fórmula I **(Fórmula)** en donde X es O, S, N-CH3, CH=CH o CAlk=CAlk en donde los Alk son independientemente alquilo C1-4; R1 y R2 son independientemente hidrógeno, halógeno, alquilo C1-4, alcoxi C1-4 o trifluormetilo; y Het es un radical que tiene una de las siguientes fórmulas (a) a (p): **(Fórmulas)** en donde R3 y R8 son independientemente hidrógeno o alquilo C1-4; R4 es hidrógeno, halógeno, alquilo C1-4, ciano, nitro, formilo o alquil(C1-4) carbonilo; R5 y R6 son independientemente hidrógeno, alquilo C1-7, alquenilo C3-7, cicloalquilo C3-7, cicloalquil(C3-7)alquilo C1-4, alcoxi (C1-4)alquilo C2-5 o bencilo; R7 es hidrógeno, hidroxi, alquilo C1-4 o alcoxi C1-4; W es N, C-CN, C-NO2, C-COH o C-CO-Alk en donde Alk se define como anteriormente; y X se define como anteriormente; en forma de la base libre o de una sal de adición de ácido.
ES99934200T 1998-02-03 1999-02-01 Derivados de benzoxadiazoles, benzotiadiazoles, benzotriazoles y quinoxalinas. Expired - Lifetime ES2178451T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9802251.0A GB9802251D0 (en) 1998-02-03 1998-02-03 Organic compounds

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ES2178451T3 true ES2178451T3 (es) 2002-12-16

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EP (1) EP1049694B1 (es)
JP (1) JP3455180B2 (es)
KR (2) KR100507250B1 (es)
CN (1) CN1119346C (es)
AR (1) AR015222A1 (es)
AT (1) ATE217622T1 (es)
AU (1) AU745051B2 (es)
BR (1) BR9909739A (es)
CA (1) CA2318977A1 (es)
CO (1) CO4990932A1 (es)
DE (1) DE69901483T2 (es)
DK (1) DK1049694T3 (es)
ES (1) ES2178451T3 (es)
GB (1) GB9802251D0 (es)
HU (1) HUP0100978A3 (es)
ID (1) ID26156A (es)
IL (1) IL137332A (es)
MY (1) MY122453A (es)
NO (1) NO316913B1 (es)
NZ (1) NZ505970A (es)
PE (1) PE20000246A1 (es)
PL (1) PL194838B1 (es)
PT (1) PT1049694E (es)
RU (1) RU2219177C2 (es)
SK (1) SK283833B6 (es)
TR (1) TR200002237T2 (es)
TW (1) TW509689B (es)
WO (1) WO1999040089A1 (es)
ZA (1) ZA99800B (es)

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US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
UY34094A (es) 2011-05-27 2013-01-03 Novartis Ag Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
TW201348235A (zh) 2012-05-03 2013-12-01 Novartis Ag 作爲格瑞啉受體促效劑之３－螺環哌啶衍生物
KR102571296B1 (ko) * 2016-09-07 2023-08-28 더 리전트 오브 더 유니버시티 오브 캘리포니아 P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제

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JP3455180B2 (ja) 2003-10-14
EP1049694B1 (en) 2002-05-15
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HUP0100978A2 (hu) 2002-05-29
KR20040097226A (ko) 2004-11-17
GB9802251D0 (en) 1998-04-01
IL137332A0 (en) 2001-07-24
TR200002237T2 (tr) 2000-12-21
NO20003916L (no) 2000-09-28
JP2002502853A (ja) 2002-01-29
AU745051B2 (en) 2002-03-07
PE20000246A1 (es) 2000-05-15
DE69901483T2 (de) 2002-10-31
HUP0100978A3 (en) 2003-08-28
KR100502880B1 (ko) 2005-07-21
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PL194838B1 (pl) 2007-07-31
PT1049694E (pt) 2002-09-30
NO316913B1 (no) 2004-06-21
CA2318977A1 (en) 1999-08-12
SK283833B6 (sk) 2004-03-02
DE69901483D1 (de) 2002-06-20
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ATE217622T1 (de) 2002-06-15
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