EA200400656A1 - Новые манделатные соли замещенных тетрациклических производных тетрагидрофурана - Google Patents
Новые манделатные соли замещенных тетрациклических производных тетрагидрофуранаInfo
- Publication number
- EA200400656A1 EA200400656A1 EA200400656A EA200400656A EA200400656A1 EA 200400656 A1 EA200400656 A1 EA 200400656A1 EA 200400656 A EA200400656 A EA 200400656A EA 200400656 A EA200400656 A EA 200400656A EA 200400656 A1 EA200400656 A1 EA 200400656A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- mandelate
- new
- salts
- salts according
- mandelate salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Целью настоящего изобретения является новая манделатная соль замещенного тетрациклического производного тетрагидрофурана формулы (I), его N-оксидных форм и стереохимически изомерных форм, где каждый из Rи Rнезависимо представляет собой водород или Cалкил и каждый из Rи Rнезависимо представляет собой водород или галоген. В приведенных выше определениях Cалкил обозначает линейные или разветвленные насыщенные углеводородные радикалы, имеющие от 1 до 6 атомов углерода, такие как метил, этил, пропил, бутил, 1-метилпропил, 1,1-диметилэтил, пентил или гексил. Новая манделатная соль не чувствительна к свету и является гораздо более стабильной по сравнению с солями предшествующего уровня техники при комнатной температуре, повышенной температуре, при относительно высокой влажности и в водной среде. Также описываются фармацевтические композиции, включающие манделатные соли по изобретению, манделатные соли по изобретению для использования в качестве лекарственного препарата, способ получения манделатных солей по изобретению и использование манделатных солей и фармацевтических композиций, включающих манделатные соли по изобретению, для лечения или профилактики заболеваний ЦНС, сердечно-сосудистых заболеваний и желудочно-кишечных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204465 | 2001-11-09 | ||
| PCT/EP2002/011136 WO2003040122A1 (en) | 2001-11-09 | 2002-11-08 | Novel mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200400656A1 true EA200400656A1 (ru) | 2004-10-28 |
| EA006980B1 EA006980B1 (ru) | 2006-06-30 |
Family
ID=8181272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400656A EA006980B1 (ru) | 2001-11-09 | 2002-11-08 | Новые манделатные соли замещенных тетрациклических производных тетрагидрофурана |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7317115B2 (ru) |
| EP (1) | EP1446397B1 (ru) |
| JP (1) | JP2005508988A (ru) |
| KR (1) | KR100962325B1 (ru) |
| CN (1) | CN1582282B (ru) |
| AR (1) | AR037285A1 (ru) |
| AT (1) | ATE299138T1 (ru) |
| AU (1) | AU2002349327B2 (ru) |
| BR (1) | BR0212770A (ru) |
| CA (1) | CA2465043C (ru) |
| DE (1) | DE60204982T2 (ru) |
| EA (1) | EA006980B1 (ru) |
| ES (1) | ES2244818T3 (ru) |
| HR (1) | HRP20040395A2 (ru) |
| HU (1) | HUP0402224A3 (ru) |
| IL (2) | IL161866A0 (ru) |
| MX (1) | MXPA04004365A (ru) |
| MY (1) | MY128237A (ru) |
| NO (1) | NO328548B1 (ru) |
| NZ (1) | NZ531739A (ru) |
| PL (1) | PL368456A1 (ru) |
| TW (1) | TW200407117A (ru) |
| UA (1) | UA79248C2 (ru) |
| WO (1) | WO2003040122A1 (ru) |
| ZA (1) | ZA200403454B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2468038C (en) * | 2001-12-07 | 2011-04-26 | Janssen Pharmaceutica Nv | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
| WO2005013969A1 (en) * | 2003-07-15 | 2005-02-17 | Janssen Pharmaceutica N.V. | Antipsychotic agent with socializing properties |
| JP4912320B2 (ja) | 2004-12-07 | 2012-04-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換された四環式テトラヒドロピラン、ピロリジンおよびテトラヒドロチオフェン誘導体 |
| AU2006209397B2 (en) | 2005-01-27 | 2011-04-07 | Janssen Pharmaceutica N.V. | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT2 inhibitors in the treatment of CNS disorders |
| EA014104B1 (ru) | 2005-06-17 | 2010-10-29 | Янссен Фармацевтика Н.В. | Новые тетрациклические производные тетрагидрофурана, содержащие боковую цепь циклического амина |
| US8507040B2 (en) | 2008-05-08 | 2013-08-13 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8765223B2 (en) * | 2008-05-08 | 2014-07-01 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644462A1 (de) * | 1986-12-24 | 1988-07-07 | Basf Ag | Verfahren zur herstellung von 5h-dibenzo(a,d)cyclohepten-5-onen |
