HK1068332A1 - Pyrane derivatives as both ace-and nep-inhibitors - Google Patents

Pyrane derivatives as both ace-and nep-inhibitors

Info

Publication number
HK1068332A1
HK1068332A1 HK04109973A HK04109973A HK1068332A1 HK 1068332 A1 HK1068332 A1 HK 1068332A1 HK 04109973 A HK04109973 A HK 04109973A HK 04109973 A HK04109973 A HK 04109973A HK 1068332 A1 HK1068332 A1 HK 1068332A1
Authority
HK
Hong Kong
Prior art keywords
ace
nep
inhibitors
sub
pyrane derivatives
Prior art date
Application number
HK04109973A
Other languages
English (en)
Inventor
Cynthia Anne Fink
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1068332A1 publication Critical patent/HK1068332A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK04109973A 2001-09-21 2004-12-15 Pyrane derivatives as both ace-and nep-inhibitors HK1068332A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32382501P 2001-09-21 2001-09-21
PCT/EP2002/010608 WO2003027091A1 (en) 2001-09-21 2002-09-20 Pyrane derivatives as both ace- and nep- inhibitors

Publications (1)

Publication Number Publication Date
HK1068332A1 true HK1068332A1 (en) 2005-04-29

Family

ID=23260883

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04109973A HK1068332A1 (en) 2001-09-21 2004-12-15 Pyrane derivatives as both ace-and nep-inhibitors

Country Status (12)

Country Link
US (2) US7071169B2 (xx)
EP (1) EP1430045B1 (xx)
JP (1) JP4263095B2 (xx)
CN (1) CN1304415C (xx)
AT (1) ATE342261T1 (xx)
BR (1) BR0212899A (xx)
CA (1) CA2456281A1 (xx)
DE (1) DE60215368T2 (xx)
ES (1) ES2274106T3 (xx)
HK (1) HK1068332A1 (xx)
PT (1) PT1430045E (xx)
WO (1) WO2003027091A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1304415C (zh) 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
FI20040674A0 (fi) * 2004-05-12 2004-05-12 Orion Corp Menetelmä tromboembolisten sairauksien estoon
WO2006064016A1 (en) * 2004-12-15 2006-06-22 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and hmg coa reductase inhibitors
DE602006013792D1 (de) * 2005-02-18 2010-06-02 Solvay Pharm Gmbh Pharmazeutische zusammensetzungen mit nep-inhibitoren, inhibitoren des endogenes endothelin produzierenden systems und diuretika
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
EP1897879A3 (en) 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-substituted piperidines as renin inhibitors
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
ATE509941T1 (de) * 2006-01-11 2011-06-15 Seikagaku Kogyo Co Ltd Cycloalkylcarbonylaminosäureester-derivat und herstellungsverfahren dafür
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
WO2009026517A2 (en) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapy for complications of diabetes
WO2009127251A1 (en) * 2008-04-16 2009-10-22 Novartis Ag Combinations comprising a renin inhibitor
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211648A (ja) * 1990-07-27 1992-08-03 Nippon Kayaku Co Ltd ケト酸アミド誘導体
US5432186A (en) 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
DE69424846T2 (de) 1993-11-16 2000-11-16 Novartis Ag Zyklische Aminosäure-Derivate mit ACE und NEP inhibierender Aktivität
SK15812000A3 (sk) * 1998-04-23 2001-03-12 Novartis Ag Inhibítory enzýmu na premenu endotelínu
AU750048B2 (en) 1998-04-23 2002-07-11 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
WO2001077095A2 (en) 2000-04-06 2001-10-18 Novartis Ag Derivatives of alpha-mercaptoacetamide
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CN1304415C (zh) 2001-09-21 2007-03-14 诺瓦提斯公司 作为ace和nep抑制剂的吡喃衍生物

Also Published As

Publication number Publication date
CA2456281A1 (en) 2003-04-03
CN1304415C (zh) 2007-03-14
ATE342261T1 (de) 2006-11-15
ES2274106T3 (es) 2007-05-16
EP1430045B1 (en) 2006-10-11
PT1430045E (pt) 2007-01-31
EP1430045A1 (en) 2004-06-23
US20060194742A1 (en) 2006-08-31
DE60215368T2 (de) 2007-08-16
BR0212899A (pt) 2004-11-03
CN1555372A (zh) 2004-12-15
JP4263095B2 (ja) 2009-05-13
WO2003027091A1 (en) 2003-04-03
JP2005504099A (ja) 2005-02-10
US7071169B2 (en) 2006-07-04
DE60215368D1 (de) 2006-11-23
US20040266698A1 (en) 2004-12-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100920