ECSP21079317A - Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Info

Publication number
ECSP21079317A
ECSP21079317A ECSENADI202179317A ECDI202179317A ECSP21079317A EC SP21079317 A ECSP21079317 A EC SP21079317A EC SENADI202179317 A ECSENADI202179317 A EC SENADI202179317A EC DI202179317 A ECDI202179317 A EC DI202179317A EC SP21079317 A ECSP21079317 A EC SP21079317A
Authority
EC
Ecuador
Prior art keywords
hbv
virus
active against
against hepatitis
compounds
Prior art date
Application number
ECSENADI202179317A
Other languages
English (en)
Inventor
Jasper Springer
Burkhard Klenke
Alastair Donald
Andreas Urban
Susanne Bonsmann
Original Assignee
Aicuris Gmbh Co Kg [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh Co Kg [De/De] filed Critical Aicuris Gmbh Co Kg [De/De]
Publication of ECSP21079317A publication Critical patent/ECSP21079317A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
ECSENADI202179317A 2019-04-30 2021-10-26 Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) ECSP21079317A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19172005 2019-04-30
EP19172398 2019-05-02

Publications (1)

Publication Number Publication Date
ECSP21079317A true ECSP21079317A (es) 2021-11-30

Family

ID=70391142

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202179317A ECSP21079317A (es) 2019-04-30 2021-10-26 Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)

Country Status (17)

Country Link
US (1) US20220306647A1 (es)
EP (1) EP3962914A1 (es)
JP (1) JP2022530522A (es)
KR (1) KR20220004131A (es)
CN (1) CN113767101A (es)
AU (1) AU2020267015A1 (es)
BR (1) BR112021021564A2 (es)
CA (1) CA3138643A1 (es)
CL (1) CL2021002799A1 (es)
CU (1) CU20210088A7 (es)
EC (1) ECSP21079317A (es)
IL (1) IL287278A (es)
MX (1) MX2021013085A (es)
SG (1) SG11202111236UA (es)
TW (1) TWI770501B (es)
UY (1) UY38682A (es)
WO (1) WO2020221826A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023005983A (es) 2020-11-23 2023-08-15 Enanta Pharm Inc Nuevos agentes antivirales derivados de la espiropirrolidina.

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Also Published As

Publication number Publication date
CA3138643A1 (en) 2020-11-05
WO2020221826A1 (en) 2020-11-05
MX2021013085A (es) 2021-11-17
TWI770501B (zh) 2022-07-11
CN113767101A (zh) 2021-12-07
TW202106687A (zh) 2021-02-16
EP3962914A1 (en) 2022-03-09
UY38682A (es) 2020-11-30
JP2022530522A (ja) 2022-06-29
SG11202111236UA (en) 2021-11-29
AU2020267015A1 (en) 2021-12-23
CL2021002799A1 (es) 2022-06-10
BR112021021564A2 (pt) 2022-01-04
IL287278A (en) 2021-12-01
KR20220004131A (ko) 2022-01-11
US20220306647A1 (en) 2022-09-29
CU20210088A7 (es) 2022-06-06

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