EA202192111A1 - Новые тритерпеновые производные в качестве ингибиторов вич - Google Patents

Новые тритерпеновые производные в качестве ингибиторов вич

Info

Publication number
EA202192111A1
EA202192111A1 EA202192111A EA202192111A EA202192111A1 EA 202192111 A1 EA202192111 A1 EA 202192111A1 EA 202192111 A EA202192111 A EA 202192111A EA 202192111 A EA202192111 A EA 202192111A EA 202192111 A1 EA202192111 A1 EA 202192111A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triterpene derivatives
hiv inhibitors
new triterpene
new
relates
Prior art date
Application number
EA202192111A
Other languages
English (en)
Inventor
Партасарадхи Редди Банди
Ратнакар Редди Кура
Пандуранга Редди Адулла
Бхаскар Редди Касиредди
Original Assignee
Хетеро Лабс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хетеро Лабс Лимитед filed Critical Хетеро Лабс Лимитед
Publication of EA202192111A1 publication Critical patent/EA202192111A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Настоящее изобретение относится к новым тритерпеновым производным формулы (I); и их фармацевтически приемлемым солям, где R1, R2, R3, R4 и кольцо имеют значения, как определено в данном описании. Изобретение также относится к новым тритерпеновым производным, родственным соединениям и фармацевтическим композициям, применимым для терапевтического лечения вирусных заболеваний и конкретно заболеваний, опосредованных ВИЧ.
EA202192111A 2019-02-11 2020-02-11 Новые тритерпеновые производные в качестве ингибиторов вич EA202192111A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201941005217 2019-02-11
PCT/IB2020/051048 WO2020165741A1 (en) 2019-02-11 2020-02-11 Novel triterpene derivatives as hiv inhibitors

Publications (1)

Publication Number Publication Date
EA202192111A1 true EA202192111A1 (ru) 2022-01-26

Family

ID=70416451

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192111A EA202192111A1 (ru) 2019-02-11 2020-02-11 Новые тритерпеновые производные в качестве ингибиторов вич

Country Status (23)

Country Link
US (1) US20220177439A1 (ru)
EP (2) EP4248960A3 (ru)
JP (1) JP2022520384A (ru)
KR (1) KR20210127955A (ru)
CN (1) CN113727989B (ru)
AU (1) AU2020222299C1 (ru)
BR (1) BR112021015762A2 (ru)
CA (1) CA3129743A1 (ru)
DK (1) DK3924361T3 (ru)
EA (1) EA202192111A1 (ru)
ES (1) ES2965305T3 (ru)
FI (1) FI3924361T3 (ru)
HR (1) HRP20231582T1 (ru)
HU (1) HUE064262T2 (ru)
IL (1) IL285487A (ru)
LT (1) LT3924361T (ru)
MX (1) MX2021009584A (ru)
PL (1) PL3924361T3 (ru)
PT (1) PT3924361T (ru)
RS (1) RS64915B1 (ru)
SI (1) SI3924361T1 (ru)
WO (1) WO2020165741A1 (ru)
ZA (1) ZA202106037B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103579A4 (en) * 2020-02-11 2024-05-01 Hetero Labs Limited NOVEL TRITEPENDENT DERIVATIVES AS HIV INHIBITORS

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JPS58152815A (ja) 1982-03-05 1983-09-10 Tamio Nishimura 医療用抗ウイルス剤
WO1995002071A1 (en) 1993-07-09 1995-01-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Selection and use of antiviral peptides
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WO2001007646A2 (de) 1999-07-21 2001-02-01 Martin Heinkelein Verfahren zur quantifizierung der antiviralen wirkung antiviraler wirkstoffe
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WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
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SG192144A1 (en) 2011-01-31 2013-08-30 Bristol Myers Squibb Co C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
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WO2013043778A1 (en) * 2011-09-21 2013-03-28 Bristol-Myers Squibb Company Novel betulinic acid derivatives with antiviral activity
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WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
SG11201505639SA (en) 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity
KR20150121712A (ko) 2013-02-25 2015-10-29 브리스톨-마이어스 스큅 컴퍼니 Hiv의 치료에 유용한 c-3 알킬 및 알케닐 개질된 베툴린산 유도체
WO2017017630A1 (en) * 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017149518A1 (en) * 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
EP4103579A4 (en) * 2020-02-11 2024-05-01 Hetero Labs Limited NOVEL TRITEPENDENT DERIVATIVES AS HIV INHIBITORS

Also Published As

Publication number Publication date
FI3924361T3 (fi) 2023-12-11
EP4248960A3 (en) 2024-01-03
CN113727989B (zh) 2024-02-13
IL285487A (en) 2021-09-30
WO2020165741A1 (en) 2020-08-20
EP4248960A2 (en) 2023-09-27
ZA202106037B (en) 2022-05-25
HUE064262T2 (hu) 2024-02-28
BR112021015762A2 (pt) 2021-10-05
LT3924361T (lt) 2023-12-27
AU2020222299B2 (en) 2024-02-08
CN113727989A (zh) 2021-11-30
AU2020222299C1 (en) 2024-05-16
KR20210127955A (ko) 2021-10-25
JP2022520384A (ja) 2022-03-30
PT3924361T (pt) 2023-12-12
RS64915B1 (sr) 2023-12-29
EP3924361B1 (en) 2023-09-06
CA3129743A1 (en) 2020-08-20
DK3924361T3 (da) 2023-11-13
ES2965305T3 (es) 2024-04-12
MX2021009584A (es) 2021-09-23
PL3924361T3 (pl) 2024-03-18
EP3924361A1 (en) 2021-12-22
HRP20231582T1 (hr) 2024-03-15
US20220177439A1 (en) 2022-06-09
SI3924361T1 (sl) 2024-02-29
AU2020222299A1 (en) 2021-10-07

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