MX2021013085A - Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb). - Google Patents
Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb).Info
- Publication number
- MX2021013085A MX2021013085A MX2021013085A MX2021013085A MX2021013085A MX 2021013085 A MX2021013085 A MX 2021013085A MX 2021013085 A MX2021013085 A MX 2021013085A MX 2021013085 A MX2021013085 A MX 2021013085A MX 2021013085 A MX2021013085 A MX 2021013085A
- Authority
- MX
- Mexico
- Prior art keywords
- hbv
- hepatitis
- virus
- active against
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19172005 | 2019-04-30 | ||
EP19172398 | 2019-05-02 | ||
PCT/EP2020/061948 WO2020221826A1 (en) | 2019-04-30 | 2020-04-29 | Novel indole-2-carboxamides active against the hepatitis b virus (hbv) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021013085A true MX2021013085A (es) | 2021-11-17 |
Family
ID=70391142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013085A MX2021013085A (es) | 2019-04-30 | 2020-04-29 | Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb). |
Country Status (17)
Country | Link |
---|---|
US (1) | US20220306647A1 (es) |
EP (1) | EP3962914A1 (es) |
JP (1) | JP2022530522A (es) |
KR (1) | KR20220004131A (es) |
CN (1) | CN113767101A (es) |
AU (1) | AU2020267015A1 (es) |
BR (1) | BR112021021564A2 (es) |
CA (1) | CA3138643A1 (es) |
CL (1) | CL2021002799A1 (es) |
CU (1) | CU20210088A7 (es) |
EC (1) | ECSP21079317A (es) |
IL (1) | IL287278A (es) |
MX (1) | MX2021013085A (es) |
SG (1) | SG11202111236UA (es) |
TW (1) | TWI770501B (es) |
UY (1) | UY38682A (es) |
WO (1) | WO2020221826A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2023005983A (es) | 2020-11-23 | 2023-08-15 | Enanta Pharm Inc | Nuevos agentes antivirales derivados de la espiropirrolidina. |
US12006291B2 (en) | 2022-01-11 | 2024-06-11 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid |
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DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
EP1189501B1 (en) | 1999-04-23 | 2007-02-28 | Extenday IP Limited | Sheet fastening and anchoring component |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
US7476666B2 (en) | 2004-06-09 | 2009-01-13 | Merck & Co., Inc. | HIV integrase inhibitors |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
CN103889953B (zh) | 2011-07-01 | 2016-06-08 | 巴鲁﹒S﹒布隆伯格研究所 | 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 |
SG10201608528YA (en) | 2011-12-21 | 2016-12-29 | Novira Therapeutics Inc | Hepatitis b antiviral agents |
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SG11201501360TA (en) | 2012-08-28 | 2015-03-30 | Janssen Sciences Ireland Uc | Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis b |
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CA2935719C (en) | 2013-07-25 | 2021-11-02 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
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-
2020
- 2020-04-29 MX MX2021013085A patent/MX2021013085A/es unknown
- 2020-04-29 KR KR1020217038545A patent/KR20220004131A/ko unknown
- 2020-04-29 EP EP20720857.0A patent/EP3962914A1/en not_active Withdrawn
- 2020-04-29 CN CN202080032420.1A patent/CN113767101A/zh active Pending
- 2020-04-29 AU AU2020267015A patent/AU2020267015A1/en not_active Abandoned
- 2020-04-29 CU CU2021000088A patent/CU20210088A7/es unknown
- 2020-04-29 JP JP2021564278A patent/JP2022530522A/ja active Pending
- 2020-04-29 US US17/607,605 patent/US20220306647A1/en active Pending
- 2020-04-29 CA CA3138643A patent/CA3138643A1/en active Pending
- 2020-04-29 BR BR112021021564A patent/BR112021021564A2/pt not_active IP Right Cessation
- 2020-04-29 WO PCT/EP2020/061948 patent/WO2020221826A1/en unknown
- 2020-04-29 SG SG11202111236UA patent/SG11202111236UA/en unknown
- 2020-04-30 TW TW109114654A patent/TWI770501B/zh active
- 2020-05-04 UY UY0001038682A patent/UY38682A/es unknown
-
2021
- 2021-10-14 IL IL287278A patent/IL287278A/en unknown
- 2021-10-25 CL CL2021002799A patent/CL2021002799A1/es unknown
- 2021-10-26 EC ECSENADI202179317A patent/ECSP21079317A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112021021564A2 (pt) | 2022-01-04 |
AU2020267015A1 (en) | 2021-12-23 |
UY38682A (es) | 2020-11-30 |
JP2022530522A (ja) | 2022-06-29 |
ECSP21079317A (es) | 2021-11-30 |
KR20220004131A (ko) | 2022-01-11 |
CU20210088A7 (es) | 2022-06-06 |
EP3962914A1 (en) | 2022-03-09 |
SG11202111236UA (en) | 2021-11-29 |
CA3138643A1 (en) | 2020-11-05 |
CN113767101A (zh) | 2021-12-07 |
TWI770501B (zh) | 2022-07-11 |
CL2021002799A1 (es) | 2022-06-10 |
TW202106687A (zh) | 2021-02-16 |
WO2020221826A1 (en) | 2020-11-05 |
US20220306647A1 (en) | 2022-09-29 |
IL287278A (en) | 2021-12-01 |
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