CO4990932A1 - Derivados de 2,1,3-benzotiadiazol y proceso para su preparacion - Google Patents

Derivados de 2,1,3-benzotiadiazol y proceso para su preparacion

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Publication number
CO4990932A1
CO4990932A1 CO99004377A CO99004377A CO4990932A1 CO 4990932 A1 CO4990932 A1 CO 4990932A1 CO 99004377 A CO99004377 A CO 99004377A CO 99004377 A CO99004377 A CO 99004377A CO 4990932 A1 CO4990932 A1 CO 4990932A1
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Colombia
Prior art keywords
carbon atoms
alkyl
alk
alkoxy
hydrogen
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CO99004377A
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English (en)
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Bernhard Peter Neumann
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Novartis Ag
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Publication of CO4990932A1 publication Critical patent/CO4990932A1/es

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Abstract

La presente invención se relaciona con un compuesto de lafórmula I:en donde:X es O, S, N-CH3 , CH=CH ó CALK = CALK, en donde ALK es independientemente alquilo (de 1 a 4 átomos de carbono),R1 y R2 son independientemente hidrógeno, halógeno, alquilo (de 1 a 4 átomos de carbono), alcoxi (de 1 a4 átomos de carbono), ó trifluorometilo, yHet es un radical que tiene una de las fórmulas (a) a (p) siguiente:en donde:R3 y R8 son independientemente hidrógeno o alquilo (de 1 a 4 átomos de carbono),R4 es hidrógeno, alquilo (de 1 a 4 átomos de carbono), ciano, nitro, formilo ó alquilo (de 1 a 4 átomos de carbono)-carbonilo,R5 y R6 , son independientemente hidrógeno, alquilo (de 1 a 7 átomos de carbono), alquilo (de 3 a 7 átomos de carbono), cicloalquilo (de 3 a 7 átomos de carbono), cicloalquilo (de 3 a 7 átomos de carbono)- alquilo (de 1 a 4 átomos de carbono), alcoxi (de 1 a 4 átomos de carbono)-alquilo (de 2 a 5 átomos de carbono) ó bencilo,R7 es hidrógeno, hidroxi, alquilo (de 1 a 4 átomos de carbono, ó alcoxi (de 1 a 4 átomos de carbono),W es N, C-NO2 , C-CH ó C-CO-Alk, en donde Alk es como se define anteriormente, yX es como se define anteriormente, en forma de base libre ó de sal de adición de ácido.
CO99004377A 1998-02-03 1999-01-27 Derivados de 2,1,3-benzotiadiazol y proceso para su preparacion CO4990932A1 (es)

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GBGB9802251.0A GB9802251D0 (en) 1998-02-03 1998-02-03 Organic compounds

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EP3510029A4 (en) * 2016-09-07 2020-03-11 The Regents of The University of California ALLOSTERIC CORTICOTROPIN RELEASING FACTOR-1 (CRFR1) ANTAGONISTS TO REDUCE P-TAU AND IMPROVE THE COGNITION

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GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives

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BR9909739A (pt) 2001-03-20
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ID26156A (id) 2000-11-30
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