MA33209B1 - Inhibiteurs de la replication du virus de l'hepatite c - Google Patents

Inhibiteurs de la replication du virus de l'hepatite c

Info

Publication number
MA33209B1
MA33209B1 MA34270A MA34270A MA33209B1 MA 33209 B1 MA33209 B1 MA 33209B1 MA 34270 A MA34270 A MA 34270A MA 34270 A MA34270 A MA 34270A MA 33209 B1 MA33209 B1 MA 33209B1
Authority
MA
Morocco
Prior art keywords
hepatitis
hcv
inhibitors
virus replication
compounds
Prior art date
Application number
MA34270A
Other languages
Arabic (ar)
English (en)
Inventor
Craig A Coburn
John A Mccauley
Steven W Ludmerer
Kun Liu
Joseph P Vacca
Hao Wu
Bin Hu
Richard Soll
Fei Sun
Xinghai Wang
Man Yan
Chengren Zhang
Mingwei Zheng
Bin Zhong
Jian Zhu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42781502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33209(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA33209B1 publication Critical patent/MA33209B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention concerne des composés de formule (I) utilisés comme inhibiteurs NS5A du virus de l'hépatite C (VHC), la synthèse de ces composés, et l'utilisation de ces composés pour inhiber l'activité NS5A du VHC, traiter ou prévenir les infections à VHC et inhiber la réplication du VHC et/ou la production du VHC dans un système cellulaire.
MA34270A 2009-03-27 2010-03-25 Inhibiteurs de la replication du virus de l'hepatite c MA33209B1 (fr)

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US24731809P 2009-09-30 2009-09-30
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KR20110130516A (ko) 2011-12-05
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JP5932929B2 (ja) 2016-06-08
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HK1160359A1 (zh) 2012-08-17
JP2012522000A (ja) 2012-09-20
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IL215094A0 (en) 2011-11-30
US9090661B2 (en) 2015-07-28
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