| JP2656720B2 (ja) * | 1992-12-09 | 1997-09-24 | 武田薬品工業株式会社 | 光学活性アミノクマラン誘導体 |
| DE69521122T2 (de) * | 1994-03-16 | 2002-03-07 | Cenes Ltd | 2,3,4,5-tetrahydro-1h-3-benzazepin säure-additions-salze |
| PL190960B1 (pl) * | 1996-04-12 | 2006-02-28 | Janssen Pharmaceutica Nv | Tetracykliczna pochodna tetrahydrofuranu, kompozycja farmaceutyczna i sposób wytwarzania tetracyklicznej pochodnej tetrahydrofuranu |
| WO1997044014A1 (en) | 1996-05-20 | 1997-11-27 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
| UA52778C2 (ru) | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозамещенные тетрациклические производные тетрагидрофурана, способ их получения и композиции на их основе |
| US6281247B1 (en) * | 1998-03-03 | 2001-08-28 | Novo Nordisk A/S | Salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)amide |
| HUP9904624A2 (hu) * | 1999-12-17 | 2002-01-28 | Sanofi-Synthelabo | Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| EP1186303A3 (en) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist |
-
2002
- 2002-08-11 UA UA20040604168A patent/UA79248C2/uk unknown
- 2002-11-07 MY MYPI20024166A patent/MY128237A/en unknown
- 2002-11-08 DE DE60204982T patent/DE60204982T2/de not_active Expired - Lifetime
- 2002-11-08 US US10/491,799 patent/US7317115B2/en not_active Expired - Fee Related
- 2002-11-08 AR ARP020104298A patent/AR037285A1/es unknown
- 2002-11-08 AT AT02781214T patent/ATE299138T1/de not_active IP Right Cessation
- 2002-11-08 KR KR1020047002379A patent/KR100962325B1/ko not_active IP Right Cessation
- 2002-11-08 CN CN02821918XA patent/CN1582282B/zh not_active Expired - Fee Related
- 2002-11-08 EP EP02781214A patent/EP1446397B1/en not_active Expired - Lifetime
- 2002-11-08 AU AU2002349327A patent/AU2002349327B2/en not_active Ceased
- 2002-11-08 EA EA200400656A patent/EA006980B1/ru not_active IP Right Cessation
- 2002-11-08 NZ NZ531739A patent/NZ531739A/en not_active IP Right Cessation
- 2002-11-08 PL PL02368456A patent/PL368456A1/xx unknown
- 2002-11-08 ES ES02781214T patent/ES2244818T3/es not_active Expired - Lifetime
- 2002-11-08 MX MXPA04004365A patent/MXPA04004365A/es active IP Right Grant
- 2002-11-08 TW TW091132840A patent/TW200407117A/zh unknown
- 2002-11-08 BR BR0212770-9A patent/BR0212770A/pt not_active IP Right Cessation
- 2002-11-08 IL IL16186602A patent/IL161866A0/xx unknown
- 2002-11-08 JP JP2003542168A patent/JP2005508988A/ja active Pending
- 2002-11-08 HU HU0402224A patent/HUP0402224A3/hu unknown
- 2002-11-08 CA CA2465043A patent/CA2465043C/en not_active Expired - Fee Related
- 2002-11-08 WO PCT/EP2002/011136 patent/WO2003040122A1/en active IP Right Grant
-
2004
- 2004-05-05 NO NO20041848A patent/NO328548B1/no not_active IP Right Cessation
- 2004-05-05 HR HR20040395A patent/HRP20040395A2/hr not_active Application Discontinuation
- 2004-05-06 IL IL161866A patent/IL161866A/en not_active IP Right Cessation
- 2004-05-06 ZA ZA200403454A patent/ZA200403454B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0402224A3 (en) | 2007-05-29 |
| ZA200403454B (en) | 2005-08-31 |
| KR20050044310A (ko) | 2005-05-12 |
| ATE299138T1 (de) | 2005-07-15 |
| AR037285A1 (es) | 2004-11-03 |
| KR100962325B1 (ko) | 2010-06-11 |
| DE60204982T2 (de) | 2006-04-27 |
| NO328548B1 (no) | 2010-03-15 |
| CN1582282A (zh) | 2005-02-16 |
| US20050085533A1 (en) | 2005-04-21 |
| NO20041848L (no) | 2004-05-05 |
| EA006980B1 (ru) | 2006-06-30 |
| HRP20040395A2 (en) | 2005-04-30 |
| NZ531739A (en) | 2005-02-25 |
| CN1582282B (zh) | 2012-06-06 |
| BR0212770A (pt) | 2004-10-13 |
| CA2465043C (en) | 2011-02-15 |
| US7317115B2 (en) | 2008-01-08 |
| IL161866A0 (en) | 2005-11-20 |
| ES2244818T3 (es) | 2005-12-16 |
| AU2002349327B2 (en) | 2008-10-23 |
| MXPA04004365A (es) | 2004-08-11 |
| DE60204982D1 (de) | 2005-08-11 |
| PL368456A1 (en) | 2005-03-21 |
| HUP0402224A2 (hu) | 2005-02-28 |
| CA2465043A1 (en) | 2003-05-15 |
| JP2005508988A (ja) | 2005-04-07 |
| MY128237A (en) | 2007-01-31 |
| WO2003040122A1 (en) | 2003-05-15 |
| IL161866A (en) | 2010-04-29 |
| TW200407117A (en) | 2004-05-16 |
| UA79248C2 (en) | 2007-06-11 |
| EP1446397A1 (en) | 2004-08-18 |
| EP1446397B1 (en) | 2005-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |