EA200800758A1 - Ингибиторы фермента интегразы вич - Google Patents

Ингибиторы фермента интегразы вич

Info

Publication number
EA200800758A1
EA200800758A1 EA200800758A EA200800758A EA200800758A1 EA 200800758 A1 EA200800758 A1 EA 200800758A1 EA 200800758 A EA200800758 A EA 200800758A EA 200800758 A EA200800758 A EA 200800758A EA 200800758 A1 EA200800758 A1 EA 200800758A1
Authority
EA
Eurasian Patent Office
Prior art keywords
integrase inhibitors
inhibitors hiv
enzyme integrase
hiv
enzyme
Prior art date
Application number
EA200800758A
Other languages
English (en)
Inventor
Клаус Рупрехт Дресс
Тед Уилльям Джонсон
Майкл Бруно Плу
Стивен Пол Танис
Хойтун Чжу
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37684843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800758(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200800758A1 publication Critical patent/EA200800758A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I)и к их фармацевтически приемлемым солям и сольватам, к их синтезу и применению в качестве модуляторов или ингибиторов фермента интегразы вируса иммуннодефицита человека (ВИЧ).
EA200800758A 2005-10-07 2006-09-25 Ингибиторы фермента интегразы вич EA200800758A1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US72448405P 2005-10-07 2005-10-07
US73070105P 2005-10-26 2005-10-26
US76160506P 2006-01-24 2006-01-24
US82395406P 2006-08-30 2006-08-30
US82637906P 2006-09-20 2006-09-20
PCT/IB2006/002735 WO2007042883A1 (en) 2005-10-07 2006-09-25 Inhibitors of the hiv integrase enzyme

Publications (1)

Publication Number Publication Date
EA200800758A1 true EA200800758A1 (ru) 2008-08-29

Family

ID=37684843

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800758A EA200800758A1 (ru) 2005-10-07 2006-09-25 Ингибиторы фермента интегразы вич

Country Status (21)

Country Link
US (1) US20070099915A1 (ru)
EP (1) EP1934220A1 (ru)
JP (1) JP2009511463A (ru)
KR (1) KR20080042171A (ru)
AP (1) AP2008004400A0 (ru)
AR (1) AR061398A1 (ru)
AU (1) AU2006300926A1 (ru)
BR (1) BRPI0616657A2 (ru)
CA (1) CA2623506A1 (ru)
CR (1) CR9859A (ru)
EA (1) EA200800758A1 (ru)
IL (1) IL189939A0 (ru)
MA (1) MA29855B1 (ru)
NL (1) NL2000255A1 (ru)
NO (1) NO20081230L (ru)
PE (1) PE20070494A1 (ru)
RS (1) RS20080141A (ru)
SV (1) SV2009002864A (ru)
TW (1) TW200800219A (ru)
UY (1) UY29843A1 (ru)
WO (1) WO2007042883A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2563761C (en) * 2004-04-26 2009-12-29 Pfizer Inc. Inhibitors of the hiv integrase enzyme
AU2008350907A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN102532021B (zh) * 2012-01-31 2013-10-16 天津大学 2-烷氧基-3,4-二取代异喹啉-1(2h)-酮类衍生物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
EP0627436A1 (en) * 1991-08-08 1994-12-07 TSUMURA & CO. Carcinostatic compound and production thereof
EP0713877A1 (en) * 1993-07-19 1996-05-29 LUO, Xuande Qinghaosu derivatives against aids
US6057297A (en) * 1996-08-06 2000-05-02 Polifarma S.P.A. Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
US6403347B1 (en) * 1998-02-03 2002-06-11 Merck & Co., Inc. HIV integrase inhibitors
AU8009900A (en) * 1999-10-13 2001-04-23 Merck & Co., Inc. Hiv integrase inhibitors
CN1239472C (zh) * 2000-06-16 2006-02-01 布里斯托尔-迈尔斯斯奎布公司 Hiv整合酶抑制剂
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
CA2563761C (en) * 2004-04-26 2009-12-29 Pfizer Inc. Inhibitors of the hiv integrase enzyme
MX2007002731A (es) * 2004-09-07 2007-04-23 Pfizer Inhibidores de la enzima integrasa del hiv.

Also Published As

Publication number Publication date
SV2009002864A (es) 2009-02-19
PE20070494A1 (es) 2007-06-13
AP2008004400A0 (en) 2008-04-30
AU2006300926A1 (en) 2007-04-19
NO20081230L (no) 2008-04-08
AR061398A1 (es) 2008-08-27
MA29855B1 (fr) 2008-10-03
RS20080141A (en) 2009-07-15
CR9859A (es) 2008-06-20
EP1934220A1 (en) 2008-06-25
US20070099915A1 (en) 2007-05-03
UY29843A1 (es) 2007-05-31
KR20080042171A (ko) 2008-05-14
TW200800219A (en) 2008-01-01
IL189939A0 (en) 2008-08-07
BRPI0616657A2 (pt) 2011-06-28
NL2000255A1 (nl) 2007-04-11
JP2009511463A (ja) 2009-03-19
CA2623506A1 (en) 2007-04-19
WO2007042883A1 (en) 2007-04-19

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