BR0212770A - Sais mandelato de derivados de tetrahidrofurano tetracìclico substituìdo - Google Patents
Sais mandelato de derivados de tetrahidrofurano tetracìclico substituìdoInfo
- Publication number
- BR0212770A BR0212770A BR0212770-9A BR0212770A BR0212770A BR 0212770 A BR0212770 A BR 0212770A BR 0212770 A BR0212770 A BR 0212770A BR 0212770 A BR0212770 A BR 0212770A
- Authority
- BR
- Brazil
- Prior art keywords
- mandelate
- salts
- mandelate salts
- salts according
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
"SAIS MANDELATO DE DERIVADOS DE TETRAHIDROFURANO TETRACìCLICO SUBSTITUìDO". O objetivo da presente invenção é um novo sal mandelato de um derivado de tetrahidrofurano tetracíclico substituído de acordo com a Fórmula (I), as formas de N-óxido e as formas estereoquimicamente isoméricas do mesmo, em que R^ 1^ e R^ 2^ cada um independentemente é hidrogênio ou C~ 1~-C~ 6~-alquila e em que R^ 3^ e R^ 4^ cada um independentemente é hidrogênio ou halogênio. Nas definições anteriores, C~ 1~-C~ 6~-alquila define radicais hidrocarbonetos de cadeia reta e ramificada que têm desde 1 até 6 átomos de carbono tais como, por exemplo, metila, etila, propila, butila, 1-metil-propila, 1,1 dimetiletila, pentila ou hexila. O novo sal mandelato não é sensível à luz e é muito mais estável do que os sais da técnica anterior à temperatura ambiente, temperatura melhorada e a umidades relativamente altas e em meios aquosos. Também são divulgadas composições farmacêuticas que compreendem sais mandelato de acordo com a invenção, sais mandelato de acordo com a invenção para uso como um medicamento, um processo para a preparação dos sais mandelato de acordo com a invenção e o uso dos sais mandelato e de composições farmacêuticas que compreendem sais mandelato de acordo com a invenção para o tratamento ou para a prevenção de distúrbios do SNC, distúrbios cardiovasculares e distúrbios gastrointestinais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204465 | 2001-11-09 | ||
| PCT/EP2002/011136 WO2003040122A1 (en) | 2001-11-09 | 2002-11-08 | Novel mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0212770A true BR0212770A (pt) | 2004-10-13 |
Family
ID=8181272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0212770-9A BR0212770A (pt) | 2001-11-09 | 2002-11-08 | Sais mandelato de derivados de tetrahidrofurano tetracìclico substituìdo |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7317115B2 (pt) |
| EP (1) | EP1446397B1 (pt) |
| JP (1) | JP2005508988A (pt) |
| KR (1) | KR100962325B1 (pt) |
| CN (1) | CN1582282B (pt) |
| AR (1) | AR037285A1 (pt) |
| AT (1) | ATE299138T1 (pt) |
| AU (1) | AU2002349327B2 (pt) |
| BR (1) | BR0212770A (pt) |
| CA (1) | CA2465043C (pt) |
| DE (1) | DE60204982T2 (pt) |
| EA (1) | EA006980B1 (pt) |
| ES (1) | ES2244818T3 (pt) |
| HR (1) | HRP20040395A2 (pt) |
| HU (1) | HUP0402224A3 (pt) |
| IL (2) | IL161866A0 (pt) |
| MX (1) | MXPA04004365A (pt) |
| MY (1) | MY128237A (pt) |
| NO (1) | NO328548B1 (pt) |
| NZ (1) | NZ531739A (pt) |
| PL (1) | PL368456A1 (pt) |
| TW (1) | TW200407117A (pt) |
| UA (1) | UA79248C2 (pt) |
| WO (1) | WO2003040122A1 (pt) |
| ZA (1) | ZA200403454B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60203937T2 (de) * | 2001-12-07 | 2006-05-11 | Janssen Pharmaceutica N.V. | Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten |
| WO2005013969A1 (en) * | 2003-07-15 | 2005-02-17 | Janssen Pharmaceutica N.V. | Antipsychotic agent with socializing properties |
| RU2401257C2 (ru) | 2004-12-07 | 2010-10-10 | Янссен Фармацевтика Н.В. | Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена |
| MX2007009092A (es) | 2005-01-27 | 2007-09-12 | Janssen Pharmaceutica Nv | Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central. |
| AU2006259020C1 (en) | 2005-06-17 | 2012-01-19 | Janssen Pharmaceutica N.V. | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
| US8765223B2 (en) * | 2008-05-08 | 2014-07-01 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8507040B2 (en) | 2008-05-08 | 2013-08-13 | Air Products And Chemicals, Inc. | Binary and ternary metal chalcogenide materials and method of making and using same |
| US8962675B1 (en) * | 2013-09-12 | 2015-02-24 | Abbvie Inc. | Atrasentan mandelate salts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644462A1 (de) * | 1986-12-24 | 1988-07-07 | Basf Ag | Verfahren zur herstellung von 5h-dibenzo(a,d)cyclohepten-5-onen |
| JP2656720B2 (ja) * | 1992-12-09 | 1997-09-24 | 武田薬品工業株式会社 | 光学活性アミノクマラン誘導体 |
| ATE201680T1 (de) * | 1994-03-16 | 2001-06-15 | Cenes Ltd | 2,3,4,5-tetrahydro-1h-3-benzazepin säure- additions-salze |
| DE69720709T2 (de) * | 1996-04-12 | 2004-03-11 | Janssen Pharmaceutica N.V. | Substituierte tetracyclische tetrahydrofuranderivate |
| KR19990044257A (ko) | 1996-05-20 | 1999-06-25 | 디르크 반테 | 생체이용율이 개선된 항진균성 조성물 |
| UA52778C2 (uk) * | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
| US6281247B1 (en) * | 1998-03-03 | 2001-08-28 | Novo Nordisk A/S | Salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)amide |
| HUP9904624A2 (hu) * | 1999-12-17 | 2002-01-28 | Sanofi-Synthelabo | Szacharinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és intermedierjeik |
| EP1186303A3 (en) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist |
-
2002
- 2002-08-11 UA UA20040604168A patent/UA79248C2/uk unknown
- 2002-11-07 MY MYPI20024166A patent/MY128237A/en unknown
- 2002-11-08 BR BR0212770-9A patent/BR0212770A/pt not_active IP Right Cessation
- 2002-11-08 IL IL16186602A patent/IL161866A0/xx unknown
- 2002-11-08 NZ NZ531739A patent/NZ531739A/en not_active IP Right Cessation
- 2002-11-08 ES ES02781214T patent/ES2244818T3/es not_active Expired - Lifetime
- 2002-11-08 EA EA200400656A patent/EA006980B1/ru not_active IP Right Cessation
- 2002-11-08 HU HU0402224A patent/HUP0402224A3/hu unknown
- 2002-11-08 US US10/491,799 patent/US7317115B2/en not_active Expired - Fee Related
- 2002-11-08 DE DE60204982T patent/DE60204982T2/de not_active Expired - Lifetime
- 2002-11-08 TW TW091132840A patent/TW200407117A/zh unknown
- 2002-11-08 JP JP2003542168A patent/JP2005508988A/ja active Pending
- 2002-11-08 CN CN02821918XA patent/CN1582282B/zh not_active Expired - Fee Related
- 2002-11-08 EP EP02781214A patent/EP1446397B1/en not_active Expired - Lifetime
- 2002-11-08 PL PL02368456A patent/PL368456A1/xx unknown
- 2002-11-08 KR KR1020047002379A patent/KR100962325B1/ko not_active IP Right Cessation
- 2002-11-08 CA CA2465043A patent/CA2465043C/en not_active Expired - Fee Related
- 2002-11-08 AU AU2002349327A patent/AU2002349327B2/en not_active Ceased
- 2002-11-08 AT AT02781214T patent/ATE299138T1/de not_active IP Right Cessation
- 2002-11-08 AR ARP020104298A patent/AR037285A1/es unknown
- 2002-11-08 WO PCT/EP2002/011136 patent/WO2003040122A1/en active IP Right Grant
- 2002-11-08 MX MXPA04004365A patent/MXPA04004365A/es active IP Right Grant
-
2004
- 2004-05-05 NO NO20041848A patent/NO328548B1/no not_active IP Right Cessation
- 2004-05-05 HR HR20040395A patent/HRP20040395A2/hr not_active Application Discontinuation
- 2004-05-06 ZA ZA200403454A patent/ZA200403454B/en unknown
- 2004-05-06 IL IL161866A patent/IL161866A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 307/93, A61K 31/343, A61P 25/18 Ipc: C07D 307/93 (2011.01), A61K 31/343 (2011.01), A61P |
|
| B25C | Requirement related to requested transfer of rights |
Owner name: JANSEN PHARMACEUTICA N.V. (BE) Free format text: A FIM DE ATENDER A TRANSFERENCIA REQUERIDA ATRAVES DA PETICAO NO 020120000065/RJ DE 02/01/2012, E NECESSARIO COMPLEMENTAR A GUIA RELATIVA A CESSAO, BEM COMO RECOLHER A GUIA REFERENTE A ESTA EXIGENCIA. |
|
| B25A | Requested transfer of rights approved |
Owner name: ELANCO ANIMAL HEALTH IRELAND LIMITED (IE) Free format text: TRANSFERIDO DE: JANSEN PHARMACEUTICA N.V. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |