BR112018067964A2 - agentes antivirais para hepatite b - Google Patents
agentes antivirais para hepatite bInfo
- Publication number
- BR112018067964A2 BR112018067964A2 BR112018067964A BR112018067964A BR112018067964A2 BR 112018067964 A2 BR112018067964 A2 BR 112018067964A2 BR 112018067964 A BR112018067964 A BR 112018067964A BR 112018067964 A BR112018067964 A BR 112018067964A BR 112018067964 A2 BR112018067964 A2 BR 112018067964A2
- Authority
- BR
- Brazil
- Prior art keywords
- hepatitis
- hbv
- present
- antiviral agents
- compounds
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000700721 Hepatitis B virus Species 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/18—Sulfonamides
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- C07C2603/74—Adamantanes
Abstract
Applications Claiming Priority (5)
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US201662304671P | 2016-03-07 | 2016-03-07 | |
US62/304,671 | 2016-03-07 | ||
US201662337675P | 2016-05-17 | 2016-05-17 | |
US62/337,675 | 2016-05-17 | ||
PCT/US2017/020853 WO2017155844A1 (en) | 2016-03-07 | 2017-03-06 | Hepatitis b antiviral agents |
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BR112018067964A2 true BR112018067964A2 (pt) | 2019-01-15 |
BR112018067964B1 BR112018067964B1 (pt) | 2024-01-16 |
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BR112018067964-0A BR112018067964B1 (pt) | 2016-03-07 | 2017-03-06 | Composto, composição farmacêutica que o compreende e uso do referido composto |
Country Status (18)
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US (4) | US10179792B2 (pt) |
EP (1) | EP3426245B1 (pt) |
JP (1) | JP6904970B2 (pt) |
KR (1) | KR102398439B1 (pt) |
CN (1) | CN109069488B (pt) |
AU (1) | AU2017229007B2 (pt) |
BR (1) | BR112018067964B1 (pt) |
CA (1) | CA3017020C (pt) |
CL (1) | CL2018002528A1 (pt) |
CO (1) | CO2018010748A2 (pt) |
ES (1) | ES2938341T3 (pt) |
IL (1) | IL261599B (pt) |
MX (1) | MX2018010805A (pt) |
PH (1) | PH12018550148A1 (pt) |
PL (1) | PL3426245T3 (pt) |
SG (1) | SG11201807543YA (pt) |
WO (1) | WO2017155844A1 (pt) |
ZA (1) | ZA201806561B (pt) |
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