ES2097653T3 - Nuevos derivados de desoxigalactonojirimicina. - Google Patents
Nuevos derivados de desoxigalactonojirimicina.Info
- Publication number
- ES2097653T3 ES2097653T3 ES94916021T ES94916021T ES2097653T3 ES 2097653 T3 ES2097653 T3 ES 2097653T3 ES 94916021 T ES94916021 T ES 94916021T ES 94916021 T ES94916021 T ES 94916021T ES 2097653 T3 ES2097653 T3 ES 2097653T3
- Authority
- ES
- Spain
- Prior art keywords
- deoxygalactonojirimicina
- new derivatives
- novel
- derivatives
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/131—Amines acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE PROPORCIONAN UNOS NUEVOS DERIVADOS N-ALQUILO DEOXIGALACTONOJIRIMICINA EN LOS QUE EL CITADO ALQUILO CONTIENE DE 3 A 6 ATOMOS DE CARBONO. ESTOS NUEVAS COMPOSICIONES SON UTILES PARA LA INHIBICION SELECTIVA DE GLUCOLIPIDOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/061,645 US5399567A (en) | 1993-05-13 | 1993-05-13 | Method of treating cholera |
US08/102,654 US6291657B1 (en) | 1993-05-13 | 1993-08-05 | Deoxygalactonojirimycin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097653T3 true ES2097653T3 (es) | 1997-04-01 |
Family
ID=26741316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94916021T Expired - Lifetime ES2097653T3 (es) | 1993-05-13 | 1994-05-11 | Nuevos derivados de desoxigalactonojirimicina. |
Country Status (11)
Country | Link |
---|---|
US (3) | US6291657B1 (es) |
EP (1) | EP0698012B1 (es) |
JP (1) | JP3636363B2 (es) |
AT (1) | ATE148456T1 (es) |
AU (1) | AU6783294A (es) |
CA (1) | CA2159988C (es) |
DE (1) | DE69401658T2 (es) |
DK (1) | DK0698012T3 (es) |
ES (1) | ES2097653T3 (es) |
GR (1) | GR3022554T3 (es) |
WO (1) | WO1994026714A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
AU1734600A (en) * | 1998-11-17 | 2000-06-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Identification of glycosphingolipids that promote hiv-1 entry into cells |
US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
AU6050600A (en) | 1999-07-26 | 2001-02-13 | G.D. Searle & Co. | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases |
EP1210082B1 (en) * | 1999-08-10 | 2008-01-02 | The Chancellor, Masters And Scholars Of The University Of Oxford | Long chain n-alkyl compounds and oxa-derivatives thereof and use as antiviral compositions |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
US7985760B2 (en) | 2002-07-17 | 2011-07-26 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase |
EP1554245B1 (en) | 2002-07-17 | 2012-09-26 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
GB0229476D0 (en) * | 2002-12-17 | 2003-01-22 | Oxford Glycosciences Uk Ltd | Novel process |
CA2814767C (en) | 2003-01-31 | 2016-03-15 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
US7741340B2 (en) * | 2003-11-12 | 2010-06-22 | Amicus Therapeutics, Inc. | Hydroxy piperidine derivatives to treat gaucher disease |
US20050256168A1 (en) * | 2004-04-28 | 2005-11-17 | Block Timothy M | Compositions for oral administration for the treatment of interferon-responsive disorders |
US20090111812A1 (en) * | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
CA2612538C (en) | 2005-05-17 | 2015-06-30 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
EP2356990A3 (en) * | 2006-08-02 | 2011-10-19 | University of Oxford | Liposome treatment of viral infections |
JP2011518124A (ja) * | 2008-03-26 | 2011-06-23 | ユニバーシティ・オブ・オックスフォード | 小胞体ターゲッティングリポソーム |
WO2010111711A2 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
US8703744B2 (en) * | 2009-03-27 | 2014-04-22 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
PL2655388T3 (pl) | 2010-12-23 | 2016-12-30 | Selektywne inhibitory glikozydazy i ich zastosowania | |
US9718854B2 (en) | 2011-03-31 | 2017-08-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
WO2013000086A1 (en) | 2011-06-27 | 2013-01-03 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
EP2890675A4 (en) | 2012-08-31 | 2016-01-13 | Alectos Therapeutics Inc | GLYCOSIDASE INHIBITORS AND USES THEREOF |
EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
WO2014032187A1 (en) * | 2012-08-31 | 2014-03-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
BR112015009638A2 (pt) | 2012-10-31 | 2017-07-04 | Alectos Therapeutics Inc | inibidores de glicosidase e usos dos mesmos |
US9827189B2 (en) | 2013-01-09 | 2017-11-28 | Amicus Therapeautics, Inc. | Stable parenteral DNJ compositions |
CN110799497A (zh) * | 2017-06-01 | 2020-02-14 | 爱杜西亚药品有限公司 | N-丁基脱氧半乳糖野尻霉素的结晶型 |
US20220411371A1 (en) | 2019-09-25 | 2022-12-29 | Teva Pharmaceuticals International Gmbh | Solid state forms of lucerastat and process for preparation thereof |
WO2022132992A1 (en) | 2020-12-16 | 2022-06-23 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds |
US11623916B2 (en) | 2020-12-16 | 2023-04-11 | Amicus Therapeutics, Inc. | Highly purified batches of pharmaceutical grade migalastat and methods of producing the same |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
JPS63501925A (ja) | 1985-12-23 | 1988-08-04 | フレツド ハツチンソン キヤンサ− リサ−チ センタ− | レトロウイルスの複製、感染及び疾病誘発の制御 |
US4849430A (en) | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
US5030638A (en) | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
CA2086413A1 (en) | 1990-06-29 | 1991-12-30 | Yohji Ezure | Piperidine derivatives |
US5128347A (en) * | 1990-10-18 | 1992-07-07 | Monsanto Company | Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin |
-
1993
- 1993-08-05 US US08/102,654 patent/US6291657B1/en not_active Expired - Lifetime
-
1994
- 1994-05-11 AU AU67832/94A patent/AU6783294A/en not_active Abandoned
- 1994-05-11 JP JP52554194A patent/JP3636363B2/ja not_active Expired - Fee Related
- 1994-05-11 WO PCT/US1994/004974 patent/WO1994026714A1/en active IP Right Grant
- 1994-05-11 AT AT94916021T patent/ATE148456T1/de not_active IP Right Cessation
- 1994-05-11 EP EP94916021A patent/EP0698012B1/en not_active Expired - Lifetime
- 1994-05-11 DK DK94916021.2T patent/DK0698012T3/da active
- 1994-05-11 DE DE69401658T patent/DE69401658T2/de not_active Expired - Fee Related
- 1994-05-11 CA CA002159988A patent/CA2159988C/en not_active Expired - Fee Related
- 1994-05-11 ES ES94916021T patent/ES2097653T3/es not_active Expired - Lifetime
-
1995
- 1995-03-01 US US08/396,989 patent/US5580884A/en not_active Expired - Lifetime
-
1996
- 1996-01-17 US US08/588,027 patent/US5786368A/en not_active Expired - Fee Related
-
1997
- 1997-02-12 GR GR970400244T patent/GR3022554T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US6291657B1 (en) | 2001-09-18 |
ATE148456T1 (de) | 1997-02-15 |
GR3022554T3 (en) | 1997-05-31 |
DE69401658D1 (de) | 1997-03-13 |
DK0698012T3 (es) | 1997-02-17 |
CA2159988C (en) | 2007-01-09 |
US5786368A (en) | 1998-07-28 |
JP3636363B2 (ja) | 2005-04-06 |
CA2159988A1 (en) | 1994-11-24 |
EP0698012A1 (en) | 1996-02-28 |
DE69401658T2 (de) | 1997-06-12 |
EP0698012B1 (en) | 1997-01-29 |
US5580884A (en) | 1996-12-03 |
AU6783294A (en) | 1994-12-12 |
JPH08510244A (ja) | 1996-10-29 |
WO1994026714A1 (en) | 1994-11-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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