MX2021013105A - Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb). - Google Patents
Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb).Info
- Publication number
- MX2021013105A MX2021013105A MX2021013105A MX2021013105A MX2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A
- Authority
- MX
- Mexico
- Prior art keywords
- hbv
- hepatitis
- virus
- novel
- piperazines
- Prior art date
Links
- 241000700721 Hepatitis B virus Species 0.000 title abstract 5
- -1 oxalyl piperazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19172008 | 2019-04-30 | ||
EP19172402 | 2019-05-02 | ||
PCT/EP2020/061920 WO2020221811A1 (en) | 2019-04-30 | 2020-04-29 | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021013105A true MX2021013105A (es) | 2021-11-17 |
Family
ID=70456795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013105A MX2021013105A (es) | 2019-04-30 | 2020-04-29 | Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb). |
Country Status (17)
Country | Link |
---|---|
US (1) | US20220227737A1 (es) |
EP (1) | EP3962909B1 (es) |
JP (1) | JP2022533008A (es) |
KR (1) | KR20220003023A (es) |
CN (1) | CN113748111A (es) |
AU (1) | AU2020266258A1 (es) |
BR (1) | BR112021021652A2 (es) |
CA (1) | CA3138380A1 (es) |
CL (1) | CL2021002798A1 (es) |
CU (1) | CU20210090A7 (es) |
EC (1) | ECSP21080338A (es) |
IL (1) | IL287269A (es) |
MX (1) | MX2021013105A (es) |
SG (1) | SG11202111493WA (es) |
TW (1) | TWI753418B (es) |
UY (1) | UY38684A (es) |
WO (1) | WO2020221811A1 (es) |
Family Cites Families (53)
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DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
EP1189501B1 (en) | 1999-04-23 | 2007-02-28 | Extenday IP Limited | Sheet fastening and anchoring component |
AU3009801A (en) | 1999-12-22 | 2001-07-03 | Bayer Aktiengesellschaft | Combinations of medicaments for treating viral diseases |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
PE20131210A1 (es) * | 2007-12-19 | 2013-10-31 | Genentech Inc | Derivados de 5-anilinoimidazopiridina como inhibidores de mek |
CN103889953B (zh) | 2011-07-01 | 2016-06-08 | 巴鲁﹒S﹒布隆伯格研究所 | 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 |
SG10201608528YA (en) | 2011-12-21 | 2016-12-29 | Novira Therapeutics Inc | Hepatitis b antiviral agents |
US9233933B2 (en) | 2012-01-06 | 2016-01-12 | Janssen Sciences Ireland Uc | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis B |
CR20200276A (es) | 2012-08-28 | 2021-01-27 | Janssen Sciences Ireland Uc | Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059) |
SG11201501360TA (en) | 2012-08-28 | 2015-03-30 | Janssen Sciences Ireland Uc | Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
CN105960400B (zh) | 2013-05-17 | 2019-05-31 | 爱尔兰詹森科学公司 | 氨磺酰基噻吩酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
BR112015028873A2 (pt) | 2013-05-17 | 2017-07-25 | Hoffmann La Roche | heteroaril-diidro-pirimidinas interligados na posição 6, para o tratamento e profilaxia de infecção pelo vírus da hepatite b |
CA2935719C (en) | 2013-07-25 | 2021-11-02 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
CN105828823B (zh) | 2013-10-18 | 2019-06-14 | 美国印第安纳大学研究和技术公司 | 乙型肝炎病毒组装效应物 |
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US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
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PL3116316T3 (pl) | 2014-03-13 | 2020-03-31 | Indiana University Research And Technology Corporation | Allosteryczne modulatory białka rdzeniowego wirusa zapalenia wątroby typu B |
KR20160133563A (ko) | 2014-03-28 | 2016-11-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 화합물 및 이의 약제학적 용도 |
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JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
CA3036245C (en) | 2016-09-13 | 2021-07-20 | Arbutus Biopharma Corporation | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same |
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-
2020
- 2020-04-29 BR BR112021021652A patent/BR112021021652A2/pt unknown
- 2020-04-29 EP EP20721247.3A patent/EP3962909B1/en active Active
- 2020-04-29 CU CU2021000090A patent/CU20210090A7/es unknown
- 2020-04-29 AU AU2020266258A patent/AU2020266258A1/en not_active Abandoned
- 2020-04-29 US US17/607,430 patent/US20220227737A1/en active Pending
- 2020-04-29 MX MX2021013105A patent/MX2021013105A/es unknown
- 2020-04-29 CN CN202080032036.1A patent/CN113748111A/zh active Pending
- 2020-04-29 SG SG11202111493WA patent/SG11202111493WA/en unknown
- 2020-04-29 KR KR1020217038550A patent/KR20220003023A/ko unknown
- 2020-04-29 CA CA3138380A patent/CA3138380A1/en active Pending
- 2020-04-29 WO PCT/EP2020/061920 patent/WO2020221811A1/en unknown
- 2020-04-29 JP JP2021564290A patent/JP2022533008A/ja active Pending
- 2020-04-30 TW TW109114651A patent/TWI753418B/zh active
- 2020-05-04 UY UY0001038684A patent/UY38684A/es unknown
-
2021
- 2021-10-14 IL IL287269A patent/IL287269A/en unknown
- 2021-10-25 CL CL2021002798A patent/CL2021002798A1/es unknown
- 2021-11-12 EC ECSENADI202180338A patent/ECSP21080338A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020266258A2 (en) | 2022-05-05 |
AU2020266258A1 (en) | 2021-12-23 |
EP3962909B1 (en) | 2023-10-04 |
JP2022533008A (ja) | 2022-07-21 |
SG11202111493WA (en) | 2021-11-29 |
ECSP21080338A (es) | 2021-12-30 |
UY38684A (es) | 2020-11-30 |
CL2021002798A1 (es) | 2022-06-10 |
WO2020221811A1 (en) | 2020-11-05 |
CN113748111A (zh) | 2021-12-03 |
EP3962909A1 (en) | 2022-03-09 |
CA3138380A1 (en) | 2020-11-05 |
TWI753418B (zh) | 2022-01-21 |
CU20210090A7 (es) | 2022-06-06 |
IL287269A (en) | 2021-12-01 |
KR20220003023A (ko) | 2022-01-07 |
BR112021021652A2 (pt) | 2021-12-21 |
US20220227737A1 (en) | 2022-07-21 |
TW202106678A (zh) | 2021-02-16 |
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