BR9909961A - Derivados de cadeia lateral alquila e alquenila funcionalizados de glicinamidas como inibidores de farnesil transferase - Google Patents
Derivados de cadeia lateral alquila e alquenila funcionalizados de glicinamidas como inibidores de farnesil transferaseInfo
- Publication number
- BR9909961A BR9909961A BR9909961-6A BR9909961A BR9909961A BR 9909961 A BR9909961 A BR 9909961A BR 9909961 A BR9909961 A BR 9909961A BR 9909961 A BR9909961 A BR 9909961A
- Authority
- BR
- Brazil
- Prior art keywords
- glycinamides
- alkyl
- transferase inhibitors
- farnesyl transferase
- functionalized derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE CADEIA LATERAL ALQUILA E ALQUENILA FUNCIONALIZADOS DE GLICINAMIDAS COMO INIBIDORES DE FARNESIL TRANSFERASE". A presente invenção propicia compostos de fórmula (I). A presente invenção providencia também um método para o tratamento do câncer e tratamento ou prevenção da restenose ou aterosclerose. Também providencia-se, por meio da presenta invenção, uma composição farmaceuticamente aceitável contendo um composto de Fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8325598P | 1998-04-27 | 1998-04-27 | |
PCT/US1999/006090 WO1999055725A1 (en) | 1998-04-27 | 1999-03-19 | Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909961A true BR9909961A (pt) | 2000-12-26 |
Family
ID=22177160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909961-6A BR9909961A (pt) | 1998-04-27 | 1999-03-19 | Derivados de cadeia lateral alquila e alquenila funcionalizados de glicinamidas como inibidores de farnesil transferase |
Country Status (15)
Country | Link |
---|---|
US (1) | US6369034B1 (pt) |
EP (1) | EP1076663B1 (pt) |
JP (1) | JP2002513031A (pt) |
KR (1) | KR20010043035A (pt) |
AT (1) | ATE259826T1 (pt) |
AU (1) | AU759492B2 (pt) |
BR (1) | BR9909961A (pt) |
CA (1) | CA2322944C (pt) |
DE (1) | DE69914893T2 (pt) |
DK (1) | DK1076663T3 (pt) |
ES (1) | ES2214021T3 (pt) |
NZ (1) | NZ507165A (pt) |
PT (1) | PT1076663E (pt) |
WO (1) | WO1999055725A1 (pt) |
ZA (1) | ZA200006035B (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2478500A (en) | 1998-12-08 | 2000-06-26 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US6284755B1 (en) | 1998-12-08 | 2001-09-04 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
EP1539234A4 (en) * | 2002-09-05 | 2006-02-15 | Medimmune Inc | METHODS OF PREVENTING OR TREATING CELLULAR MALIGNITES BY ADMINISTERING CD2 ANTAGONISTS |
US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
JP3837633B2 (ja) * | 2002-11-19 | 2006-10-25 | 株式会社クレディアジャパン | 新規な機能性ペプチド核酸およびその製法 |
EP2316487B1 (en) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
DE10326303A1 (de) * | 2003-06-11 | 2004-12-30 | Celares Gmbh | Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung |
US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
JP4934426B2 (ja) | 2003-08-18 | 2012-05-16 | メディミューン,エルエルシー | 抗体のヒト化 |
EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
JP5153613B2 (ja) | 2005-03-18 | 2013-02-27 | メディミューン,エルエルシー | 抗体のフレームワーク・シャッフル |
US8987306B2 (en) * | 2005-06-07 | 2015-03-24 | The Trustees Of The University Of Pennsylvania | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold |
JP2008542445A (ja) * | 2005-06-07 | 2008-11-27 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | α2β1/GPIa−IIaインテグリン阻害剤 |
KR20080025174A (ko) | 2005-06-23 | 2008-03-19 | 메디뮨 인코포레이티드 | 응집 및 단편화 프로파일이 최적화된 항체 제제 |
WO2007027742A2 (en) * | 2005-08-31 | 2007-03-08 | The Trustees Of The University Of Pennsylvania | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS |
JP5209625B2 (ja) | 2006-08-28 | 2013-06-12 | 協和発酵キリン株式会社 | アンタゴニストのヒトlight特異的ヒトモノクローナル抗体 |
AU2008232902B2 (en) | 2007-03-30 | 2013-10-03 | Medlmmune, Llc | Antibody formulation |
KR101686247B1 (ko) | 2007-10-31 | 2016-12-14 | 메디뮨 엘엘씨 | 단백질 스캐폴드 |
DK2668210T3 (da) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
CN116574185A (zh) | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
