ATE342261T1 - Pyranderivate als inhibitoren von ace und nep - Google Patents

Pyranderivate als inhibitoren von ace und nep

Info

Publication number
ATE342261T1
ATE342261T1 AT02779395T AT02779395T ATE342261T1 AT E342261 T1 ATE342261 T1 AT E342261T1 AT 02779395 T AT02779395 T AT 02779395T AT 02779395 T AT02779395 T AT 02779395T AT E342261 T1 ATE342261 T1 AT E342261T1
Authority
AT
Austria
Prior art keywords
ace
nep
pyrand
inhibitors
derivatives
Prior art date
Application number
AT02779395T
Other languages
English (en)
Inventor
Cynthia Anne Fink
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE342261T1 publication Critical patent/ATE342261T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT02779395T 2001-09-21 2002-09-20 Pyranderivate als inhibitoren von ace und nep ATE342261T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32382501P 2001-09-21 2001-09-21

Publications (1)

Publication Number Publication Date
ATE342261T1 true ATE342261T1 (de) 2006-11-15

Family

ID=23260883

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02779395T ATE342261T1 (de) 2001-09-21 2002-09-20 Pyranderivate als inhibitoren von ace und nep

Country Status (12)

Country Link
US (2) US7071169B2 (de)
EP (1) EP1430045B1 (de)
JP (1) JP4263095B2 (de)
CN (1) CN1304415C (de)
AT (1) ATE342261T1 (de)
BR (1) BR0212899A (de)
CA (1) CA2456281A1 (de)
DE (1) DE60215368T2 (de)
ES (1) ES2274106T3 (de)
HK (1) HK1068332A1 (de)
PT (1) PT1430045E (de)
WO (1) WO2003027091A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1430045E (pt) 2001-09-21 2007-01-31 Novartis Ag Derivados de pirano como inibidores de ace e nep
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
FI20040674A0 (fi) * 2004-05-12 2004-05-12 Orion Corp Menetelmä tromboembolisten sairauksien estoon
JP2008524159A (ja) * 2004-12-15 2008-07-10 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング ＮＥＰ阻害剤、内因性エンドセリン産生系の阻害剤およびＨＭＧＣｏＡレダクターゼ阻害剤を含有する医薬組成物
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
ATE464904T1 (de) * 2005-02-18 2010-05-15 Solvay Pharm Gmbh Pharmazeutische zusammensetzungen mit nep- inhibitoren, inhibitoren des endogenes endothelin produzierenden systems und diuretika
EP1897879A3 (de) 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-Substituierte Piperidine als Renin-Inhibitoren
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
US8829209B2 (en) 2006-01-11 2014-09-09 Seikagaku Corporation Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
JP2010536880A (ja) * 2007-08-22 2010-12-02 ギリード・コロラド・インコーポレーテッド 糖尿病の合併症のための療法
WO2009127251A1 (en) * 2008-04-16 2009-10-22 Novartis Ag Combinations comprising a renin inhibitor
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211648A (ja) * 1990-07-27 1992-08-03 Nippon Kayaku Co Ltd ケト酸アミド誘導体
ES2148305T3 (es) 1993-11-16 2000-10-16 Novartis Ag Derivados de aminoacidos ciclicos que tienen actividad inhibidora de ace y nep.
US5432186A (en) 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
IL138246A0 (en) * 1998-04-23 2001-10-31 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
WO1999055723A1 (en) 1998-04-23 1999-11-04 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
WO2001077095A2 (en) 2000-04-06 2001-10-18 Novartis Ag Derivatives of alpha-mercaptoacetamide
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
PT1430045E (pt) 2001-09-21 2007-01-31 Novartis Ag Derivados de pirano como inibidores de ace e nep

Also Published As

Publication number Publication date
HK1068332A1 (en) 2005-04-29
BR0212899A (pt) 2004-11-03
DE60215368D1 (de) 2006-11-23
ES2274106T3 (es) 2007-05-16
DE60215368T2 (de) 2007-08-16
CN1555372A (zh) 2004-12-15
JP4263095B2 (ja) 2009-05-13
JP2005504099A (ja) 2005-02-10
US20060194742A1 (en) 2006-08-31
PT1430045E (pt) 2007-01-31
US20040266698A1 (en) 2004-12-30
CN1304415C (zh) 2007-03-14
CA2456281A1 (en) 2003-04-03
EP1430045B1 (de) 2006-10-11
EP1430045A1 (de) 2004-06-23
WO2003027091A1 (en) 2003-04-03
US7071169B2 (en) 2006-07-04

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