DE60215368D1 - Pyranderivate als inhibitoren von ace und nep - Google Patents
Pyranderivate als inhibitoren von ace und nepInfo
- Publication number
- DE60215368D1 DE60215368D1 DE60215368T DE60215368T DE60215368D1 DE 60215368 D1 DE60215368 D1 DE 60215368D1 DE 60215368 T DE60215368 T DE 60215368T DE 60215368 T DE60215368 T DE 60215368T DE 60215368 D1 DE60215368 D1 DE 60215368D1
- Authority
- DE
- Germany
- Prior art keywords
- ace
- nep
- sub
- pyranderivates
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32382501P | 2001-09-21 | 2001-09-21 | |
US323825P | 2001-09-21 | ||
PCT/EP2002/010608 WO2003027091A1 (en) | 2001-09-21 | 2002-09-20 | Pyrane derivatives as both ace- and nep- inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60215368D1 true DE60215368D1 (de) | 2006-11-23 |
DE60215368T2 DE60215368T2 (de) | 2007-08-16 |
Family
ID=23260883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60215368T Expired - Lifetime DE60215368T2 (de) | 2001-09-21 | 2002-09-20 | Pyranderivate als inhibitoren von ace und nep |
Country Status (12)
Country | Link |
---|---|
US (2) | US7071169B2 (de) |
EP (1) | EP1430045B1 (de) |
JP (1) | JP4263095B2 (de) |
CN (1) | CN1304415C (de) |
AT (1) | ATE342261T1 (de) |
BR (1) | BR0212899A (de) |
CA (1) | CA2456281A1 (de) |
DE (1) | DE60215368T2 (de) |
ES (1) | ES2274106T3 (de) |
HK (1) | HK1068332A1 (de) |
PT (1) | PT1430045E (de) |
WO (1) | WO2003027091A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2274106T3 (es) | 2001-09-21 | 2007-05-16 | Novartis Ag | Derivados de pirano como inhibidores tanto de ace como de nep. |
TW200900399A (en) | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
FI20040674A0 (fi) * | 2004-05-12 | 2004-05-12 | Orion Corp | Menetelmä tromboembolisten sairauksien estoon |
CA2590278A1 (en) | 2004-12-15 | 2006-06-22 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and hmg coa reductase inhibitors |
WO2006087371A1 (en) * | 2005-02-18 | 2006-08-24 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics |
US20060205625A1 (en) * | 2005-02-18 | 2006-09-14 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics |
TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
EP1897879A3 (de) | 2005-03-31 | 2008-06-11 | Speedel Experimenta AG | 2,4,5-Substituierte Piperidine als Renin-Inhibitoren |
JP3975226B2 (ja) | 2006-01-11 | 2007-09-12 | 生化学工業株式会社 | シクロアルキルカルボニルアミノ酸誘導体及びその製造方法 |
JP4047365B2 (ja) | 2006-01-11 | 2008-02-13 | 生化学工業株式会社 | シクロアルカンカルボキサミド誘導体及びその製造方法 |
US8829209B2 (en) | 2006-01-11 | 2014-09-09 | Seikagaku Corporation | Cycloalkylcarbonylamino acid ester derivative and process for producing the same |
EP2190433A2 (de) * | 2007-08-22 | 2010-06-02 | Gilead Colorado, Inc. | Therapie für diabeteskomplikationen |
WO2009127251A1 (en) * | 2008-04-16 | 2009-10-22 | Novartis Ag | Combinations comprising a renin inhibitor |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04211648A (ja) * | 1990-07-27 | 1992-08-03 | Nippon Kayaku Co Ltd | ケト酸アミド誘導体 |
ATE193706T1 (de) | 1993-11-16 | 2000-06-15 | Novartis Ag | Zyklische aminosäure-derivate mit ace und nep inhibierender aktivität |
US5432186A (en) * | 1993-11-16 | 1995-07-11 | Ciba-Geigy Corporation | Cyclic amino acid derivatives |
DE69923676T2 (de) | 1998-04-23 | 2006-01-12 | Novartis Ag | Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen |
HUP0101640A3 (en) * | 1998-04-23 | 2002-10-28 | Novartis Ag | Certain thoil inhibitors of endothelin-converting enzyme |
AU2001254776A1 (en) | 2000-04-06 | 2001-10-23 | Novartis Ag | Organic compounds |
US6777443B2 (en) * | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
ES2274106T3 (es) | 2001-09-21 | 2007-05-16 | Novartis Ag | Derivados de pirano como inhibidores tanto de ace como de nep. |
-
2002
- 2002-09-20 ES ES02779395T patent/ES2274106T3/es not_active Expired - Lifetime
- 2002-09-20 AT AT02779395T patent/ATE342261T1/de not_active IP Right Cessation
- 2002-09-20 BR BR0212899-3A patent/BR0212899A/pt not_active IP Right Cessation
- 2002-09-20 JP JP2003530679A patent/JP4263095B2/ja not_active Expired - Fee Related
- 2002-09-20 DE DE60215368T patent/DE60215368T2/de not_active Expired - Lifetime
- 2002-09-20 US US10/487,742 patent/US7071169B2/en not_active Expired - Fee Related
- 2002-09-20 CA CA002456281A patent/CA2456281A1/en not_active Abandoned
- 2002-09-20 CN CNB028183010A patent/CN1304415C/zh not_active Expired - Fee Related
- 2002-09-20 WO PCT/EP2002/010608 patent/WO2003027091A1/en active IP Right Grant
- 2002-09-20 EP EP02779395A patent/EP1430045B1/de not_active Expired - Lifetime
- 2002-09-20 PT PT02779395T patent/PT1430045E/pt unknown
-
2004
- 2004-12-15 HK HK04109973A patent/HK1068332A1/xx not_active IP Right Cessation
-
2006
- 2006-05-01 US US11/414,906 patent/US20060194742A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040266698A1 (en) | 2004-12-30 |
HK1068332A1 (en) | 2005-04-29 |
JP4263095B2 (ja) | 2009-05-13 |
JP2005504099A (ja) | 2005-02-10 |
CN1555372A (zh) | 2004-12-15 |
US7071169B2 (en) | 2006-07-04 |
ATE342261T1 (de) | 2006-11-15 |
PT1430045E (pt) | 2007-01-31 |
EP1430045B1 (de) | 2006-10-11 |
CN1304415C (zh) | 2007-03-14 |
DE60215368T2 (de) | 2007-08-16 |
BR0212899A (pt) | 2004-11-03 |
CA2456281A1 (en) | 2003-04-03 |
EP1430045A1 (de) | 2004-06-23 |
ES2274106T3 (es) | 2007-05-16 |
WO2003027091A1 (en) | 2003-04-03 |
US20060194742A1 (en) | 2006-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
R082 | Change of representative |
Ref document number: 1430045 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |