MXPA04004365A - Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido. - Google Patents
Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido.Info
- Publication number
- MXPA04004365A MXPA04004365A MXPA04004365A MXPA04004365A MXPA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A MX PA04004365 A MXPA04004365 A MX PA04004365A
- Authority
- MX
- Mexico
- Prior art keywords
- mandelate
- mandelate salts
- novel
- salts according
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
El objetivo de la presente invencion es presentar una novedosa sal mandelato de un derivado de tetrahidrofurano tetraciclico sustituido de acuerdo con la formula (I) ver formula (I) las formas de N-oxido y las formas estereoquimicamente isomericas de los mismos, en los cuales cada uno de R1 y R2 es independientemente hidrogeno o alquilo C1-C6 y cada uno de R3 y R4 es independientemente hidrogeno o halogeno; en las definiciones que anteceden, alquilo C1-C6 define radicales hidrocarburo de cadena recta o ramificada con 1 a 6 atomos de carbono tales como, por ejemplo, metilo, etilo, propilo, butilo, 1-metilpropilo, 1,1-dimetiletilo, pentilo y hexilo; la novedosa sal mandelato no es fotosensible y es mucho mas estable que las sales de la tecnica anterior a temperatura ambiente, a temperatura incrementada y a humedades relativas elevadas, asi como en medios acuosos; tambien se describen composiciones farmaceuticas que comprenden las sales mandelato de acuerdo con la presente invencion, las sales madelato de acuerdo con la presente invencion para usar como medicamento, un procedimiento para la preparacion de las sales mandelato de acuerdo con la presente invencion y el uso de las sales mandelato y composiciones farmaceuticas que comprende sales mandelato de acuerdo con la invencion para el tratamiento o la prevencion de trastornos del SNC, trastornos cardiovasculares y trastornos gastrointestinales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204465 | 2001-11-09 | ||
| PCT/EP2002/011136 WO2003040122A1 (en) | 2001-11-09 | 2002-11-08 | Novel mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04004365A true MXPA04004365A (es) | 2004-08-11 |
Family
ID=8181272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04004365A MXPA04004365A (es) | 2001-11-09 | 2002-11-08 | Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7317115B2 (es) |
| EP (1) | EP1446397B1 (es) |
| JP (1) | JP2005508988A (es) |
| KR (1) | KR100962325B1 (es) |
| CN (1) | CN1582282B (es) |
| AR (1) | AR037285A1 (es) |
| AT (1) | ATE299138T1 (es) |
| AU (1) | AU2002349327B2 (es) |
| BR (1) | BR0212770A (es) |
| CA (1) | CA2465043C (es) |
| DE (1) | DE60204982T2 (es) |
| EA (1) | EA006980B1 (es) |
| ES (1) | ES2244818T3 (es) |
| HR (1) | HRP20040395A2 (es) |
| HU (1) | HUP0402224A3 (es) |
| IL (2) | IL161866A0 (es) |
| MX (1) | MXPA04004365A (es) |
| MY (1) | MY128237A (es) |
| NO (1) | NO328548B1 (es) |
| NZ (1) | NZ531739A (es) |
| PL (1) | PL368456A1 (es) |
| TW (1) | TW200407117A (es) |
| UA (1) | UA79248C2 (es) |
| WO (1) | WO2003040122A1 (es) |
| ZA (1) | ZA200403454B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60203937T2 (de) * | 2001-12-07 | 2006-05-11 | Janssen Pharmaceutica N.V. | Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten |
| WO2005013969A1 (en) * | 2003-07-15 | 2005-02-17 | Janssen Pharmaceutica N.V. | Antipsychotic agent with socializing properties |
| RU2401257C2 (ru) | 2004-12-07 | 2010-10-10 | Янссен Фармацевтика Н.В. | Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена |
