UY38439A - Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) - Google Patents

Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)

Info

Publication number
UY38439A
UY38439A UY0001038439A UY38439A UY38439A UY 38439 A UY38439 A UY 38439A UY 0001038439 A UY0001038439 A UY 0001038439A UY 38439 A UY38439 A UY 38439A UY 38439 A UY38439 A UY 38439A
Authority
UY
Uruguay
Prior art keywords
hbv
virus
hepatitis
pyridines
pyrazole
Prior art date
Application number
UY0001038439A
Other languages
English (en)
Inventor
Susanne Bonsmann
Alastair Donald
Andreas Urban
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of UY38439A publication Critical patent/UY38439A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos e intermedios para fabricar los compuestos.
UY0001038439A 2018-11-02 2019-10-31 Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) UY38439A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000874 2018-11-02

Publications (1)

Publication Number Publication Date
UY38439A true UY38439A (es) 2020-05-29

Family

ID=64362284

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038439A UY38439A (es) 2018-11-02 2019-10-31 Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)

Country Status (14)

Country Link
US (1) US20220009922A1 (es)
EP (1) EP3873899A1 (es)
JP (1) JP2022512873A (es)
KR (1) KR20210098984A (es)
CN (1) CN112969702A (es)
AR (1) AR116946A1 (es)
AU (1) AU2019373677B2 (es)
CA (1) CA3118379A1 (es)
EA (1) EA202191220A1 (es)
IL (1) IL282687A (es)
SG (1) SG11202104080UA (es)
TW (1) TW202031655A (es)
UY (1) UY38439A (es)
WO (1) WO2020089452A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR117188A1 (es) * 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19817264A1 (de) 1998-04-18 1999-10-21 Bayer Ag Neue Dihydropyrimidine
WO2000058302A1 (de) 1999-03-25 2000-10-05 Bayer Aktiengesellschaft Dihydropyrimidine und ihre verwendung zur behandlung von hepatitis b
DE60033657T2 (de) 1999-04-23 2007-11-08 Extenday IP Ltd., Kumeu Foliebefestigungs- und verankerungsteil
AU3009801A (en) 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
AU2003244632A1 (en) 2002-07-25 2004-02-25 Pharmacia Italia S.P.A. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2006033995A2 (en) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
EP2726459B1 (en) 2011-07-01 2019-09-11 Baruch S. Blumberg Institute Sulfamoylbenzamide derivatives as antiviral agents against hbv infection
ES2649410T3 (es) 2011-12-21 2018-01-11 Novira Therapeutics Inc. Agentes antivirales para la hepatitis B
JP6162144B2 (ja) 2012-01-06 2017-07-19 ヤンセン・サイエンシズ・アイルランド・ユーシー ４，４−二置換−１，４−ジヒドロピリミジン、及びｂ型肝炎の処置のための医薬としてのその使用
TW201920090A (zh) 2012-08-28 2019-06-01 愛爾蘭商健生科學愛爾蘭無限公司 胺磺醯基－芳醯胺類及其做為治療ｂ型肝炎之醫藥劑的用途
BR112015004161B8 (pt) 2012-08-28 2022-11-08 Janssen Sciences Ireland Uc Derivado bicíclico fusionado de sulfamoíla e seu uso no tratamento e prevenção de infecção por vírus da hepatite b, bem como composição farmacêutica e produto que o compreende
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
RS57999B1 (sr) 2013-05-17 2019-01-31 Janssen Sciences Ireland Uc Derivati sulfamoiltiofenamida i njihova primena kao lekovi za tretman hepatitisa b
EA201592126A1 (ru) 2013-05-17 2016-05-31 Ф. Хоффманн-Ля Рош Аг 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
AU2014294997B2 (en) 2013-07-25 2018-03-22 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
CA2927560A1 (en) 2013-10-18 2015-04-23 Indiana University Research And Technology Corporation Hepatitis b viral assembly effectors
KR20160127714A (ko) 2013-11-14 2016-11-04 노비라 테라퓨틱스, 인코포레이티드 아제판 유도체 및 b형 간염 감염의 치료 방법
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
WO2015133428A1 (ja) 2014-03-06 2015-09-11 株式会社テイエルブイ 蒸気システム
LT3114128T (lt) 2014-03-07 2019-03-25 F. Hoffmann-La Roche Ag Nauji 6 padėtyje kondensuoti heteroarildihidropirimidinai, skirti hepatito b virusinės infekcijos gydymui ir profilaktikai
HUE046567T2 (hu) 2014-03-13 2020-03-30 Univ Indiana Res & Tech Corp Hepatitis B mag protein allosztérikus modulátorok
EP3122747B1 (en) 2014-03-28 2020-05-20 North & South Brother Pharmacy Investment Company Limited Dihydropyrimidine compounds and their application in pharmaceuticals
US20170266197A1 (en) 2014-05-09 2017-09-21 Indiana University Research And Technology Corporation Methods and compositions for treating hepatitis b virus infections
BR112017002970B1 (pt) 2014-08-14 2023-04-11 F. Hoffmann-La Roche Ag Novas piridazonas e triazinonas para o tratamento e profilaxia da infecção pelo vírus da hepatite b
JP2018504373A (ja) 2014-12-02 2018-02-15 ノヴィラ・セラピューティクス・インコーポレイテッド Ｈｂｖ治療用のスルフィドアルキル及びピリジルリバーススルホンアミド化合物
CA2972434A1 (en) 2014-12-30 2016-07-07 Novira Therapeutics, Inc. Derivatives and methods of treating hepatitis b infections
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
CN107427514B (zh) 2015-03-16 2021-07-13 豪夫迈·罗氏有限公司 使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
WO2016161268A1 (en) 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
JP6462155B2 (ja) 2015-05-04 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療用のＨＢｓＡｇ（ＨＢＶ表面抗原）及びＨＢＶ ＤＮＡ産生の阻害剤としてのテトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2017013046A1 (en) 2015-07-21 2017-01-26 F. Hoffmann-La Roche Ag Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2017015451A1 (en) 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TWI721016B (zh) 2015-09-15 2021-03-11 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
JP6845231B2 (ja) 2015-09-29 2021-03-17 ノヴィラ・セラピューティクス・インコーポレイテッド Ｂ型肝炎抗ウイルス薬の結晶形態
US10787462B2 (en) * 2015-10-23 2020-09-29 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP3372606B1 (en) 2015-11-04 2020-04-08 Qilu Pharmaceutical Co., Ltd Crystal form, preparation method and intermediate of dihydropyrido ring compound
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
EP3458455B1 (en) 2016-05-20 2021-06-16 F. Hoffmann-La Roche AG Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases
TW201806956A (zh) * 2016-06-29 2018-03-01 諾維拉治療公司 二氮呯酮衍生物及治療ｂ型肝炎感染之方法
AU2017290755B2 (en) * 2016-06-29 2021-07-01 Novira Therapeutics, Inc. Diazepinone derivatives and their use in the treatment of hepatitis B infections
WO2018011160A1 (en) 2016-07-14 2018-01-18 F. Hoffmann-La Roche Ag 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
JP7051804B2 (ja) 2016-07-14 2022-04-11 エフ．ホフマン－ラ ロシュ アーゲー 感染症の治療のための６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物と６，７－ジヒドロ－４Ｈ－トリアゾロ［１，５－ａ］ピラジン化合物
WO2018011162A1 (en) 2016-07-14 2018-01-18 F. Hoffmann-La Roche Ag Carboxy 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CA3036245C (en) 2016-09-13 2021-07-20 Arbutus Biopharma Corporation Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
BR112019018230A2 (pt) 2017-03-02 2020-07-21 Assembly Biosciences, Inc. compostos de sulfamida cíclica e métodos de sua utilização
MA49014A (fr) 2017-03-21 2020-02-05 Arbutus Biopharma Corp Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant

Also Published As

Publication number Publication date
CA3118379A1 (en) 2020-05-07
AU2019373677B2 (en) 2022-03-31
US20220009922A1 (en) 2022-01-13
EA202191220A1 (ru) 2021-07-29
SG11202104080UA (en) 2021-05-28
CN112969702A (zh) 2021-06-15
JP2022512873A (ja) 2022-02-07
WO2020089452A1 (en) 2020-05-07
TW202031655A (zh) 2020-09-01
AU2019373677A1 (en) 2021-05-27
IL282687A (en) 2021-06-30
KR20210098984A (ko) 2021-08-11
EP3873899A1 (en) 2021-09-08
AR116946A1 (es) 2021-06-30

Similar Documents

Publication Publication Date Title
ECSP20029569A (es) Nuevas indol-2-carboxamidas sustituidas con pirazolo piperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb)
ECSP20029558A (es) Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb)
ECSP21031082A (es) Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
CO2019000069A2 (es) Agentes antivirales contra la hepatitis b
UY38434A (es) Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv)
UY38436A (es) Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
CL2020000487A1 (es) Agentes antivirales contra la hepatitis b.
ECSP21078893A (es) Nuevas fenil y piridil ureas activas contra el virus de la hepatitis b (vhb)
UY38435A (es) Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb)
UY38439A (es) Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
ECSP21079317A (es) Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
ECSP21080338A (es) Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb)
UY38681A (es) Nuevas indolizina-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
PH12021550978A1 (en) Novel urea 6,7-dihydro-4h-thiazolo[5,4-c]pyridines active against the hepatitis b virus (hbv)
EA202192969A1 (ru) Новые оксалилпиперазины, активные против вируса гепатита b (вгв)
EA202192967A1 (ru) Новые индол-2-карбоксамиды, активные против вируса гепатита b (вгв)
BR112022011212A2 (pt) Derivados de heteroarildi-hidropirimidina e métodos de tratamento de infecções de hepatite b
EA202192968A1 (ru) Новые фенил- и пиридилмочевины, активные против вируса гепатита b (вгв)