BR0314759A - Derivados de pirazol - Google Patents

Derivados de pirazol

Info

Publication number
BR0314759A
BR0314759A BR0314759-2A BR0314759A BR0314759A BR 0314759 A BR0314759 A BR 0314759A BR 0314759 A BR0314759 A BR 0314759A BR 0314759 A BR0314759 A BR 0314759A
Authority
BR
Brazil
Prior art keywords
sup
compounds
preparation
reverse transcriptase
present
Prior art date
Application number
BR0314759-2A
Other languages
English (en)
Inventor
Lyn Howard Jones
Charles Eric Mowbray
David Anthony Price
Matthew Duncan Selby
Paul Anthony Stupple
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0223357A external-priority patent/GB0223357D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR0314759A publication Critical patent/BR0314759A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

"DERIVADOS DE PIRAZOL". A presente invenção refere-se a derivados de pirazol de fórmula ou seus sais, solvatos ou derivados farmaceuticamente aceitáveis, em que R^ 1^ a R^ 4^, n, W, X e Y são definidos na descrição, e a processos para a sua preparação, intermediários usados na sua preparação, composições que os contêm e aos usos de tais derivados. Os compostos da presente invenção ligam-se à enzima transcriptase reversa e são seus moduladores, especialmente inibidores. Como tal, os compostos da presente invenção são úteis no tratamento de uma variedade de desordens incluindo aquelas nas quais a inibição de transcriptase reversa está implicada. As desordens de interesse incluem as causadas por Vírus da Imunodeficiência Humana (HIV) e retrovírus geneticamente relacionados, tais como Síndrome da lmunodeficiência Adquirida (AIDS).
BR0314759-2A 2002-09-26 2003-09-15 Derivados de pirazol BR0314759A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0222375 2002-09-26
GB0223357A GB0223357D0 (en) 2002-10-08 2002-10-08 Chemical compounds
PCT/IB2003/004071 WO2004029051A1 (en) 2002-09-26 2003-09-15 Pyrazole amides for treating hiv infections

Publications (1)

Publication Number Publication Date
BR0314759A true BR0314759A (pt) 2005-07-26

Family

ID=32044463

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314759-2A BR0314759A (pt) 2002-09-26 2003-09-15 Derivados de pirazol

Country Status (11)

Country Link
US (1) US7157468B2 (pt)
EP (1) EP1556381B1 (pt)
JP (1) JP2006505625A (pt)
AT (1) ATE386741T1 (pt)
AU (1) AU2003263455A1 (pt)
BR (1) BR0314759A (pt)
CA (1) CA2495338A1 (pt)
DE (1) DE60319254T2 (pt)
ES (1) ES2298615T3 (pt)
MX (1) MXPA05002004A (pt)
WO (1) WO2004029051A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2057125E (pt) 2006-08-16 2011-05-31 Hoffmann La Roche Inibidores n?o nucle?sidos de transcriptase inversa
CN101784529A (zh) 2007-06-22 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的脲和氨基甲酸酯衍生物
FI3640241T3 (fi) 2013-10-18 2023-01-13 Bromodomeeni-inhibiittorit
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
WO2017184462A1 (en) 2016-04-18 2017-10-26 Celgene Quanticel Research, Inc. Therapeutic compounds
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303200A (en) * 1963-11-05 1967-02-07 American Home Prod Pyrazole-1-ethanol derivatives
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
GB2233578A (en) 1989-07-01 1991-01-16 Edwards & Jones Filtering yeast slurry
US5028322A (en) 1989-07-11 1991-07-02 The Graver Company Low profile underdrain strainer assembly with improved distribution/fastening means
NZ325248A (en) 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
GB9700504D0 (en) 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
GB0016787D0 (en) * 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
GB0024795D0 (en) 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases
US6933312B2 (en) * 2002-10-07 2005-08-23 Agouron Pharmaceuticals, Inc. Pyrazole derivatives

Also Published As

Publication number Publication date
WO2004029051A1 (en) 2004-04-08
EP1556381A1 (en) 2005-07-27
MXPA05002004A (es) 2005-04-28
DE60319254T2 (de) 2009-02-12
US20050004129A1 (en) 2005-01-06
JP2006505625A (ja) 2006-02-16
ATE386741T1 (de) 2008-03-15
AU2003263455A1 (en) 2004-04-19
US7157468B2 (en) 2007-01-02
EP1556381B1 (en) 2008-02-20
CA2495338A1 (en) 2004-04-08
DE60319254D1 (de) 2008-04-03
ES2298615T3 (es) 2008-05-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.