ES2160158T3 - Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas. - Google Patents

Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas.

Info

Publication number
ES2160158T3
ES2160158T3 ES95913377T ES95913377T ES2160158T3 ES 2160158 T3 ES2160158 T3 ES 2160158T3 ES 95913377 T ES95913377 T ES 95913377T ES 95913377 T ES95913377 T ES 95913377T ES 2160158 T3 ES2160158 T3 ES 2160158T3
Authority
ES
Spain
Prior art keywords
lower alkyl
represents hydrogen
testosterone
adrenergic receptors
reductasas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95913377T
Other languages
English (en)
Inventor
Kiyoshi Yoshida
Tadashi Kurimoto
Mineo Takei
Hiroki Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2160158T3 publication Critical patent/ES2160158T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN DERIVADO DE INDOL REPRESENTADO POR LA FORMULA (1) O UNA SAL DEL MISMO, Y UN PRODUCTO FARMACEUTICO QUE CONTIENE EL DERIVADO O LA SAL: [EN DONDE R{SUP,1} REPRESENTA UN ALQUILO INFERIOR;R{SUP,2} REPRESENTA HIDROGENO O FENILO QUE PUEDE ESTAR SUSTITUIDO POR AL MENOS UN ALQUILO INFERIOR, ALCOXI INFERIOR O UN ATOMO DE HALOGENO;R{SUP,3} REPRESENTA HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, O FENILALCOXI EL CUAL PUEDE SER SUSTITUIDO POR HALOGENO O ALQUILO INFERIOR;R{SUP,4} REPRESENTA HIDROGENO, ALQUILO INFERIOR, O ALCOXI INFERIOR; R{SUP,5} REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y N REPRESENTA UN ENTERO DE 1 A 5].ESTE COMPUESTO TIENE EL EFECTO DE BLOQUEAR RECEPTORES {AL}{SUB,1}ADRENERGICOS E INHIBIR REDUCTASAS 5{AL} DE TESTOSTERONA, Y ES UTIL COMO UN REMEDIO Y/O UNA PREVENTIVO PARA ENFERMEDADES CAUSADAS POR SOBREPRODUCCION DE DIHIDROTESTOSTERONA, TAL COMO LA HIPERTROFIA PROSTATICA, Y ENFERMEDADES ACOMPAÑANTES DE LA MISMA, TAL COMO TRASTORNOS DE LA ORINA, ALOPECIA TIPO MASCULINA, ACNE, Y SIMILARES.
ES95913377T 1994-03-30 1995-03-29 Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas. Expired - Lifetime ES2160158T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8262094 1994-03-30

Publications (1)

Publication Number Publication Date
ES2160158T3 true ES2160158T3 (es) 2001-11-01

Family

ID=13779508

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95913377T Expired - Lifetime ES2160158T3 (es) 1994-03-30 1995-03-29 Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas.

Country Status (14)

