SG11201505639SA - C-19 modified triterpenoids with hiv maturation inhibitory activity - Google Patents

C-19 modified triterpenoids with hiv maturation inhibitory activity

Info

Publication number
SG11201505639SA
SG11201505639SA SG11201505639SA SG11201505639SA SG11201505639SA SG 11201505639S A SG11201505639S A SG 11201505639SA SG 11201505639S A SG11201505639S A SG 11201505639SA SG 11201505639S A SG11201505639S A SG 11201505639SA SG 11201505639S A SG11201505639S A SG 11201505639SA
Authority
SG
Singapore
Prior art keywords
inhibitory activity
hiv maturation
maturation inhibitory
modified triterpenoids
triterpenoids
Prior art date
Application number
SG11201505639SA
Inventor
Jacob Swidorski
Brian Lee Venables
Zheng Liu
Ny Sin
Nicholas A Meanwell
Alicia Regueiro-Ren
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG11201505639SA publication Critical patent/SG11201505639SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201505639SA 2013-02-06 2014-02-04 C-19 modified triterpenoids with hiv maturation inhibitory activity SG11201505639SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361761403P 2013-02-06 2013-02-06
PCT/US2014/014647 WO2014123889A1 (en) 2013-02-06 2014-02-04 C-19 modified triterpenoids with hiv maturation inhibitory activity

Publications (1)

Publication Number Publication Date
SG11201505639SA true SG11201505639SA (en) 2015-08-28

Family

ID=50150818

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505639SA SG11201505639SA (en) 2013-02-06 2014-02-04 C-19 modified triterpenoids with hiv maturation inhibitory activity

Country Status (15)

Country Link
US (1) US20140221361A1 (en)
EP (1) EP2953960A1 (en)
JP (1) JP6186010B2 (en)
KR (1) KR20150115881A (en)
CN (1) CN105121454A (en)
AR (1) AR094684A1 (en)
AU (1) AU2014215468B2 (en)
BR (1) BR112015018491A2 (en)
CA (1) CA2900124A1 (en)
EA (1) EA027371B1 (en)
IL (1) IL240289A0 (en)
MX (1) MX2015010003A (en)
SG (1) SG11201505639SA (en)
TW (1) TW201443073A (en)
WO (1) WO2014123889A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
RU2018105343A (en) 2015-07-28 2019-08-28 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Betulin derivatives for the prevention or treatment of HIV infections
BR112018001537A2 (en) 2015-07-28 2018-09-18 Glaxosmithkline Ip No 2 Ltd pharmaceutically acceptable compound or salt thereof, pharmaceutical composition, methods for treating and preventing an HIV infection in an individual, and use of a compound or salt
WO2017025901A1 (en) * 2015-08-11 2017-02-16 Hetero Research Foundation Novel c28-analogues with c3-modifications of triterpene derivatives as hiv inhibitors
AU2016327169A1 (en) 2015-09-24 2018-04-12 Glaxosmithkline Intellectual Property (No.2) Limited Compounds with hiv maturation inhibitory activity
US20190023733A1 (en) 2016-01-20 2019-01-24 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (en) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD TRITERPENOIDS MODIFIED IN C-3 AND C-17 AS HIV-1 INHIBITORS
WO2017149518A1 (en) * 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
ES2836402T3 (en) 2016-06-30 2021-06-25 Viiv Healthcare Uk No 5 Ltd Azadecalin derivatives as inhibitors of human immunodeficiency virus replication
WO2018044853A1 (en) * 2016-08-31 2018-03-08 Viiv Healthcare Conpany Combinations and uses and treatments thereof
US20190183901A1 (en) * 2016-08-31 2019-06-20 Viiv Healthcare Company Combinations and uses and treatments thereof
EP4321164A3 (en) 2018-04-24 2024-04-17 ViiV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
EP3796900A4 (en) 2018-06-29 2022-03-30 DFH Therapeutics Triterpene amine derivatives
PT3924361T (en) 2019-02-11 2023-12-12 Hetero Labs Ltd Novel triterpene derivatives as hiv inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2694048B2 (en) * 1991-05-09 1997-12-24 日立建機株式会社 Hydraulic drive for construction machinery
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
FR2683531B1 (en) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa NEW LUPANE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20020137755A1 (en) 2000-12-04 2002-09-26 Bilodeau Mark T. Tyrosine kinase inhibitors
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
EP1730163A4 (en) 2004-03-17 2009-12-30 Panacos Pharmaceuticals Inc Pharmaceuticals salts of 3-o-(3,3-dimethylsuccinyl) betulinic acid
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20090105203A1 (en) 2006-10-16 2009-04-23 Myriad Genetics, Incorporated Compounds for treating viral infections
WO2009100532A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. NOVEL 17ß LUPANE DERIVATIVES
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
ES2612452T3 (en) * 2010-06-04 2017-05-17 VIIV Healthcare UK (No.5) Limited C-3 modified betulinic acid derivatives as inhibitors of HIV maturation
RS54239B1 (en) 2010-06-04 2015-12-31 Bristol-Myers Squibb Company C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors
WO2012006190A1 (en) 2010-06-29 2012-01-12 Huawei Technologies Co., Ltd. Delegate gateways and proxy for target hosts in large layer 2 and address resolution with duplicated internet protocol addresses
EP2670764B1 (en) 2011-01-31 2015-09-02 Bristol-Myers Squibb Company C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US20150119373A1 (en) * 2012-04-24 2015-04-30 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity

Also Published As

Publication number Publication date
MX2015010003A (en) 2015-10-30
CA2900124A1 (en) 2014-08-14
EA027371B1 (en) 2017-07-31
JP2016507558A (en) 2016-03-10
BR112015018491A2 (en) 2017-07-18
CN105121454A (en) 2015-12-02
WO2014123889A1 (en) 2014-08-14
KR20150115881A (en) 2015-10-14
AR094684A1 (en) 2015-08-19
AU2014215468B2 (en) 2017-05-18
US20140221361A1 (en) 2014-08-07
EP2953960A1 (en) 2015-12-16
EA201591406A1 (en) 2015-12-30
AU2014215468A1 (en) 2015-09-24
TW201443073A (en) 2014-11-16
JP6186010B2 (en) 2017-08-23
IL240289A0 (en) 2015-09-24

Similar Documents

Publication Publication Date Title
IL240289A0 (en) C-19 modified triterpenoids with hiv maturation inhibitory activity
IL243445B (en) Silencer
HK1204608A1 (en) C-3 cycloalkenyl triterpenoids with hiv maturation inhibitory activity hiv c-3
HK1219427A1 (en) Complex
ZA201508187B (en) Catalyst
GB201308131D0 (en) Ophthalmoscope
GB201318846D0 (en) Photocatalysts
TWM475794U (en) Stud
EP2951761A4 (en) Activity graphs
GB201302016D0 (en) Catalyst
EP2987979A4 (en) Muffler cutter
HK1188365A2 (en) Activity center
HK1219632A1 (en) Needle driver
EP2992813A4 (en) Liquid-testing implement
AU351108S (en) Dough hook
EP2952799A4 (en) Pipe-reinforcing implement
GB2511396B (en) Pre-turbocharger catalyst
PT2999815T (en) Sliding-tongue needle
EP2977005C0 (en) Needle assembly
HK1222497A1 (en) Acoustic phase-plug
GB201321230D0 (en) Catalysts
GB201311130D0 (en) Greensleeves I
GB201310953D0 (en) New catalysts
GB201404608D0 (en) Nickel direct-plating
GB201316462D0 (en) Creating reports