BR112012018529A2 - inibidores do vírus de hepatite c, sua composição farmacêutica e seu uso, e método para inibição da replicação de um vírus contendo rna - Google Patents
inibidores do vírus de hepatite c, sua composição farmacêutica e seu uso, e método para inibição da replicação de um vírus contendo rnaInfo
- Publication number
- BR112012018529A2 BR112012018529A2 BR112012018529A BR112012018529A BR112012018529A2 BR 112012018529 A2 BR112012018529 A2 BR 112012018529A2 BR 112012018529 A BR112012018529 A BR 112012018529A BR 112012018529 A BR112012018529 A BR 112012018529A BR 112012018529 A2 BR112012018529 A2 BR 112012018529A2
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- hepatitis
- pharmaceutical composition
- compounds
- rna
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000006454 hepatitis Diseases 0.000 abstract 2
- 231100000283 hepatitis Toxicity 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
inibidores do vírus de hepatite c. a presente invenção refere-se a compostos da fórmula (i), e sais farmaceuticamente aceitáveis, ésteres, ou pró-fármacos dos mesmos: q-g-a-l-b-w (i) que inibem vírus contendo rna, particularmente vírus de hepatite c (hcv). consequentemente, os compostos da presente invenção interferem refere-se ainda a composições farmacêuticas compreendendo os compostos acima mencionados para administração a um indivíduo sofrendo de infecção. por hcv. a invenção também se refere a métodos de tratamento de uma infecção por hcv em um indivíduo por administração de uma composição farmacêutica compreendendo os compostos da presente invenção.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29791810P | 2010-01-25 | 2010-01-25 | |
US31430410P | 2010-03-16 | 2010-03-16 | |
PCT/US2011/022401 WO2011091417A1 (en) | 2010-01-25 | 2011-01-25 | Hepatitis c virus inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012018529A2 true BR112012018529A2 (pt) | 2016-08-09 |
Family
ID=44307283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012018529A BR112012018529A2 (pt) | 2010-01-25 | 2011-01-25 | inibidores do vírus de hepatite c, sua composição farmacêutica e seu uso, e método para inibição da replicação de um vírus contendo rna |
Country Status (22)
Country | Link |
---|---|
US (1) | US8785487B2 (pt) |
EP (1) | EP2528436A4 (pt) |
JP (1) | JP2013518060A (pt) |
KR (1) | KR20120107529A (pt) |
CN (1) | CN102843909A (pt) |
AU (1) | AU2011207492A1 (pt) |
BR (1) | BR112012018529A2 (pt) |
CA (1) | CA2787309A1 (pt) |
CL (1) | CL2012002057A1 (pt) |
CO (1) | CO6571891A2 (pt) |
CR (1) | CR20120397A (pt) |
CU (1) | CU20120110A7 (pt) |
EA (1) | EA201201031A1 (pt) |
EC (1) | ECSP12012067A (pt) |
GT (1) | GT201200230A (pt) |
IL (1) | IL221033A0 (pt) |
MA (1) | MA34013B1 (pt) |
MX (1) | MX2012008658A (pt) |
PE (1) | PE20130244A1 (pt) |
SG (1) | SG188957A1 (pt) |
TN (1) | TN2012000358A1 (pt) |
WO (1) | WO2011091417A1 (pt) |
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-
2011
- 2011-01-25 JP JP2012550208A patent/JP2013518060A/ja not_active Withdrawn
- 2011-01-25 CA CA2787309A patent/CA2787309A1/en not_active Abandoned
- 2011-01-25 KR KR1020127022155A patent/KR20120107529A/ko not_active Application Discontinuation
- 2011-01-25 SG SG2013016357A patent/SG188957A1/en unknown
- 2011-01-25 BR BR112012018529A patent/BR112012018529A2/pt not_active IP Right Cessation
- 2011-01-25 MX MX2012008658A patent/MX2012008658A/es not_active Application Discontinuation
- 2011-01-25 WO PCT/US2011/022401 patent/WO2011091417A1/en active Application Filing
- 2011-01-25 US US13/013,212 patent/US8785487B2/en active Active
- 2011-01-25 CN CN2011800153764A patent/CN102843909A/zh active Pending
- 2011-01-25 EP EP11735350.8A patent/EP2528436A4/en not_active Withdrawn
- 2011-01-25 PE PE2012001072A patent/PE20130244A1/es not_active Application Discontinuation
- 2011-01-25 EA EA201201031A patent/EA201201031A1/ru unknown
- 2011-01-25 MA MA35161A patent/MA34013B1/fr unknown
- 2011-01-25 AU AU2011207492A patent/AU2011207492A1/en not_active Abandoned
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2012
- 2012-07-16 TN TNP2012000358A patent/TN2012000358A1/en unknown
- 2012-07-19 IL IL221033A patent/IL221033A0/en unknown
- 2012-07-24 CL CL2012002057A patent/CL2012002057A1/es unknown
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- 2012-07-25 CO CO12125014A patent/CO6571891A2/es not_active Application Discontinuation
- 2012-07-25 EC ECSP12012067 patent/ECSP12012067A/es unknown
- 2012-07-25 GT GT201200230A patent/GT201200230A/es unknown
- 2012-07-26 CR CR20120397A patent/CR20120397A/es unknown
Also Published As
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CO6571891A2 (es) | 2012-11-30 |
MA34013B1 (fr) | 2013-02-01 |
AU2011207492A1 (en) | 2012-08-16 |
KR20120107529A (ko) | 2012-10-02 |
ECSP12012067A (es) | 2012-12-28 |
EA201201031A1 (ru) | 2013-02-28 |
EP2528436A1 (en) | 2012-12-05 |
EP2528436A4 (en) | 2013-07-10 |
US8785487B2 (en) | 2014-07-22 |
GT201200230A (es) | 2015-06-02 |
IL221033A0 (en) | 2012-09-24 |
PE20130244A1 (es) | 2013-03-10 |
CL2012002057A1 (es) | 2013-05-10 |
CA2787309A1 (en) | 2011-07-28 |
US20110189129A1 (en) | 2011-08-04 |
MX2012008658A (es) | 2012-12-05 |
JP2013518060A (ja) | 2013-05-20 |
CN102843909A (zh) | 2012-12-26 |
CU20120110A7 (es) | 2012-12-17 |
WO2011091417A1 (en) | 2011-07-28 |
TN2012000358A1 (en) | 2014-01-30 |
SG188957A1 (en) | 2013-05-31 |
CR20120397A (es) | 2013-05-15 |
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