Country Link
US (1) US5760040A (es)
EP (1) EP0753511B1 (es)
KR (1) KR100349634B1 (es)
CN (1) CN1067985C (es)
AT (1) ATE203012T1 (es)
AU (1) AU681021B2 (es)
CA (1) CA2186499A1 (es)
DE (1) DE69521687T2 (es)
DK (1) DK0753511T3 (es)
ES (1) ES2160158T3 (es)
GR (1) GR3036735T3 (es)
PT (1) PT753511E (es)
UY (1) UY25970A1 (es)
WO (1) WO1995026955A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1135558A (ja) * 1997-07-18 1999-02-09 Zeria Pharmaceut Co Ltd ３−ベンゾイルインドール誘導体及びそれらを含有する医薬
EP1075486A1 (en) 1998-05-06 2001-02-14 Duke University Method of treating bladder and lower urinary tract syndromes
CN1307563A (zh) * 1998-06-30 2001-08-08 泽里新药工业株式会社 N－苯基－n′－苯丙基哌嗪衍生物及其制备方法
KR100368297B1 (ko) * 2000-05-31 2003-01-24 이승기 양성 전립선 비대증 치료용 메나퀴논 7
TWI317634B (en) * 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
US7528165B2 (en) * 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
US7632955B2 (en) * 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US20060135540A1 (en) * 2004-11-30 2006-06-22 Jack Lin PPAR active compounds
US7456289B2 (en) * 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
BRPI0615929A2 (pt) * 2005-09-07 2011-05-31 Plexxikon Inc compostos ativos de ppar, composição, kit e uso dos mesmos
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
CA2898610C (en) 2013-01-21 2021-01-19 Osaka University Phenoxyalkylamine compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2063756T3 (es) 1987-06-04 1995-01-16 Ono Pharmaceutical Co Derivados de acido benzoilaminofenoxibutanoico.
FR2632641B1 (fr) 1988-06-13 1990-10-12 Irceba ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif
FR2637596B1 (fr) 1988-10-11 1992-09-04 Irceba Methyl-4 ((aryl-4 piperazinyl-1)-2 ethyl)-5 thiazole et ses derives, leur procede de preparation et les medicaments en contenant
FR2658514B1 (fr) * 1990-02-19 1992-06-19 Irceba Nouveaux derives du methyl-4 thiazole, leurs procedes de preparation et les compositions pharmaceutiques en contenant.
GB9011335D0 (en) * 1990-05-21 1990-07-11 Fujisawa Pharmaceutical Co Indolebutyric acid derivatives and process for preparation thereof
GB9115951D0 (en) * 1991-07-24 1991-09-11 Pfizer Ltd Indoles
JPH07501790A (ja) * 1991-09-11 1995-02-23 藤沢薬品工業株式会社 ５−アルファレダクターゼ阻害剤としてのインドール誘導体
GB9204024D0 (en) * 1992-02-25 1992-04-08 Fujisawa Pharmaceutical Co Indole derivatives
EP0558245A1 (en) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
EP0675109A1 (en) * 1992-12-21 1995-10-04 Taisho Pharmaceutical Co. Ltd N-substituted indole derivative

Also Published As

Publication number Publication date
EP0753511B1 (en) 2001-07-11
EP0753511A1 (en) 1997-01-15
EP0753511A4 (en) 1997-07-23
CN1145617A (zh) 1997-03-19
UY25970A1 (es) 2001-08-27
DE69521687D1 (de) 2001-08-16
PT753511E (pt) 2001-11-30
KR970702273A (ko) 1997-05-13
GR3036735T3 (en) 2001-12-31
AU681021B2 (en) 1997-08-14
CN1067985C (zh) 2001-07-04
KR100349634B1 (ko) 2003-01-08
WO1995026955A1 (fr) 1995-10-12
CA2186499A1 (en) 1995-10-12
DK0753511T3 (da) 2001-09-24
AU2084195A (en) 1995-10-23
ATE203012T1 (de) 2001-07-15
DE69521687T2 (de) 2001-10-25
US5760040A (en) 1998-06-02

Similar Documents

Publication Publication Date Title
NO965305D0 (no) Nye forbindelser, fremgangsmåter ved deres fremstilling og anti-tumormidler
BR9909961A (pt) Derivados de cadeia lateral alquila e alquenila funcionalizados de glicinamidas como inibidores de farnesil transferase
ATE253545T1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
NO2012021I2 (no) Perampanel eller salter eller hydrater derav
EP1382604A4 (en) QUINOLINE DERIVATIVES HAVING AN AZOLYL GROUP AND QUINAZOLINE DERIVATIVES
ES2160158T3 (es) Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas.
EA200300982A1 (ru) Гетероциклические производные для лечения рака и других пролиферативных заболеваний
PT918776E (pt) Sintese total de acilfulvenos antitumorais
DE69931051D1 (de) Neue vinylbenzolderivate
EA200301317A1 (ru) Производные аминохинолина и его применение в качестве лигандов аденозина a3
ATE239741T1 (de) Derivate der phosphonsäure zur inhibierung von carboxypeptidase b
MEP12108A (en) Novel branched substituted amino derivatives of 3-amino-1-phenyl-1h[1,2,4]triazol, methods for producing them and pharmaceutical compositions containing them
EA200400656A1 (ru) Новые манделатные соли замещенных тетрациклических производных тетрагидрофурана
ID24566A (id) Obat untuk alopesia
DK0504290T3 (da) Inhibitorer af dihydrofylatreduktase fra Pneumocystis carinii
ID26809A (id) Senyawa-senyawa turunan sianoiminokuinoksalin
ATE259346T1 (de) Benflumentolderivative und ihre verwendung gegen parasitäre protozoen und trematoden
DK0580378T3 (da) Substituerede benzoatderivater

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 753511

Country of ref document: ES