EA202192111A1 - Новые тритерпеновые производные в качестве ингибиторов вич - Google Patents

Новые тритерпеновые производные в качестве ингибиторов вич

Info

Publication number
EA202192111A1
EA202192111A1 EA202192111A EA202192111A EA202192111A1 EA 202192111 A1 EA202192111 A1 EA 202192111A1 EA 202192111 A EA202192111 A EA 202192111A EA 202192111 A EA202192111 A EA 202192111A EA 202192111 A1 EA202192111 A1 EA 202192111A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triterpene derivatives
hiv inhibitors
new triterpene
new
relates
Prior art date
Application number
EA202192111A
Other languages
English (en)
Inventor
Партасарадхи Редди Банди
Ратнакар Редди Кура
Пандуранга Редди Адулла
Бхаскар Редди Касиредди
Original Assignee
Хетеро Лабс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хетеро Лабс Лимитед filed Critical Хетеро Лабс Лимитед
Publication of EA202192111A1 publication Critical patent/EA202192111A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Настоящее изобретение относится к новым тритерпеновым производным формулы (I); и их фармацевтически приемлемым солям, где R1, R2, R3, R4 и кольцо имеют значения, как определено в данном описании. Изобретение также относится к новым тритерпеновым производным, родственным соединениям и фармацевтическим композициям, применимым для терапевтического лечения вирусных заболеваний и конкретно заболеваний, опосредованных ВИЧ.
EA202192111A 2019-02-11 2020-02-11 Новые тритерпеновые производные в качестве ингибиторов вич EA202192111A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201941005217 2019-02-11
PCT/IB2020/051048 WO2020165741A1 (en) 2019-02-11 2020-02-11 Novel triterpene derivatives as hiv inhibitors

Publications (1)

Publication Number Publication Date
EA202192111A1 true EA202192111A1 (ru) 2022-01-26

Family

ID=70416451

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192111A EA202192111A1 (ru) 2019-02-11 2020-02-11 Новые тритерпеновые производные в качестве ингибиторов вич

Country Status (23)

Country Link
US (1) US20220177439A1 (ru)
EP (2) EP4248960A3 (ru)
JP (1) JP2022520384A (ru)
KR (1) KR20210127955A (ru)
CN (1) CN113727989B (ru)
AU (1) AU2020222299C1 (ru)
BR (1) BR112021015762A2 (ru)
CA (1) CA3129743A1 (ru)
DK (1) DK3924361T3 (ru)
EA (1) EA202192111A1 (ru)
ES (1) ES2965305T3 (ru)
FI (1) FI3924361T3 (ru)
HR (1) HRP20231582T1 (ru)
HU (1) HUE064262T2 (ru)
IL (1) IL285487A (ru)
LT (1) LT3924361T (ru)
MX (1) MX2021009584A (ru)
PL (1) PL3924361T3 (ru)
PT (1) PT3924361T (ru)
RS (1) RS64915B1 (ru)
SI (1) SI3924361T1 (ru)
WO (1) WO2020165741A1 (ru)
ZA (1) ZA202106037B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023513331A (ja) * 2020-02-11 2023-03-30 ヘテロ ラボズ リミテッド Ｈｉｖ阻害剤としての新規トリテルペン誘導体

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152815A (ja) 1982-03-05 1983-09-10 Tamio Nishimura 医療用抗ウイルス剤
AU699168B2 (en) 1993-07-09 1998-11-26 University Of Pittsburgh Selection and use of antiviral peptides
US6399654B1 (en) 1995-06-23 2002-06-04 Advanced Life Sciences, Inc. Biflavanoids and derivatives thereof as antiviral agents
HUP9701080A3 (en) 1997-06-23 1999-05-28 Gene Res Lab Inc New York N Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative
US6427248B1 (en) 1997-10-09 2002-08-06 David M. Albert Grip-enhancing glove
AU7268000A (en) 1999-07-21 2001-02-13 Martin Heinkelein Method for quantization of the antiviral effect of antiviral active principles
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
AR063546A1 (es) * 2006-11-03 2009-01-28 Panacos Pharmaceuticals Inc DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH.
CN104844678B (zh) 2007-05-11 2018-02-09 香港科技大学 具有神经保护和增强记忆活性的受体调节剂
CN101367861A (zh) 2007-08-15 2009-02-18 中国药科大学 2-羟基-3-脱氧五环三萜类化合物及其衍生物、其制备方法及用途
AU2009214779A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17beta lupane derivatives
CN102164942B (zh) 2008-09-19 2017-02-15 生物科技研究有限公司 三萜系化合物及其使用的方法
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
CN102399254A (zh) 2010-09-07 2012-04-04 中国药科大学 新型五环三萜衍生物、其制备方法及用途
CN103429607B (zh) 2011-01-31 2016-02-17 百时美施贵宝公司 具有hiv成熟抑制活性的c-17和c-3经修饰的三萜系化合物
WO2013020245A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
KR20130028442A (ko) 2011-09-09 2013-03-19 학교법인 한동대학교 항노화 활성을 갖는 베툴린산과 그 유도체 및 이를 함유하는 조성물
EA023463B1 (ru) * 2011-09-21 2016-06-30 Бристол-Майерс Сквибб Компани Производные бетулиновой кислоты с противовирусной активностью
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
WO2013160810A2 (en) 2012-04-24 2013-10-31 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
SG11201505639SA (en) 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity
AU2014218754B2 (en) 2013-02-25 2017-04-20 VIIV Healthcare UK (No.5) Limited C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of HIV
WO2017017630A1 (en) * 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017149518A1 (en) * 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
JP2023513331A (ja) * 2020-02-11 2023-03-30 ヘテロ ラボズ リミテッド Ｈｉｖ阻害剤としての新規トリテルペン誘導体

Also Published As

Publication number Publication date
US20220177439A1 (en) 2022-06-09
RS64915B1 (sr) 2023-12-29
WO2020165741A1 (en) 2020-08-20
ZA202106037B (en) 2022-05-25
CN113727989B (zh) 2024-02-13
JP2022520384A (ja) 2022-03-30
BR112021015762A2 (pt) 2021-10-05
PT3924361T (pt) 2023-12-12
HRP20231582T1 (hr) 2024-03-15
AU2020222299B2 (en) 2024-02-08
CA3129743A1 (en) 2020-08-20
IL285487A (en) 2021-09-30
CN113727989A (zh) 2021-11-30
KR20210127955A (ko) 2021-10-25
EP4248960A2 (en) 2023-09-27
EP3924361A1 (en) 2021-12-22
EP4248960A3 (en) 2024-01-03
PL3924361T3 (pl) 2024-03-18
SI3924361T1 (sl) 2024-02-29
HUE064262T2 (hu) 2024-02-28
FI3924361T3 (fi) 2023-12-11
MX2021009584A (es) 2021-09-23
DK3924361T3 (da) 2023-11-13
LT3924361T (lt) 2023-12-27
AU2020222299C1 (en) 2024-05-16
AU2020222299A1 (en) 2021-10-07
EP3924361B1 (en) 2023-09-06
ES2965305T3 (es) 2024-04-12

Similar Documents

Publication Publication Date Title
MX2022005839A (es) Compuestos utiles como inhibidores de la proteina helios.
DOP2022000278A (es) Inhibidores de cisteína proteasas y sus métodos de uso
CR20210627A (es) Derivados de benzisoxazol sulfonimada
EA202090530A1 (ru) Производные 1-бензил-2-имино-4-фенил-5-оксоимидазолидина как ингибиторы протеазы вич
EA201890200A1 (ru) Производные циклизированного сульфамоилариламида и их применение в качестве лекарственных препаратов для лечения гепатита b
EA201891103A1 (ru) Композиции для лечения спинальной мышечной атрофии
IL180495A (en) Benzyl triazolone compounds as non-nucleotide reverse transcriptase inhibitors
EA201000830A1 (ru) Производные пиримидина для лечения астмы, хобл, аллергического ринита, аллергического конъюнктивита, атопического дерматита, рака, гепатита в, гепатита с, вич, впч, бактериальных инфекций и дерматоза
ATE440834T1 (de) Substituierte arylaminderivate und verwendungsverfahren
EA201791872A1 (ru) Полициклические карбамоилпиридоновые соединения и их фармацевтическое применение
EA202190854A1 (ru) Ингибиторы репликации вируса иммунодефицита человека
EA201270492A1 (ru) Соединения для лечения дислипидемии и связанных с ней заболеваний
MX2021003945A (es) Compuestos de indolinona para uso como inhibidores de map4k1.
CR20200413A (es) Inhibidores de canal de potencial de receptor transitorio de oxadiazol
EA202192512A1 (ru) Пиримидоновые производные с конденсированными кольцами для применения в лечении инфекции, вызванной hbv, или заболеваний, вызванных hbv
EA202192900A1 (ru) Модуляторы пути интегрированной реакции на стресс
EA202192905A1 (ru) Соединения, содержащие n-метил-2-пиридон, и фармацевтически приемлемые соли
PH12021551232A1 (en) Haloallylamine compounds and application thereof
CO2022012884A2 (es) Compuestos de amino pirimidina fusionados
EA201101655A8 (ru) Производные нитрила, их использование в фармацевтических целях и в композициях
EA201891649A1 (ru) C-3 и c-17 модифицированные тритерпеноиды в качестве ингибиторов вич-1
EA202192111A1 (ru) Новые тритерпеновые производные в качестве ингибиторов вич
CL2023000418A1 (es) Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmacéuticos de los mismos
EA202190046A1 (ru) N-замещенные производные тетрагидротиенопиридина и их применение
ATE374775T1 (de) Inhibitoren des hiv-integrase-enzyms