AR037285A1 - Sales de mandelato de derivados de tetrahidrofurano tetraciclico sustituido - Google Patents
Sales de mandelato de derivados de tetrahidrofurano tetraciclico sustituidoInfo
- Publication number
- AR037285A1 AR037285A1 ARP020104298A ARP020104298A AR037285A1 AR 037285 A1 AR037285 A1 AR 037285A1 AR P020104298 A ARP020104298 A AR P020104298A AR P020104298 A ARP020104298 A AR P020104298A AR 037285 A1 AR037285 A1 AR 037285A1
- Authority
- AR
- Argentina
- Prior art keywords
- mandelate
- present
- salts according
- mandelate salts
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
El objetivo de la presente es presentar una sal de mandelato de un derivado de tetrahidrofurano tetracíclico sustituido de acuerdo con la fórmula (1), las formas de N-óxido y las formas estereoquímicamente isoméricas de los mismos, en los cuales cada uno de R1 y R2 es independientemente hidrógeno o alquilo C1-6 y cada uno de R3 y R4 es independientemente hidrógeno o halógeno. En las definiciones que anteceden, alquilo C1-6 define radicales hidrocarburo rectos o ramificados con 1 a 6 átomos de carbono tales como, por ejemplo, metilo, etilo, propilo, butilo, 1-metilpropilo, 1,1-dimetiletilo, pentilo y hexilo. La sal de mandelato no es fotosensible y es mucho más estable que las sales de la técnica anterior a temperatura ambiente, a temperatura incrementada y a humedades relativas elevadas, así como en medios acuosos. También se describen composiciones farmacéuticas que comprenden las sales de mandelato de acuerdo con la presente presente, las sales de mandelato de acuerdo con la presente para usar como medicamento, un proceso para la preparación de las sales de mandelato de acuerdo con la presente y uso de las sales de mandelato y composiciones farmacéuticas que comprenden las sales de mandelato de acuerdo con la presente para el tratamiento o la prevención de trastornos del SNC, trastornos cardiovasculares y trastornos gastrointestinales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204465 | 2001-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037285A1 true AR037285A1 (es) | 2004-11-03 |
Family
ID=8181272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104298A AR037285A1 (es) | 2001-11-09 | 2002-11-08 | Sales de mandelato de derivados de tetrahidrofurano tetraciclico sustituido |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7317115B2 (es) |
| EP (1) | EP1446397B1 (es) |
| JP (1) | JP2005508988A (es) |
| KR (1) | KR100962325B1 (es) |
| CN (1) | CN1582282B (es) |
| AR (1) | AR037285A1 (es) |
| AT (1) | ATE299138T1 (es) |
| AU (1) | AU2002349327B2 (es) |
| BR (1) | BR0212770A (es) |
| CA (1) | CA2465043C (es) |
| DE (1) | DE60204982T2 (es) |
| EA (1) | EA006980B1 (es) |
| ES (1) | ES2244818T3 (es) |
| HR (1) | HRP20040395A2 (es) |
| HU (1) | HUP0402224A3 (es) |
| IL (2) | IL161866A0 (es) |
| MX (1) | MXPA04004365A (es) |
| MY (1) | MY128237A (es) |
| NO (1) | NO328548B1 (es) |
| NZ (1) | NZ531739A (es) |
| PL (1) | PL368456A1 (es) |
| TW (1) | TW200407117A (es) |
| UA (1) | UA79248C2 (es) |
| WO (1) | WO2003040122A1 (es) |
| ZA (1) | ZA200403454B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ532806A (en) * | 2001-12-07 | 2006-01-27 | Janssen Pharmaceutica Nv | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
| WO2005013969A1 (en) * | 2003-07-15 | 2005-02-17 | Janssen Pharmaceutica N.V. | Antipsychotic agent with socializing properties |
| WO2006061392A2 (en) | 2004-12-07 | 2006-06-15 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| CN101107254B (zh) | 2005-01-27 | 2010-12-08 | 詹森药业有限公司 | 在中枢神经系统病症的治疗中作为5ht2抑制剂的杂环四环四氢呋喃衍生物 |
| NZ564181A (en) | 2005-06-17 | 2010-02-26 | Janssen Pharmaceutica Nv | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
| US8765223B2 (en) * | 2008-05-08 | 2014-07-01 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8507040B2 (en) | 2008-05-08 | 2013-08-13 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644462A1 (de) * | 1986-12-24 | 1988-07-07 | Basf Ag | Verfahren zur herstellung von 5h-dibenzo(a,d)cyclohepten-5-onen |
| JP2656720B2 (ja) * | 1992-12-09 | 1997-09-24 | 武田薬品工業株式会社 | 光学活性アミノクマラン誘導体 |
| JPH09510222A (ja) * | 1994-03-16 | 1997-10-14 | ノボ ノルディスク アクティーゼルスカブ | ２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピン化合物の酸付加塩 |
| TR199801164T2 (xx) * | 1996-04-12 | 1998-10-21 | Janssen Pharmaceutica N.V. | S�bstit�e edilmi� tetrasiklik tetrahidrofuran t�revleri. |
| CA2240161C (en) | 1996-05-20 | 2005-05-24 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
| UA52778C2 (uk) * | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
| US6281247B1 (en) * | 1998-03-03 | 2001-08-28 | Novo Nordisk A/S | Salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)amide |
| HUP9904624A2 (hu) * | 1999-12-17 | 2002-01-28 | Sanofi-Synthelabo | Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| EP1186303A3 (en) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist |
-
2002
- 2002-08-11 UA UA20040604168A patent/UA79248C2/uk unknown
- 2002-11-07 MY MYPI20024166A patent/MY128237A/en unknown
- 2002-11-08 US US10/491,799 patent/US7317115B2/en not_active Expired - Fee Related
- 2002-11-08 PL PL02368456A patent/PL368456A1/xx unknown
- 2002-11-08 TW TW091132840A patent/TW200407117A/zh unknown
- 2002-11-08 DE DE60204982T patent/DE60204982T2/de not_active Expired - Lifetime
- 2002-11-08 ES ES02781214T patent/ES2244818T3/es not_active Expired - Lifetime
- 2002-11-08 AR ARP020104298A patent/AR037285A1/es unknown
- 2002-11-08 NZ NZ531739A patent/NZ531739A/en not_active IP Right Cessation
- 2002-11-08 KR KR1020047002379A patent/KR100962325B1/ko not_active IP Right Cessation
- 2002-11-08 HU HU0402224A patent/HUP0402224A3/hu unknown
- 2002-11-08 BR BR0212770-9A patent/BR0212770A/pt not_active IP Right Cessation
- 2002-11-08 IL IL16186602A patent/IL161866A0/xx unknown
- 2002-11-08 CA CA2465043A patent/CA2465043C/en not_active Expired - Fee Related
- 2002-11-08 JP JP2003542168A patent/JP2005508988A/ja active Pending
- 2002-11-08 AU AU2002349327A patent/AU2002349327B2/en not_active Ceased
- 2002-11-08 AT AT02781214T patent/ATE299138T1/de not_active IP Right Cessation
- 2002-11-08 WO PCT/EP2002/011136 patent/WO2003040122A1/en active IP Right Grant
- 2002-11-08 EA EA200400656A patent/EA006980B1/ru not_active IP Right Cessation
- 2002-11-08 CN CN02821918XA patent/CN1582282B/zh not_active Expired - Fee Related
- 2002-11-08 MX MXPA04004365A patent/MXPA04004365A/es active IP Right Grant
- 2002-11-08 EP EP02781214A patent/EP1446397B1/en not_active Expired - Lifetime
-
2004
- 2004-05-05 HR HR20040395A patent/HRP20040395A2/hr not_active Application Discontinuation
- 2004-05-05 NO NO20041848A patent/NO328548B1/no not_active IP Right Cessation
- 2004-05-06 IL IL161866A patent/IL161866A/en not_active IP Right Cessation
- 2004-05-06 ZA ZA200403454A patent/ZA200403454B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR041566A1 (es) | Derivados de indol utiles para el tratamiento de enfermedades | |
| CO5700824A2 (es) | Nuevos compuestos heterociclicos utiles para el tratamiento de desordenes inflamatorios y alergicos: proceso para su preparacion y composiciones farmaceuticas que los contienen | |
| AR039219A1 (es) | Compuestos imidazo-sustituidos | |
| HRP20050708A2 (en) | Piperidine-benzenesulfonamide derivatives | |
| MX2012007273A (es) | Pteridinonas como inhibidores de la quinasa tipo polo. | |
| SE0303180D0 (sv) | Novel compounds | |
| HUP0401538A2 (hu) | Új, helyettesített aminometilcsoportot tartalmazó N-(arilszulfonil)-béta-aminosav-származékok, előállításukra alkalmas eljárás és a vegyületeket tartalmazó gyógyászati készítmények | |
| MXPA05009359A (es) | Tetrahidroisoquinolinas 2,5- y 2,6 substituidas para uso como moduladores 5-ht6. | |
| SE0302232D0 (sv) | Novel Compounds | |
| GEP20094736B (en) | Prodrugs of piperazine and substituted piperidine antiviral agents | |
| AR056320A1 (es) | Derivados de cromano y cromeno, procesos de obtencion, composiciones farmaceuticas y usos de los mismos | |
| NO20080765L (no) | Prodrug av eksitasjonsaminosyrer | |
| AR034268A1 (es) | Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion | |
| MXPA05006420A (es) | Derivados de pirimidina para el tratamiento de crecimiento celular anormal. | |
| EA200870282A1 (ru) | Производные амина | |
| AR036659A1 (es) | Compuestos derivados de fenil-piperazina, fenil-piperidina y fenil-tetrahidropiridina como inhibidores de la reabsorcion de la serotonina, una composicion farmaceutica y utilizacion de los mismos para la preparacion de medicamentos | |
| MX2007012883A (es) | Derivados de dihidrobenzofurano y usos de los mismos. | |
| AR041297A1 (es) | Derivados de 4-pirrolidino- fenil- bencil eter | |
| BRPI0411294A (pt) | derivados de amino-propanol | |
| NO20084516L (no) | Terfenylderivater for behandling av alzheimers sykdom | |
| AR040489A1 (es) | Compuestos derivados de 3-fenil-propionamido, 3-fenil-acrilamido y 3-fenil-propinamido, su uso para la elaboracion de medicamentos, un proceso para elaborar los compuestos y medicamentos que los contienen | |
| HUP0300052A2 (en) | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists, process for their preparation and pharmaceutical compositions containing them | |
| UY24881A1 (es) | 2-amino-6-(4-fenoxi-2-sustituido)-piridinas sustituidas | |
| AR037285A1 (es) | Sales de mandelato de derivados de tetrahidrofurano tetraciclico sustituido | |
| CL2003002565A1 (es) | Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |