UY25970A1 - Derivado de indol para tratamiento de superproducción de dihidrotestosterona - Google Patents

Derivado de indol para tratamiento de superproducción de dihidrotestosterona

Info

Publication number
UY25970A1
UY25970A1 UY25970A UY25970A UY25970A1 UY 25970 A1 UY25970 A1 UY 25970A1 UY 25970 A UY25970 A UY 25970A UY 25970 A UY25970 A UY 25970A UY 25970 A1 UY25970 A1 UY 25970A1
Authority
UY
Uruguay
Prior art keywords
lower alkyl
represents hydrogen
dihydrotestosterone
overproduction
substituted
Prior art date
Application number
UY25970A
Other languages
English (en)
Inventor
Kiyoshi Yoshida
Tadashi Kurimoto
Mineo Takei
Hiroki Sato
Original Assignee
Zeria Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharm Co Ltd filed Critical Zeria Pharm Co Ltd
Publication of UY25970A1 publication Critical patent/UY25970A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivado de indol representado por la fórmula (I) o una sal del mismo, y un compuesto farmacéutico que contenga el derivado o la sal: en la cual R1 representa alquilo inferior; R2 representa hidrógeno o fenilo que puede estar sustituido por al menos un alquilo inferior, un alcoxi inferior o un átomo de halógeno; R3 representa hidrógeno, alquilo inferior, alcoxi inferior o fenilalquiloxi que puede estar sustituido por halógeno o alquilo inferior; R4 representa hidrógeno o alquilo inferior; y n representa un número entero de 1 a 5. Este compuesto tiene el efecto de bloquear los receptores a(alfa)1-adrenérgicos e inhibir las testosteronas 5a(alfa)-reductasas, y es útil para el remedio y/o prevención de enfermedades causadas por superproducción de dihidrotestosterona, como por ejemplo hipertrofia de la próstata y padecimientos que acompanan la misma, como por ejemplo trastornos urinarios, alopecia y acné. Ej. no limitante: 4-{3-{3-metoxi-4-{1-(4-metilfenil)-3-[4-(2-metoxifenil)piperazin-1-il]propoxi}benzoil}indol-1-il}butanoato de potasio.
UY25970A 1994-03-30 2000-01-17 Derivado de indol para tratamiento de superproducción de dihidrotestosterona UY25970A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8262094 1994-03-30
PCT/JP1995/000599 WO1995026955A1 (fr) 1994-03-30 1995-03-29 Derive d'indole et medicament le contenant

Publications (1)

Publication Number Publication Date
UY25970A1 true UY25970A1 (es) 2001-08-27

Family

ID=13779508

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25970A UY25970A1 (es) 1994-03-30 2000-01-17 Derivado de indol para tratamiento de superproducción de dihidrotestosterona

Country Status (14)

Country Link
US (1) US5760040A (es)
EP (1) EP0753511B1 (es)
KR (1) KR100349634B1 (es)
CN (1) CN1067985C (es)
AT (1) ATE203012T1 (es)
AU (1) AU681021B2 (es)
CA (1) CA2186499A1 (es)
DE (1) DE69521687T2 (es)
DK (1) DK0753511T3 (es)
ES (1) ES2160158T3 (es)
GR (1) GR3036735T3 (es)
PT (1) PT753511E (es)
UY (1) UY25970A1 (es)
WO (1) WO1995026955A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1135558A (ja) * 1997-07-18 1999-02-09 Zeria Pharmaceut Co Ltd ３−ベンゾイルインドール誘導体及びそれらを含有する医薬
EP1075486A1 (en) 1998-05-06 2001-02-14 Duke University Method of treating bladder and lower urinary tract syndromes
CN1307563A (zh) * 1998-06-30 2001-08-08 泽里新药工业株式会社 N－苯基－n′－苯丙基哌嗪衍生物及其制备方法
KR100368297B1 (ko) * 2000-05-31 2003-01-24 이승기 양성 전립선 비대증 치료용 메나퀴논 7
US6933316B2 (en) * 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
US7632955B2 (en) * 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US7528165B2 (en) * 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
EP1833787A2 (en) * 2004-11-30 2007-09-19 Plexxikon, Inc. Indole derivatives for use as ppar active compounds
US7456289B2 (en) * 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
CA2621474A1 (en) * 2005-09-07 2007-03-15 Plexxikon, Inc. 1,3-disubstituted indole derivatives for use as ppar modulators
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
ES2700527T3 (es) 2013-01-21 2019-02-18 Univ Osaka Compuesto de fenoxialquilamina

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935240A (en) 1987-06-04 1990-06-19 Ono Pharmaceutical Co., Ltd. Benzoylaminophenoxybutanoic acid derivatives
FR2632641B1 (fr) 1988-06-13 1990-10-12 Irceba ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif
FR2637596B1 (fr) 1988-10-11 1992-09-04 Irceba Methyl-4 ((aryl-4 piperazinyl-1)-2 ethyl)-5 thiazole et ses derives, leur procede de preparation et les medicaments en contenant
FR2658514B1 (fr) * 1990-02-19 1992-06-19 Irceba Nouveaux derives du methyl-4 thiazole, leurs procedes de preparation et les compositions pharmaceutiques en contenant.
GB9011335D0 (en) 1990-05-21 1990-07-11 Fujisawa Pharmaceutical Co Indolebutyric acid derivatives and process for preparation thereof
GB9115951D0 (en) 1991-07-24 1991-09-11 Pfizer Ltd Indoles
CA2118697A1 (en) * 1991-09-11 1993-03-18 Satoshi Okada Indole derivatives as 5-alpha-reductase inhibitor
GB9204024D0 (en) * 1992-02-25 1992-04-08 Fujisawa Pharmaceutical Co Indole derivatives
EP0558245A1 (en) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
EP0675109A1 (en) * 1992-12-21 1995-10-04 Taisho Pharmaceutical Co. Ltd N-substituted indole derivative

Also Published As

Publication number Publication date
EP0753511A4 (en) 1997-07-23
EP0753511B1 (en) 2001-07-11
AU2084195A (en) 1995-10-23
DK0753511T3 (da) 2001-09-24
DE69521687D1 (de) 2001-08-16
GR3036735T3 (en) 2001-12-31
DE69521687T2 (de) 2001-10-25
EP0753511A1 (en) 1997-01-15
KR970702273A (ko) 1997-05-13
CA2186499A1 (en) 1995-10-12
ES2160158T3 (es) 2001-11-01
CN1067985C (zh) 2001-07-04
US5760040A (en) 1998-06-02
PT753511E (pt) 2001-11-30
CN1145617A (zh) 1997-03-19
KR100349634B1 (ko) 2003-01-08
WO1995026955A1 (fr) 1995-10-12
ATE203012T1 (de) 2001-07-15
AU681021B2 (en) 1997-08-14

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Legal Events

Date Code Title Description
ABAN Application deemed to be withdrawn (no publication fee paid)

Effective date: 20081218