SG11201509982UA (pt) | 2013-06-06 | 2016-04-28 | Igenica Biotherapeutics Inc | |
DK3041507T3 (da) | 2013-08-26 | 2021-07-26 | Biontech Res And Development Inc | Nukleinsyrer, der koder for humane antistoffer mod sialyl-lewis a |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
KR102614642B1 (ko) | 2014-06-04 | 2023-12-19 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | 강글리오사이드 gd2에 대한 사람 단클론 항체 |
PT3333191T (pt) | 2014-12-11 | 2020-12-15 | Pf Medicament | Anticorpos anti-c10orf54 e suas utilizações |
BR112017015880A2 (pt) | 2015-03-03 | 2018-07-31 | Kymab Ltd | anticorpos, usos e métodos |
KR20180100122A (ko) | 2015-12-02 | 2018-09-07 | 주식회사 에스티사이언스 | 당화된 btla(b- 및 t-림프구 약화인자)에 특이적인 항체 |
EP3909983A1 (en) | 2015-12-02 | 2021-11-17 | STCube & Co. Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
CN111051346A (zh) | 2017-05-31 | 2020-04-21 | 斯特库伯株式会社 | 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法 |
KR20200015602A (ko) | 2017-05-31 | 2020-02-12 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도 |
EP3635007A1 (en) | 2017-06-06 | 2020-04-15 | STCube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands |
US11707522B2 (en) | 2017-10-13 | 2023-07-25 | Boehringer Ingelheim International Gmbh | Human antibodies to Tn antigen |
EP3824287A1 (en) | 2018-07-20 | 2021-05-26 | Pierre Fabre Médicament | Receptor for vista |
WO2022020651A1 (en) * | 2020-07-22 | 2022-01-27 | Fog Pharmaceuticals, Inc. | Amino acids |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5576293A (en) | 1993-09-30 | 1996-11-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
KR100362338B1 (ko) * | 1993-11-05 | 2003-04-08 | 워너-램버트 캄파니 | 단백질:파르네실트랜스퍼라아제의치환디-및트리펩티드억제제 |
US5571792A (en) | 1994-06-30 | 1996-11-05 | Warner-Lambert Company | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
CA2253934A1 (en) | 1996-05-22 | 1997-11-27 | Warner-Lambert Company | Inhibitors of protein farnesyl transferase |
WO1998027109A1 (en) | 1996-12-17 | 1998-06-25 | Warner-Lambert Company | Cycloalkyl inhibitors of protein farnesyltransferase |
US6265382B1 (en) | 1997-04-11 | 2001-07-24 | Warner-Lambert Company | Dipeptide inhibitors of protein farnesyltransferase |
-
1999
- 1999-03-19 DE DE69914893T patent/DE69914893T2/de not_active Expired - Fee Related
- 1999-03-19 BR BR9909961-6A patent/BR9909961A/pt not_active IP Right Cessation
- 1999-03-19 PT PT99914958T patent/PT1076663E/pt unknown
- 1999-03-19 EP EP99914958A patent/EP1076663B1/en not_active Expired - Lifetime
- 1999-03-19 WO PCT/US1999/006090 patent/WO1999055725A1/en not_active Application Discontinuation
- 1999-03-19 AT AT99914958T patent/ATE259826T1/de not_active IP Right Cessation
- 1999-03-19 CA CA002322944A patent/CA2322944C/en not_active Expired - Fee Related
- 1999-03-19 KR KR1020007011897A patent/KR20010043035A/ko not_active Application Discontinuation
- 1999-03-19 AU AU33587/99A patent/AU759492B2/en not_active Ceased
- 1999-03-19 DK DK99914958T patent/DK1076663T3/da active
- 1999-03-19 US US09/646,147 patent/US6369034B1/en not_active Expired - Fee Related
- 1999-03-19 JP JP2000545883A patent/JP2002513031A/ja active Pending
- 1999-03-19 NZ NZ507165A patent/NZ507165A/xx unknown
- 1999-03-19 ES ES99914958T patent/ES2214021T3/es not_active Expired - Lifetime
-
2000
- 2000-10-26 ZA ZA200006035A patent/ZA200006035B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK1076663T3 (da) | 2004-06-01 |
AU759492B2 (en) | 2003-04-17 |
CA2322944A1 (en) | 1999-11-04 |
JP2002513031A (ja) | 2002-05-08 |
ES2214021T3 (es) | 2004-09-01 |
AU3358799A (en) | 1999-11-16 |
DE69914893T2 (de) | 2004-07-22 |
DE69914893D1 (de) | 2004-03-25 |
EP1076663A1 (en) | 2001-02-21 |
KR20010043035A (ko) | 2001-05-25 |
PT1076663E (pt) | 2004-06-30 |
NZ507165A (en) | 2003-06-30 |
ATE259826T1 (de) | 2004-03-15 |
WO1999055725A1 (en) | 1999-11-04 |
CA2322944C (en) | 2003-05-20 |
ZA200006035B (en) | 2002-01-28 |
US6369034B1 (en) | 2002-04-09 |
EP1076663B1 (en) | 2004-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1975 DE 11/11/2008. |