| MX2007009092A (es) | 2005-01-27 | 2007-09-12 | Janssen Pharmaceutica Nv | Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central. |
| AU2006259020C1 (en) | 2005-06-17 | 2012-01-19 | Janssen Pharmaceutica N.V. | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
| US8765223B2 (en) * | 2008-05-08 | 2014-07-01 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8507040B2 (en) | 2008-05-08 | 2013-08-13 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644462A1 (de) * | 1986-12-24 | 1988-07-07 | Basf Ag | Verfahren zur herstellung von 5h-dibenzo(a,d)cyclohepten-5-onen |
| JP2656720B2 (ja) * | 1992-12-09 | 1997-09-24 | 武田薬品工業株式会社 | 光学活性アミノクマラン誘導体 |
| ATE201680T1 (de) * | 1994-03-16 | 2001-06-15 | Cenes Ltd | 2,3,4,5-tetrahydro-1h-3-benzazepin säure- additions-salze |
| DE69720709T2 (de) * | 1996-04-12 | 2004-03-11 | Janssen Pharmaceutica N.V. | Substituierte tetracyclische tetrahydrofuranderivate |
| KR19990044257A (ko) | 1996-05-20 | 1999-06-25 | 디르크 반테 | 생체이용율이 개선된 항진균성 조성물 |
| UA52778C2 (uk) * | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
| US6281247B1 (en) * | 1998-03-03 | 2001-08-28 | Novo Nordisk A/S | Salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)amide |
| HUP9904624A2 (hu) * | 1999-12-17 | 2002-01-28 | Sanofi-Synthelabo | Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| EP1186303A3 (en) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist |
-
2002
- 2002-08-11 UA UA20040604168A patent/UA79248C2/uk unknown
- 2002-11-07 MY MYPI20024166A patent/MY128237A/en unknown
- 2002-11-08 BR BR0212770-9A patent/BR0212770A/pt not_active IP Right Cessation
- 2002-11-08 IL IL16186602A patent/IL161866A0/xx unknown
- 2002-11-08 NZ NZ531739A patent/NZ531739A/en not_active IP Right Cessation
- 2002-11-08 ES ES02781214T patent/ES2244818T3/es not_active Expired - Lifetime
- 2002-11-08 EA EA200400656A patent/EA006980B1/ru not_active IP Right Cessation
- 2002-11-08 HU HU0402224A patent/HUP0402224A3/hu unknown
- 2002-11-08 US US10/491,799 patent/US7317115B2/en not_active Expired - Fee Related
- 2002-11-08 DE DE60204982T patent/DE60204982T2/de not_active Expired - Lifetime
- 2002-11-08 TW TW091132840A patent/TW200407117A/zh unknown
- 2002-11-08 JP JP2003542168A patent/JP2005508988A/ja active Pending
- 2002-11-08 CN CN02821918XA patent/CN1582282B/zh not_active Expired - Fee Related
- 2002-11-08 EP EP02781214A patent/EP1446397B1/en not_active Expired - Lifetime
- 2002-11-08 PL PL02368456A patent/PL368456A1/xx unknown
- 2002-11-08 KR KR1020047002379A patent/KR100962325B1/ko not_active IP Right Cessation
- 2002-11-08 CA CA2465043A patent/CA2465043C/en not_active Expired - Fee Related
- 2002-11-08 AU AU2002349327A patent/AU2002349327B2/en not_active Ceased
- 2002-11-08 AT AT02781214T patent/ATE299138T1/de not_active IP Right Cessation
- 2002-11-08 AR ARP020104298A patent/AR037285A1/es unknown
- 2002-11-08 WO PCT/EP2002/011136 patent/WO2003040122A1/en active IP Right Grant
- 2002-11-08 MX MXPA04004365A patent/MXPA04004365A/es active IP Right Grant
-
2004
- 2004-05-05 NO NO20041848A patent/NO328548B1/no not_active IP Right Cessation
- 2004-05-05 HR HR20040395A patent/HRP20040395A2/hr not_active Application Discontinuation
- 2004-05-06 ZA ZA200403454A patent/ZA200403454B/en unknown
- 2004-05-06 IL IL161866A patent/IL161866A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200403454B (en) | 2005-08-31 |
| CN1582282A (zh) | 2005-02-16 |
| NO20041848L (no) | 2004-05-05 |
| DE60204982D1 (de) | 2005-08-11 |
| EP1446397A1 (en) | 2004-08-18 |
| ATE299138T1 (de) | 2005-07-15 |
| ES2244818T3 (es) | 2005-12-16 |
| NO328548B1 (no) | 2010-03-15 |
| HRP20040395A2 (en) | 2005-04-30 |
| UA79248C2 (en) | 2007-06-11 |
| IL161866A0 (en) | 2005-11-20 |
| AR037285A1 (es) | 2004-11-03 |
| EA006980B1 (ru) | 2006-06-30 |
| EP1446397B1 (en) | 2005-07-06 |
| IL161866A (en) | 2010-04-29 |
| US7317115B2 (en) | 2008-01-08 |
| MY128237A (en) | 2007-01-31 |
| PL368456A1 (en) | 2005-03-21 |
| AU2002349327B2 (en) | 2008-10-23 |
| KR100962325B1 (ko) | 2010-06-11 |
| HUP0402224A2 (hu) | 2005-02-28 |
| HUP0402224A3 (en) | 2007-05-29 |
| TW200407117A (en) | 2004-05-16 |
| US20050085533A1 (en) | 2005-04-21 |
| KR20050044310A (ko) | 2005-05-12 |
| CA2465043C (en) | 2011-02-15 |
| JP2005508988A (ja) | 2005-04-07 |
| WO2003040122A1 (en) | 2003-05-15 |
| CA2465043A1 (en) | 2003-05-15 |
| EA200400656A1 (ru) | 2004-10-28 |
| CN1582282B (zh) | 2012-06-06 |
| NZ531739A (en) | 2005-02-25 |
| DE60204982T2 (de) | 2006-04-27 |
| BR0212770A (pt) | 2004-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY128659A (en) | Novel aminodicarboxylic acid derivatives having pharmaceutical properties | |
| JO2372B1 (en) | Source drugs of 4-phenylpyridine derivatives | |
| RS28004A (en) | Azabicycle-substituted fused- heteroaryl compounds for the treatment of disease | |
| MXPA03006248A (es) | Derivados de acido fumarico como inhibidores de nf-kappab. | |
| HUT62893A (en) | Process for producing substituted pyrimidine derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
| MXPA04000814A (es) | Derivados de 2h-piridazina-3-ona novedosos, composiciones farmaceuticas que contienen a los mismos y un procedimiento para la preparacion del ingrediente activo. | |
| EP1348706A4 (en) | SUBSTITUTED THIAZOLE DERIVATIVES CARRYING 3-PYRIDYL GROUPS, PROCESS FOR THEIR PRODUCTION AND USE THEREOF | |
| ATE457981T1 (de) | 3-amido-1,2-benzisoxazolderivate, herstellungsverfahren und deren verwendung | |
| MY135218A (en) | 2,6-quinolinyl and 2,6-naphthyl derivatives and their use in the treatment of vla-4 dependent diseases | |
| MXPA04004365A (es) | Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido. | |
| GEP20074256B (en) | Novel benzothiadiazine, process for their preparation and pharmaceutical compositions containing | |
| MX2023010937A (es) | Derivados de morfolinas sustituidas y usos de estos. | |
| MX9803730A (es) | Nuevo proceso de preparacion de derivados de fenilimidazolidina. | |
| MXPA05004273A (es) | Derivados de fenilalquil y piridilalquil piperazina. | |
| AU3608195A (en) | N-substituted piperidinyl bicyclic benzoate derivatives | |
| TW360650B (en) | Pyridin-2-ylmethyloxy-pyridin-5-ylcarbamoyl-indoline derivatives, a process for the preparation thereof, and a pharmaceutical composition comprising them | |
| YU76500A (sh) | Hemijska sinzeza morfolinskih derivata | |
| SG146627A1 (en) | Imidazole derivatives | |
| AP1396A (en) | 1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives. | |
| HUP9601331A2 (hu) | Piperazin- illetve homopiperazinszármazékok, eljárás előállításukra, és ilyen hatóanyagot tartalmazó gyógyászati készítmények | |
| DE602005012826D1 (de) | Neue mao-b-hemmer | |
| MXPA04002784A (es) | Sales farmaceuticamente aceptables de 20(s)-camptotecinas. | |
| MY104630A (en) | 4(1h) ouinoline derivatives | |
| YU79401A (sh) | Derivati 1-trifluorometil-4-hidroksi-7-piperidinil- aminometilhromana | |
| TH60797A (th) | เกลือแมนเดเลตชนิดใหม่ของอนุพันธ์เททราไซคลิคเททราไฮโดรฟิวแรนที่มีหมู่แทนที่ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights |