CL2021002798A1 - Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb)

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Publication number
CL2021002798A1
CL2021002798A1 CL2021002798A CL2021002798A CL2021002798A1 CL 2021002798 A1 CL2021002798 A1 CL 2021002798A1 CL 2021002798 A CL2021002798 A CL 2021002798A CL 2021002798 A CL2021002798 A CL 2021002798A CL 2021002798 A1 CL2021002798 A1 CL 2021002798A1
Authority
CL
Chile
Prior art keywords
hbv
virus
hepatitis
new
piperazines
Prior art date
Application number
CL2021002798A
Other languages
English (en)
Inventor
Alastair Donald
Andreas Urban
Susanne Bonsmann
Thomas Goldner
Brondo Miquel Àngel Pericàs
Esther Alza Barrios
Elena Detta
Justine Raymond
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of CL2021002798A1 publication Critical patent/CL2021002798A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
CL2021002798A 2019-04-30 2021-10-25 Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb) CL2021002798A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19172008 2019-04-30
EP19172402 2019-05-02

Publications (1)

Publication Number Publication Date
CL2021002798A1 true CL2021002798A1 (es) 2022-06-10

Family

ID=70456795

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021002798A CL2021002798A1 (es) 2019-04-30 2021-10-25 Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb)

Country Status (17)

Country Link
US (1) US20220227737A1 (es)
EP (1) EP3962909B1 (es)
JP (1) JP2022533008A (es)
KR (1) KR20220003023A (es)
CN (1) CN113748111A (es)
AU (1) AU2020266258A1 (es)
BR (1) BR112021021652A2 (es)
CA (1) CA3138380A1 (es)
CL (1) CL2021002798A1 (es)
CU (1) CU20210090A7 (es)
EC (1) ECSP21080338A (es)
IL (1) IL287269A (es)
MX (1) MX2021013105A (es)
SG (1) SG11202111493WA (es)
TW (1) TWI753418B (es)
UY (1) UY38684A (es)
WO (1) WO2020221811A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116396204B (zh) * 2023-03-29 2024-09-24 无锡科华生物科技有限公司 一种4,6,7-三氟-1h-吲哚-2-羧酸的制备方法

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Also Published As

Publication number Publication date
JP2022533008A (ja) 2022-07-21
AU2020266258A2 (en) 2022-05-05
ECSP21080338A (es) 2021-12-30
CN113748111A (zh) 2021-12-03
SG11202111493WA (en) 2021-11-29
US20220227737A1 (en) 2022-07-21
EP3962909A1 (en) 2022-03-09
CA3138380A1 (en) 2020-11-05
TWI753418B (zh) 2022-01-21
EP3962909B1 (en) 2023-10-04
BR112021021652A2 (pt) 2021-12-21
UY38684A (es) 2020-11-30
WO2020221811A1 (en) 2020-11-05
TW202106678A (zh) 2021-02-16
KR20220003023A (ko) 2022-01-07
AU2020266258A1 (en) 2021-12-23
CU20210090A7 (es) 2022-06-06
IL287269A (en) 2021-12-01
MX2021013105A (es) 2021-11-17

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