DE69931051D1 - Neue vinylbenzolderivate - Google Patents

Neue vinylbenzolderivate

Info

Publication number
DE69931051D1
DE69931051D1 DE69931051T DE69931051T DE69931051D1 DE 69931051 D1 DE69931051 D1 DE 69931051D1 DE 69931051 T DE69931051 T DE 69931051T DE 69931051 T DE69931051 T DE 69931051T DE 69931051 D1 DE69931051 D1 DE 69931051D1
Authority
DE
Germany
Prior art keywords
lower alkyl
phenyl
vinylbenzole
derivatives
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69931051T
Other languages
English (en)
Inventor
Eiichi Shirasawa
Koji Konomi
Masaki Ichikawa
Hiroshi Suhara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69931051D1 publication Critical patent/DE69931051D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015Esters of acyclic unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/64Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66Methanesulfonates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/84Unsaturated compounds containing keto groups containing six membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/88Unsaturated compounds containing keto groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3826Acyclic unsaturated acids
DE69931051T 1998-05-25 1999-05-19 Neue vinylbenzolderivate Expired - Fee Related DE69931051D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14330798 1998-05-25
PCT/JP1999/002601 WO1999061403A1 (fr) 1998-05-25 1999-05-19 Nouveaux derives vinylbenzene

Publications (1)

Publication Number Publication Date
DE69931051D1 true DE69931051D1 (de) 2006-06-01

Family

ID=15335728

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69931051T Expired - Fee Related DE69931051D1 (de) 1998-05-25 1999-05-19 Neue vinylbenzolderivate

Country Status (5)

Country Link
US (1) US6329547B1 (de)
EP (1) EP1094055B1 (de)
AT (1) ATE324362T1 (de)
DE (1) DE69931051D1 (de)
WO (1) WO1999061403A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100865262B1 (ko) * 2001-04-11 2008-10-24 센주 세이야꾸 가부시키가이샤 시각 기능 장애 개선제
EP1616577B1 (de) * 2003-04-18 2011-09-21 Senju Pharmaceutical Co., Ltd. 2-Chloro-6,7-dimethoxy-N-5 [5-(1)H- indazolyl]quinazolin-4-amin, N-(1-Benzyl-4-piperidinyl)-1H-indazol-5-amin dihydrochlorid, 4-[2-(2,3,4,5,6-pentafluorophenyl)acryloyl]zimtsäure und Fasudil-Hydrochlorid zur Verwendung bei der Wiederherstellung der Hornhautwahrnehmung.
US20060135609A1 (en) 2004-10-21 2006-06-22 Duke University Ophthamological drugs
PL2107052T3 (pl) * 2006-12-26 2012-05-31 Santen Pharmaceutical Co Ltd Nowa pochodna N-(2-aminofenylo)benzamidu posiadająca strukturę mocznikową
ES2659980T3 (es) 2007-08-29 2018-03-20 Senju Pharmaceutical Co., Ltd. Agente para promover la adherencia de células endoteliales de la córnea
CA2858173C (en) 2011-12-06 2023-09-26 Advanced Cell Technology, Inc. Method of directed differentiation producing corneal endothelial cells, compositions thereof, and uses thereof
EP2799537B1 (de) 2011-12-28 2021-09-22 Kyoto Prefectural Public University Corporation Normalisierung der züchtung von hornhautendothelzellen
CN103739482B (zh) * 2012-06-29 2015-08-26 常州大学 酰基苯氧乙酸类化合物及其制备方法
JP6548576B2 (ja) 2013-07-30 2019-07-24 京都府公立大学法人 角膜内皮細胞マーカー
WO2015064768A1 (ja) 2013-10-31 2015-05-07 京都府公立大学法人 角膜内皮の小胞体細胞死関連疾患治療薬
US20190083543A1 (en) 2016-02-15 2019-03-21 Kyoto Prefectural Public University Corporation Human functional corneal endothelial cell and application thereof
WO2020045642A1 (ja) 2018-08-31 2020-03-05 学校法人同志社 眼細胞を保存または培養するための組成物および方法
WO2020071438A1 (ja) 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
BR112022017180A2 (pt) 2020-02-27 2022-10-18 Kyoto Prefectural Public Univ Corp Células endoteliais da córnea humanas funcionais e aplicação das mesmas
KR20240005837A (ko) 2021-05-03 2024-01-12 아스텔라스 인스티튜트 포 리제너러티브 메디슨 성숙한 각막 내피 세포의 생성 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6032048A (ja) * 1983-08-01 1985-02-19 Matsushita Electric Ind Co Ltd パタ−ン形成方法
WO1986007259A1 (en) * 1985-06-14 1986-12-18 Massachusetts Eye & Ear Infirmary Increasing aqueous humor outflow
US4757089A (en) 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
JPH0713013A (ja) 1993-06-29 1995-01-17 Casio Comput Co Ltd カラーフィルタとブラックマスクの形成方法
CA2250690A1 (en) 1996-03-29 1997-10-09 G.D. Searle & Co. Cinnamic acid derivatives and their use as integrin antagonists

Also Published As

Publication number Publication date
US6329547B1 (en) 2001-12-11
ATE324362T1 (de) 2006-05-15
EP1094055B1 (de) 2006-04-26
EP1094055A1 (de) 2001-04-25
WO1999061403A1 (fr) 1999-12-02
EP1094055A4 (de) 2005-03-02

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee