ATE374775T1 - Inhibitoren des hiv-integrase-enzyms - Google Patents
Inhibitoren des hiv-integrase-enzymsInfo
- Publication number
- ATE374775T1 ATE374775T1 AT05718436T AT05718436T ATE374775T1 AT E374775 T1 ATE374775 T1 AT E374775T1 AT 05718436 T AT05718436 T AT 05718436T AT 05718436 T AT05718436 T AT 05718436T AT E374775 T1 ATE374775 T1 AT E374775T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme inhibitors
- integrase enzyme
- hiv integrase
- hiv
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56572804P | 2004-04-26 | 2004-04-26 | |
US64331605P | 2005-01-11 | 2005-01-11 | |
US65759405P | 2005-02-28 | 2005-02-28 | |
US66043005P | 2005-03-09 | 2005-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE374775T1 true ATE374775T1 (de) | 2007-10-15 |
Family
ID=34964479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05718436T ATE374775T1 (de) | 2004-04-26 | 2005-04-13 | Inhibitoren des hiv-integrase-enzyms |
Country Status (10)
Country | Link |
---|---|
US (2) | US7692014B2 (de) |
EP (1) | EP1751157B1 (de) |
JP (1) | JP2007534738A (de) |
AT (1) | ATE374775T1 (de) |
BR (1) | BRPI0510306A (de) |
CA (1) | CA2563761C (de) |
DE (1) | DE602005002746T2 (de) |
ES (1) | ES2292123T3 (de) |
MX (1) | MXPA06012342A (de) |
WO (1) | WO2005103051A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
EP1756103A2 (de) | 2004-04-26 | 2007-02-28 | Pfizer, Inc. | Pyrrolopyridinderivate und deren verwendung als inhibitoren der hiv-integrase |
BRPI0510306A (pt) | 2004-04-26 | 2007-09-04 | Pfizer | inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso |
EA200800758A1 (ru) * | 2005-10-07 | 2008-08-29 | Пфайзер Продактс Инк. | Ингибиторы фермента интегразы вич |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ194747A (en) | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
GB8720125D0 (en) | 1987-08-26 | 1987-09-30 | Roussel Lab Ltd | Chemical compounds |
HU212435B (en) * | 1990-06-07 | 1996-06-28 | Sandoz Ag | Herbicidal compositions containing substituted phthalides and heterocyclic phthalides as active ingredient and process for preparation of their active ingredients. |
CA2114728A1 (en) | 1991-08-08 | 1993-02-18 | Tetsuro Ikekawa | Carcinostatic compound and production thereof |
ES2125976T3 (es) * | 1992-03-20 | 1999-03-16 | Wellcome Found | Otros derivados de indol con accion antiviral. |
GB2271566A (en) | 1992-10-14 | 1994-04-20 | Merck & Co Inc | HIV integrase inhibitors |
AU7225494A (en) | 1993-07-19 | 1995-02-20 | Zelin Li | Qinghaosu derivatives against aids |
GB2306476A (en) | 1995-10-27 | 1997-05-07 | Merck & Co Inc | Hiv integrase inhibitors |
US6057297A (en) * | 1996-08-06 | 2000-05-02 | Polifarma S.P.A. | Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof |
FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
EP0949926A4 (de) | 1996-10-31 | 2001-01-17 | Merck & Co Inc | Benzodiazepin hydrozidderivate als hiv-interase inhibitoren |
GB2327674A (en) | 1997-07-29 | 1999-02-03 | Merck & Co Inc | HIV integrase inhibitors |
US6403347B1 (en) * | 1998-02-03 | 2002-06-11 | Merck & Co., Inc. | HIV integrase inhibitors |
AU761020B2 (en) | 1998-06-12 | 2003-05-29 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Beta-carboline compounds |
DE60035591D1 (de) * | 1999-05-12 | 2007-08-30 | Us Health | Thiazepin-hemmer von hiv-1 integrase |
US6245806B1 (en) * | 1999-08-03 | 2001-06-12 | Merck & Co., Inc. | HIV integrase inhibitors |
WO2001027309A1 (en) * | 1999-10-13 | 2001-04-19 | Merck & Co., Inc. | Hiv integrase inhibitors |
EP1209158A1 (de) | 2000-11-18 | 2002-05-29 | Aventis Pharma Deutschland GmbH | Substitutierte beta-Carboline |
AU2001266991A1 (en) * | 2000-06-16 | 2002-01-02 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
WO2002002516A2 (en) | 2000-06-30 | 2002-01-10 | Thomas Jefferson University | Inhibitors of hiv integrase |
WO2002070491A1 (fr) | 2001-03-01 | 2002-09-12 | Shionogi & Co., Ltd. | Derive a noyau heteroaromatique azote presentant une activite d'inhibiteur d'integrase du vih |
EP1375486B1 (de) | 2001-03-01 | 2008-10-15 | Shionogi & Co., Ltd. | Stickstoffhaltige heteroarylverbindungen mit hiv-integrase inhibierender wirkung |
JP2003171381A (ja) | 2001-09-25 | 2003-06-20 | Takeda Chem Ind Ltd | エントリー阻害剤 |
JP2003119137A (ja) | 2001-10-10 | 2003-04-23 | Japan Tobacco Inc | Hiv阻害剤 |
DE60216952T2 (de) | 2001-10-19 | 2007-07-05 | Transtech Pharma Inc. | Beta-carbolin-derivate als ptp-inhibitoren |
CA2463975A1 (en) | 2001-10-26 | 2003-05-01 | Maria Emilia Di Francesco | Dihydroxypyrimidine carboxamide inhibitors of hiv integrase |
JP4497347B2 (ja) | 2001-12-05 | 2010-07-07 | 塩野義製薬株式会社 | Hivインテグラーゼ阻害活性を有する誘導体 |
RU2284315C2 (ru) | 2001-12-12 | 2006-09-27 | Бристол-Маерс Сквибб Компани | Ингибиторы вич-интегразы и содержащие их фармацевтические композиции |
CA2472372C (en) | 2002-01-17 | 2010-08-17 | Melissa Egbertson | Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors |
CA2478310A1 (en) | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors |
WO2003082881A2 (en) * | 2002-03-28 | 2003-10-09 | Procyon Biopharma Inc. | Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors |
EP1499391A2 (de) | 2002-04-10 | 2005-01-26 | Merck & Co., Inc. | Pharmazeutische zusammensetzungen mit einem hiv-integrase-hemmer und einem nichtionischen tensid |
AU2002335027A1 (en) | 2002-10-15 | 2004-05-04 | Chiron Corporation | Treatment of tnf-alpha-mediated disorders with casein kinase i epsilon inhibitors |
PA8586801A1 (es) * | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
CA2513141A1 (en) * | 2003-01-27 | 2004-08-12 | Pfizer Inc. | Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use |
BRPI0510306A (pt) | 2004-04-26 | 2007-09-04 | Pfizer | inibidores da enzima de hiv integrase,composição farmacêutica contendo os referidos inibidores bem como seu uso |
EP1756103A2 (de) * | 2004-04-26 | 2007-02-28 | Pfizer, Inc. | Pyrrolopyridinderivate und deren verwendung als inhibitoren der hiv-integrase |
US20070232644A1 (en) | 2004-09-07 | 2007-10-04 | Pfizer Inc. | Inhibitors of the Hiv Integrase Enzyme |
CA2623534A1 (en) | 2005-10-03 | 2007-04-12 | Pfizer Products Inc. | Inhibitors of the hiv integrase enzyme |
EA200800758A1 (ru) * | 2005-10-07 | 2008-08-29 | Пфайзер Продактс Инк. | Ингибиторы фермента интегразы вич |
-
2005
- 2005-04-13 BR BRPI0510306-1A patent/BRPI0510306A/pt not_active Application Discontinuation
- 2005-04-13 EP EP05718436A patent/EP1751157B1/de not_active Not-in-force
- 2005-04-13 CA CA002563761A patent/CA2563761C/en not_active Expired - Fee Related
- 2005-04-13 ES ES05718436T patent/ES2292123T3/es active Active
- 2005-04-13 AT AT05718436T patent/ATE374775T1/de not_active IP Right Cessation
- 2005-04-13 WO PCT/IB2005/000976 patent/WO2005103051A1/en active IP Right Grant
- 2005-04-13 JP JP2007510137A patent/JP2007534738A/ja active Pending
- 2005-04-13 MX MXPA06012342A patent/MXPA06012342A/es not_active Application Discontinuation
- 2005-04-13 DE DE602005002746T patent/DE602005002746T2/de active Active
- 2005-04-25 US US11/114,813 patent/US7692014B2/en not_active Expired - Fee Related
-
2010
- 2010-02-01 US US12/697,513 patent/US20100137283A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA06012342A (es) | 2007-01-17 |
JP2007534738A (ja) | 2007-11-29 |
DE602005002746T2 (de) | 2008-02-07 |
CA2563761C (en) | 2009-12-29 |
US20050277661A1 (en) | 2005-12-15 |
ES2292123T3 (es) | 2008-03-01 |
EP1751157A1 (de) | 2007-02-14 |
DE602005002746D1 (de) | 2007-11-15 |
US7692014B2 (en) | 2010-04-06 |
BRPI0510306A (pt) | 2007-09-04 |
EP1751157B1 (de) | 2007-10-03 |
WO2005103051A1 (en) | 2005-11-03 |
CA2563761A1 (en) | 2005-11-03 |
US20100137283A1 (en) | 2010-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |